Mohmmad Younus Wani - Böcker

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant

Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Chalcone is a highly versatile scaffold with a broad range of applications. Serving as a precursor for various organic molecules and natural flavonoids, it exhibits significant biological activities and unique physical properties, including semiconductor behavior, non-linear optical effects, fluorescence, and electronic characteristics. Chalcones have attracted considerable research interest due to their pharmacological potential and the ease with which their biological activity and other properties can be modified through subtle structural changes along the ?,?-unsaturated backbone. Beyond their medicinal value, chalcones are utilized in the food and cosmetic industries as additives, owing to their UV-protective qualities. Additionally, they serve as chemosensors and probes in analytical applications. The book Chalcones and Their Derivatives: From Synthesis to Applications explores this remarkable molecule, detailing various synthetic methods, its biological significance, and its diverse applications across multiple fields. Serving as both a comprehensive reference for researchers and an essential guide for postgraduate students, this work provides valuable insights into the development and utilization of chalcone-based molecules for a wide array of purposes.

Addresses the lack of in-depth exploration in recent publications, offering a consolidated and holistic perspective on the scaffold's immense potential in various scientific domainsHighlighting the chalcone scaffold's versatility, showcasing its role as a precursor for diverse organic molecules and its contribution to the synthesis of natural flavonoidsUnderlines the practical significance of chalcones in industries like food and cosmetics, thanks to their UV protection properties

This book provides an overview of antimicrobial resistance (AMR), including its underlying causes, mechanisms, global ramifications, and the potential of probiotics as a viable approach in combating AMR. It explores the potential of probiotics to counteract resistance by competing with pathogenic bacteria, modulating the immune system, and producing antimicrobial compounds. It also examines the applications of probiotics in biofilm-related infections, respiratory health, urinary tract infections, and oral health. Additionally, the book covers important considerations such as safety, regulatory frameworks, challenges, and risks associated with probiotics in AMR. It provides insights into the development of novel approaches, including engineering probiotics for enhanced antimicrobial activity and exploring synergistic approaches by combining probiotics with traditional antibiotics. Toward the end, the book explores future directions and potential applications of probiotics, including their role in neonatal care and personalized probiotic interventions. This book is primarily intended for healthcare professionals, researchers, and individuals working in the fields of microbiology, infectious diseases, and public health.Key features1) Discusses the mechanisms, impacts, and global concerns associated with antimicrobial resistance2) Highlights the various methods utilized by probiotics to effectively counter resistant pathogens3) Explores the potential of probiotics in enhancing human health and combating antimicrobial resistance4) Presents novel approaches, such as engineering probiotics for enhanced antimicrobial activity5) Focuses on personalized probiotics and their role in bridging the gap between antimicrobial resistance and nutritional precision6) Examines safety considerations and regulatory frameworks for probiotics in the context of antimicrobial resistance

It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections.

It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections.

Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts.

Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts.