Click Chemistry in Drug Discovery and Biomedicine

Mohmmad Younus Wani is associate professor of Organic and Medicinal Chemistry in the College of Science, University of Jeddah, Jeddah, Saudi Arabia. He received his Ph.D. in Organic and Medicinal Chemistry from Jamia Millia Islamia, New Delhi, India, and Postdoctoral training from the University of Coimbra, Portugal, and Texas Therapeutics Institute, UTHealth, Houston, Texas, USA on the development of new treatment strategies and non-traditional approaches to combat antimicrobial drug resistance (AMR). With extensive experience in the field of medicinal chemistry and drug discovery, he has authored/co-authored over 90 peer-reviewed research articles 8 books, several US patents, and is the recipient of many prestigious honors, awards, and grants. He is a professional member of many scientific societies and is on the editorial board of many reputed scientific journals. Dr. Wani is working at the interface of chemistry and biology to develop novel small molecule inhibitors, new treatment strategies and novel approaches that could circumvent AMR, which is within the ambit of WHO’s global action plan on antimicrobial resistance.Anthony J. Burke is an associate professor (with habilitation 2012, and PhD 1993) of pharmaceutical chemistry at the faculty of pharmacy University of Coimbra, and a Chemistry Europe Fellow (class of 2020). He has worked in various institutions, ranging from University College Dublin, Oxford University, ITQB (Oeiras) and at the Chemistry and Biochemistry department at the University of Évora. In terms of books, articles, editorials, patents, talks amongst others, he has more than 200 outputs. He has been the coordinator of three major projects in the area of chemical synthesis and catalysis and has a key interest in the use of deep eutectic solvents for asymmetric organocatalysis. He has trained over 70 students, ranging from post-docs to PhD and MSc students. He is the chair of the International Symposium on Synthesis and Catalysis (ISySyCat) conference series and has been on the evaluation panels of numerous international and national grant selection boards. He is also the founder of ChiraTecnics (www.chiratecnics.com).

• Chapter 1: Click Chemistry in Drug Discovery: History and Applications. Chapter 2: Click Chemistry based on Cycloadditions: Principles, Concepts and Mechanisms. Chapter 3: Beyond Cycloadditions: Non-Cycloaddition Click Reactions in Drug Discovery and Biomedicine.Chapter 4: Controlled Click Chemistry for Modular Assembly: Selectivity, Orthogonality, and Protection of Clickable Functional Groups. Chapter 5: Exploring Bioorthogonal Click Reactions in Biological Systems. Chapter 6: Triazole Synthesis via Click Chemistry: Evolution and Applications in Drug Discovery. Chapter 7: Click Chemistry derived 1,2,3-Triazole based Bioactive Molecules. Chapter 8: Precision by Design: Click Chemistry’s Role in Targeted Therapeutics. Chapter 9: Click-driven Approaches for Cancer Drug Development. Chapter 10: Integrating Click Chemistry in Biomarker-Driven Cancer Therapies. Chapter 11: Computational Approaches and Click Chemistry in Targeted Therapeutic Design. Chapter 12: The Roadmap of Click Chemistry for Protein Bioconjugation and Labeling. Chapter 13: Click Chemistry for Peptide Therapeutics and Antibody-Drug Conjugates. Chapter 14: Advances in Drug Delivery Systems: The Role of Click Chemistry. Chapter 15: Click Chemistry for the Creation of Functionalised Polymersomes. Chapter 16: Click Chemistry for the Creation of Functional Nanomaterials. Chapter 17: Click Chemistry in Tissue Engineering and Regenerative Medicine. Chapter 18: Click Chemistry as a Tool for Advancing Tissue Engineering and Regenerative Therapies. Chapter 19: Challenges and Future Prospects: The Role of Click Chemistry in Drug Discovery and Biomedicine.