Muhammad Akram – författare

Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases

Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.

This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals.

The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of:

Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases

Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.

This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals.

The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of:

Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

This book describes a set of hybrid fuzzy models showing how to use them to deal with incomplete and/or vague information in different kind of decision-making problems. Based on the authors’ research, it offers a concise introduction to important models, ranging from rough fuzzy digraphs and intuitionistic fuzzy rough models to bipolar fuzzy soft graphs and neutrosophic graphs, explaining how to construct them. For each method, applications to different multi-attribute, multi-criteria decision-making problems, are presented and discussed. The book, which addresses computer scientists, mathematicians, and social scientists, is intended as concise yet complete guide to basic tools for constructing hybrid intelligent models for dealing with some interesting real-world problems. It is also expected to stimulate readers’ creativity thus offering a source of inspiration for future research.

This book offers a comprehensive perspective of herbal medicine phytochemistry and explores the application of plant extracts as bioactive compounds in disease prevention and treatment in modern or traditional medicine. The book starts with an introduction to the history and value of herbal medicine, followed by 3 parts covering the main phytochemical components and metabolites in herbal medicine, different uses and practices in herbal medicine, including a region-wise analysis of methods and practices and an overview of regulations and policies for herbal medicinal practitioners, and the advances and challenges in quality assessment of herbal medicine.

Plants generally have the tendency to bioaccumulate trace metals from the environment and they are easily contaminated by microorganisms from water sources and poor hygiene practices of the herbalist. Quality assessment and assurance is, thus, a pertinent challenge in herbal medicine practice (i.e., in remedy formulation and application), and this book offers an authoritative perspective on this topic, covering aspects such as quality control strategies, preparation techniques, chemical quantification in phytomedicine, and the efficacy and safety of herbal remedies. Moreover, in this book, readers will find valuable insights into the latest trends and developments in the field, and a critical review of the application of medicinal plants to treat cardiovascular, digestive, respiratory neurological and reproductive diseases. Particular attention is given to the advances and trends in the field, and readers will learn about the latest biotechnological approaches, the use of nanotechnology in herbal medicine, metabolomic analysis of medicinal plants, big data application in herbal medicine, and the value of herbal medicine towards sustainability.

Given its breadth, this book is aimed at researchers, academics, practitioners and professionals working in the fields of natural, life, health, clinical, and biomedical sciences, and interested in herbal remedies, pharmacology, pharmacognosy, human nutrition and dietetics, plant biology, and biotechnology/microbiology.

This book presents an extension of fuzzy set theory allowing for multi-polar information, discussing its impact on the theoretical and practical development of multi-criteria decision making. It reports on set of hybrid models developed by the authors, and show how they can be adapted, case by case, to the lack of certainty under a variety of criteria. Among them, hybrid models combining m-polar fuzzy sets with rough, soft and 2-tuple linguistic sets, and m-polar hesitant fuzzy sets and hesitant m-polar fuzzy are presented, together with some significant applications.  In turn, outranking decision-making techniques such as m-polar fuzzy ELECTRE I, II, III and IV methods, as well as m-polar fuzzy PROMETHEE I and II methods, are developed. The efficiency of these decision-making procedures, as well as other possible extensions studied by the authors, is shown in some real-world applications.  Overall, this book offers a guide on methodologies to deal with the multi-polarity and fuzziness of the real-world problems, simultaneously. By including algorithms and computer programming codes, it provides a practice-oriented reference guide to both researchers and professionals working at the interface between computational intelligence and decision making.

This handbook offers a comprehensive perspective of edible mushrooms'' phytochemistry and explores the application of bioactive compounds from fungi in nutrition, medicine, and environmental sustainability. The book starts with an overview of edible mushrooms'' bioactive compounds, followed by 5 parts covering the diversity, classification and taxonomy of common edible mushrooms, their environmental roles, sustainable harvesting practices, nutritional value and health benefits, and characterization and quality control of bioactive compounds. The book concludes with a perspective on emerging uses and trends in mushroom consumption utilization.

In this book, readers will find valuable insights into the latest trends and developments in the field, including how diverse edible mushroom species are used in culinary, medicinal, and ecological contexts. Particular attention is given to functional foods and the chemical composition of an extensive range of bioactive compounds in edible mushrooms, such as beta-glucans, polysaccharides, ergosterol, phenolic compounds, and triterpenoids. The book also explores the environmental impact of mushroom cultivation and the economic opportunities arising from the increasing demand for edible mushrooms and their bioactive compounds. Techniques and strategies for preserving mushrooms, detecting adulteration in the mushroom market, characterizing bioactive compounds, and ensuring quality control in production and distribution are thoroughly discussed.

This comprehensive overview serves as an invaluable resource for a wide range of professionals, including researchers, healthcare practitioners, nutritionists, food technologists, and anyone interested in tapping into the potential of edible mushroom bioactive compounds for the improvement of health, nutrition, and sustainability.

This book presents the fundamental and technical concepts of fuzzy hypergraphs and explains their extensions and applications. It discusses applied generalized mathematical models of hypergraphs, including complex, intuitionistic, bipolar, m-polar fuzzy, Pythagorean, complex Pythagorean, and q-rung orthopair hypergraphs, as well as single-valued neutrosophic, complex neutrosophic and bipolar neutrosophic hypergraphs. In addition, the book also sheds light on real-world applications of these hypergraphs, making it a valuable resource for students and researchers in the field of mathematics, as well as computer and social scientists.

This monograph discusses decision making methods under bipolar fuzzy graphical models with the aim of overcoming the lack of mathematical approach towards bipolar information—positive and negative. It investigates the properties of bipolar fuzzy graphs, their distance functions, and concept of their isomorphism. It presents certain notions, including irregular bipolar fuzzy graphs, domination in bipolar fuzzy graphs, bipolar fuzzy circuits, energy in bipolar fuzzy graphs, bipolar single-valued neutrosophic competition graphs, and bipolar neutrosophic graph structures. This book also presents the applications of mentioned concepts to real-world problems in areas of product manufacturing, international relations, psychology, global terrorism and more, making it valuable for researchers, computer scientists, social scientists and alike.