Nadey S. Hakim - Böcker

Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreas transplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life. This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation.

Over the last quarter of a century, the fields of medical ethics and of legal issues related to medical practice have rapidly developed for a number of reasons. Firstly, the provision of healthcare nowadays is based on a complicated partnership between healthcare providers, patients, administrators and organizations responsible for providing finance; this complicated partnership frequently results in clashes of views, opinions, and priorities, which have a major ethical and legal dimension. Secondly, a major event of the 21st century is the development of multicultural societies; healthcare-related decisions thus have to be made on the background of so many different ethnicities, religions, cultures and languages, resulting in a great spectrum of ethical and legal implications. Thirdly, in the modern world, people are more mobile and can easily and cost-effectively seek treatment outside of their country of origin or residence, which raises many ethical and legal issues. Lastly, the development of new medical specialties, modern and advanced treatments for very challenging patients, and the introduction of new technologies in medical practice have dramatically broadened the spectrum of ethical and legal issues related to medical practice. This book will therefore aim to cover in detail general principles and specific issues related to the ethical and legal dimensions of modern surgical practice.

The book is designed to highlight recent updates in living related transplants, with chapters by leaders in the different types of transplantation. There are very few texts that tackle living donor liver, lung, pancreas and intestinal transplantation as well as the connected ethical issues. With some color photographs illustrating procedures, this concise book will be a valuable resource for students or professionals interested in developing a global view of the ethics and practice of transplantation.

Over the last two decades, obesity has reached epidemic proportions in the world, resulting in suffering and premature death. Morbid obesity is a chronic medical illness that has long-reaching consequences and is caused by multiple factors. Bariatric surgery and other non-invasive procedures in carefully selected patients are effective treatments for obesity. It is the only tool for sustained and effective long-term weight loss.The field of surgery is developing rapidly — offering innovative options for patients who have failed to lose weight by diet, exercise and pharmacological methods. The editors review problems that the patients face in the perioperative period and in the long term, as well as their adjustments in lifestyle and healthcare management.The text is authored by authorities who participate in the multidisciplinary care of bariatric patients. It will address the assessment and selection of patients' treatment before surgery, options for surgical intervention and postoperative medical management.

This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. There is a 13-year gap between the first and second edition, and this is highlighted in the new collection of chapters of this updated version. This is a timely publication produced in line with the rapidly advancing field of transplantation.The editor, Nadey S Hakim, is a consultant transplant and general surgeon at Imperial College Healthcare NHS Trust, London, England, and has put together this second volume that will serve as an invaluable guide for transplant surgeons as well as trainees.

Artificial organs have come a long way since the first dialysis machine, the rotating artificial kidney, was invented in 1944 by Willem Johan Kolff, who is known as the ‘‘father of artificial organs’’. At that time he met stiff resistance from his hospital superiors but his persistence paid off and a million saved lives have been attributed to his first invention. He was indeed the first to mix medicine and engineering. An artificial organ is any machine, device, or other material that is used to replace the functions of a faulty or missing organ or other parts of the human body. Some body parts are more of a challenge than others. The heart has one purpose and it is to pump blood; however, the liver has biochemical and physiological functions which are difficult to simulate. The implantation of an artificial organ is critical because of the patient life dependency on the artificial organ itself. The treatment of choice is organ transplantation, however, transplant candidates face a long waiting time and many die while on the waiting list. In addition there are patients who are excluded from transplantation because of age or presence of other diseases. This book p- sents an overview of the current state of knowledge of artificial organs including the liver, pancreas, kidney, heart, cochlea, skin, stem cells, composite tissue allograft, and sphincters.

Artificial organs have come a long way since the first dialysis machine, the rotating artificial kidney, was invented in 1944 by Willem Johan Kolff, who is known as the ‘‘father of artificial organs’’. At that time he met stiff resistance from his hospital superiors but his persistence paid off and a million saved lives have been attributed to his first invention. He was indeed the first to mix medicine and engineering. An artificial organ is any machine, device, or other material that is used to replace the functions of a faulty or missing organ or other parts of the human body. Some body parts are more of a challenge than others. The heart has one purpose and it is to pump blood; however, the liver has biochemical and physiological functions which are difficult to simulate. The implantation of an artificial organ is critical because of the patient life dependency on the artificial organ itself. The treatment of choice is organ transplantation, however, transplant candidates face a long waiting time and many die while on the waiting list. In addition there are patients who are excluded from transplantation because of age or presence of other diseases. This book p- sents an overview of the current state of knowledge of artificial organs including the liver, pancreas, kidney, heart, cochlea, skin, stem cells, composite tissue allograft, and sphincters.

This introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine.The editor, Nadey S Hakim, is a consultant transplant and general surgeon at St Mary's Hospital, London, England, and has put together a volume that will serve as an invaluable guide for transplant surgeons as well as trainees.

The incidence of treated end stage renal disease (ESRD) continues to rise, particularly in the western world. Although renal transplantation is the treatment of choice for ESRD, the decline in the number of cadaveric organs, coupled with the rising demand for transplantation, means that an increasing number of patients will have to depend on dialysis. Vascular or peritoneal access is the Achilles' heel of any dialysis service.This book offers a clear description of the state of the art in providing and preserving a durable and reliable access. It also points the way to dialysis in the 21st century. The contributing authors are drawn from a wide background, with expertise in various aspects of dialysis access, including its history, the technique of placement, anaesthesia, radiology, nursing care and training of vascular access surgeons.There is currently a dearth of books on the subject of dialysis access. The few existing books on vascular access were written in the United States, with none from the UK. This volume is intended for use by transplant surgeons, general surgeons with an interest in vascular access, vascular surgeons, nephrologists, trainees and nurses. Dialysis services are expanding worldwide and this book is an invaluable guide for those involved in daily patient care and organisation of dialysis services.

Organ transplantation is the greatest therapeutic advancement of the second half of the 20th century. Of all medical specialities, the pioneers of transplantation make up the largest number of experts awarded with, or nominated for the Nobel Prize.Over the years, transplantation has fascinated the scientific community as well as the general public for a variety of reasons:• The development of transplantation has involved almost all medical specialities. In the history of medicine, there is perhaps no other example of such extensive co-operation and exchange of knowledge and experience among basic scientists, surgeons and physicians in achieving a common goal.• The progress of transplantation has forced doctors to “rewrite” medical textbooks dealing with a great spectrum of post-transplantation issues, such as the physiology of transplanted organs, the recurrence of initial disease in the transplanted organs, and the complications arising from immunosuppressive drugs, infectious diseases and cancer. Other issues raised concern maternity, child development, geriatric medicine and ethical issues.However, the history of this amazing field of modern medicine has never been thoroughly reported in a detailed textbook. History of Organ and Cell Transplantation covers this area of modern literature. It includes a foreword written by Lady Jean Medawar who is the wife of the late Sir Peter Medawar, Nobel Prize winner and first president of the International Transplantation Society.

The first textbook of its kind dealing with composite tissue allograft and allograft transplantation, provides an excellent overview on the subject. It provides a clear description of the current status of the transplant of every composite tissue allograft already performed and others which are still at the basic experimental level.The editors of the book, who also contribute chapters in their expertise, are world renowned surgeons. This book opens with an introductory chapter on the history of this type of transplantation and then details the clinical experience in each graft such as hand, larynx, face, uterus and the related histopathology, immunosuppression and immunomodulation.A multidisciplinary and comprehensive presentation of the various aspects of this new area of transplantation will allow the reader to understand the complexity and the challenges of composite tissue transplantation. A number of important topics are analyzed and discussed in detail, such as the ethical, medicolegal, psychological and immunological implications. New rehabilitation techniques and strategies, together with innovative tools for the functional evaluation of the transplanted parts, are highlighted. A section on the experimental work underlines what lies ahead of us.

This unique volume presents the cutting edge of haemostasis in surgery and includes the advances in the science pertaining to related important medical and surgical problems. It is the only book that includes all the surgical subspecialties focusing specifically on the problems of haemostasis in each field. State-of-the-art laboratory and clinical reviews are included and modern devices used in the different specialties are also covered. The contributors are well-known authorities in their special fields and haematological area. Each is covered comprehensively with special emphasis on unanswered questions. The book is addressed to all surgeons and physicians with an interest in this exciting field.