Parvin Mehdipour – författare

Now in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype.   Split in four parts, it starts with a comprehensive introduction covering the molecular cytogenetic basics, the role of ethic committees and international quality control in the field of diagnostics. The main parts II and III show the spectrum of different types of chromosomal abnormalities by a combination of karyogram and ideogram. They compare the significance of different banding techniques, give the karyotype formula and describe morphological peculiarities of each case presented. The final part provides a detailed description of non-coding DNA variants and focuses on potential problems in the detection of aberrations. It also mentions necessary additional investigations and peculiarities to be considered when counselling carriers of a chromosomal aberration or their relatives.Given its comprehensive scope and practical approach, this atlas is an indispensable resource for researchers, clinicians and practitioners working in the field of cytogenetics and clinical genetics.

Now in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype.   Split in four parts, it starts with a comprehensive introduction covering the molecular cytogenetic basics, the role of ethic committees and international quality control in the field of diagnostics. The main parts II and III show the spectrum of different types of chromosomal abnormalities by a combination of karyogram and ideogram. They compare the significance of different banding techniques, give the karyotype formula and describe morphological peculiarities of each case presented. The final part provides a detailed description of non-coding DNA variants and focuses on potential problems in the detection of aberrations. It also mentions necessary additional investigations and peculiarities to be considered when counselling carriers of a chromosomal aberration or their relatives.Given its comprehensive scope and practical approach, this atlas is an indispensable resource for researchers, clinicians and practitioners working in the field of cytogenetics and clinical genetics.

Der Chromosomen Atlas dient als diagnostischer Leitfaden bei der Analyse des menschlichen Karyotyps.Das Buch ist in vier Teile gegliedert. Es beginnt in Teil I mit einer Einführung und Eingruppierung von Menschen mit Behinderung in Vergangenheit und Gegenwart. Es folgen Darstellungen zu ethischen Prinzipien, die Vorgaben zur Qualitätskontrolle und die Möglichkeiten zur Weiterbildung im Fach Humangenetik.Die Hauptteile II und III zeigen das Spektrum von strukturellen Chromosomenaberrationen, dargestellt durch die Kombination von Karyogramm und Ideogramm. Die Bedeutung der Anwendung verschiedener Bandentechniken wird erläutert sowie die morphologischen Besonderheiten jedes Falles und ihre diagnostische Bedeutung. Der folgende Abschnitt enthält eine Beschreibung der Typen nicht kodierender DNA-Varianten und ihre Relevanz für den Träger und seine Nachkommen.Im vierten Teil (IV) werden zunächst die Bedeutung eines aberranten Karyotyps im Rahmen der genetischen Beratung für die Merkmalsträger und ihre Angehörigen an Hand von Beispielen veranschaulicht. Es folgen Darstellungen zur individuellen Entwicklung von Probanden über Jahre und Jahrzehnte. Daran anschließend wird auf die Rolle von Selbsthilfegruppen für Ratsuchende und ihre Angehörigen veranschaulicht.Abschließend wird kurz auf die heute zur Verfügung stehenden Untersuchmethoden und die sich abzeichnenden Neuentwicklungen eingegangen. Sein praktischer Ansatz und Umfang macht diesen Atlas zu einer unverzichtbaren Ressource für Wissenschaftler und medizinisches Fachpersonal der Zytogenetik und klinischen Genetik.

The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients’ style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided.  The initial insight of sections includes:1)    Brief classifications and key points of clinical and histopatological aspects of each organ.2)    Brief view of genetic alterations in each organ. 3)    Therapeutic aspects.4)    Brief classifications and key points of Psychology in cancer.5) The interactions of clinical aspects with psychological field.

Timing, racing, combating, struggling and targeting are some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that ‘telomeres are messengers of NATURE’, let’s to know them as they are.

Timing, racing, combating, struggling and targeting are some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that ‘telomeres are messengers of NATURE’, let’s to know them as they are.

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.