Peter J. Ell – författare

This volume is based on a series of lectures delivered at a one-day teach­ ing symposium on functional and metabolic aspects of NMR measure­ ments held at the Middlesex Hospital Medical School on 1st September 1985 as a part of the European Nuclear Medicine Society Congress. Currently the major emphasis in medical NMR in vivo is on its poten­ tial to image and display abnormalities in conventional radiological im­ ages, providing increased contrast between normal and abnormal tissue, improved definition of vasculature, and possibly an increased potential for differential diagnosis. Although these areas are undeniably of major importance, it is probable that NMR will continue to complement con­ ventional measurement methods. The major potential benefits to be de­ rived from in vivo NMR measurements are likely to arise from its use as an instrument for functional and metabolic studies in both clinical re­ search and in the everyday management of patients. It is to this area that this volume is directed.

This volume is based on a series of lectures delivered at a one-day teach­ ing symposium on functional and metabolic aspects of NMR measure­ ments held at the Middlesex Hospital Medical School on 1st September 1985 as a part of the European Nuclear Medicine Society Congress. Currently the major emphasis in medical NMR in vivo is on its poten­ tial to image and display abnormalities in conventional radiological im­ ages, providing increased contrast between normal and abnormal tissue, improved definition of vasculature, and possibly an increased potential for differential diagnosis. Although these areas are undeniably of major importance, it is probable that NMR will continue to complement con­ ventional measurement methods. The major potential benefits to be de­ rived from in vivo NMR measurements are likely to arise from its use as an instrument for functional and metabolic studies in both clinical re­ search and in the everyday management of patients. It is to this area that this volume is directed.

Specialists in cardiac imaging offer their extensive experience of performing and interpreting myocardial perfusion studies with thallium 201 and single photon emission tomography in this unique teaching atlas which contains over 1500 colour illustrations.

Specialists in cardiac imaging offer their extensive experience of performing and interpreting myocardial perfusion studies with thallium 201 and single photon emission tomography in this unique teaching atlas which contains over 1500 colour illustrations.

Recent explorations in the neurosciences have been progressing towards an understanding of the relationship between brain struc­ ture and brain function. Having passed through an era which may be described as one of a localisationist philosophy, in which discrete brain areas were seen to subserve only discrete functions, the perspective of brain-behaviour relationships has advanced in recent years to an appreciation that a more holistic approach is not only heuristically valid, but is also most likely to lead to future advances. The close relationship between the mind and the brain has been appreciated since the time of Hippocrates when he opined ''men ought to know that from nothing else but thence [from the brain] comes joys, delights, laughter and sports, and sorrows, griefs, despondency and lamentations ... and by this same organ we become mad and delirious and fears and terrors assail us''. In the nineteenth century, particularly in France and Germany, descrip­ tions of what are now recognised to be independent neurological diseases emerged following empirical clinical observations. Investi­ gation led to the identification in many cases of underlying struc­ tural abnormalities which could be linked to pathological changes.

Recent explorations in the neurosciences have been progressing towards an understanding of the relationship between brain struc­ ture and brain function. Having passed through an era which may be described as one of a localisationist philosophy, in which discrete brain areas were seen to subserve only discrete functions, the perspective of brain-behaviour relationships has advanced in recent years to an appreciation that a more holistic approach is not only heuristically valid, but is also most likely to lead to future advances. The close relationship between the mind and the brain has been appreciated since the time of Hippocrates when he opined 'men ought to know that from nothing else but thence [from the brain] comes joys, delights, laughter and sports, and sorrows, griefs, despondency and lamentations ... and by this same organ we become mad and delirious and fears and terrors assail us'. In the nineteenth century, particularly in France and Germany, descrip­ tions of what are now recognised to be independent neurological diseases emerged following empirical clinical observations. Investi­ gation led to the identification in many cases of underlying struc­ tural abnormalities which could be linked to pathological changes.

In this volume an account is given of the technologies relevant to the detection of sentinel lymph nodes in the context of surgical oncology. This is a rapidly and evolving field, and the clinical applications discussed in this volume are exciting and important. A multidisciplinary team was assembled to discuss this subject in the light of direct experience gained by each of the groups in the previous 12 months. Clinical case material is presented and the methodology of sentinel lymph node imaging and detection is discussed in detail. The authors have assembled in a single volume a significant amount of personal data and a comprehensive literature review which will serve as a single reference and teaching source for all those interested in this critical technique relevant to the management of large numbers of patients in surgical oncology.