Rina Rani Ray - Böcker

Microbial Biofilms: Challenges and Advances in Metabolomic Study is a volume in the Advances in Biotechnology and Bioengineering Series. The volume covers the metabolomic characteristics of bacterial biofilms and examines the techniques used in the analysis of the metabolomics of the biofilm, its formation, and related infections. The book includes the metabolomics study of various types of biofilms and details new strategies in targeting metabolic pathways for inhibiting the biofilm.

The book also describes various types of metabolomics studies like metabolomics of oral biofilm and metabolomics of biofilm by nosocomial microbes. It also points out the recent advancements on various aspects of metabolomics studies pertaining to biofilms, related infections, their pathogenesis, and present-day treatment strategies.

Microbial Biofilms: Challenges and Advances in Metabolomic Study is a helpful resource to scientists and researchers engaged in biofilm studies, precisely on the metabolomic changes at molecular level occurring in the participating microorganisms. It is also fascinating and thought provoking for the clinicians and health professionals actively involved in the treatment of biofilm mediated chronic infections, since it depicts the pathogenic consequences of the small molecular interactions of the metabolites in biofilm.

Discusses recent trends in biofilms researchDetails newer strategies in treating the biofilm by targeting metabolic pathwaysCovers chronic infections caused by biofilm and their metabolomics studiesExamines various analytical aspects on the metabolomics study of biofilm as well as how metabolomics regulate the formation of the biofilmIncorporates relevant case studies

A biofilm is a collection of microbial cells that have adhered to biotic surfaces such as plant cuticles or animal epithelia, as well as abiotic surfaces such as rocky substratum or catheter exteriors. The life cycle of a microorganism includes the fundamental process of biofilm formation for survival in diverse and harsh environments since it is a protected mode of growth allowing colonisation of new habitats by dispersal of microbes from the microbial clusters. The biofilm bound microorganisms remain embedded in an extracellular polymeric matrix that protects the indwelling cells from surfactants, biocides, several invaders like protozoans, and defences offered by the hosts like phagocytic cells. The biofilm bound recalcitrant microbes induce chronic and nosocomial diseases, posing a serious threat to public health. It has been observed that various antimicrobial drugs are able to successfully remove the planktonic (freely suspended) states of microbes as compared to the sessile (substrate-bound) forms, thus resulting in the development of antimicrobial resistance.Modern pharmacological strategies targeting the biofilm matrix differ from the conventional methods of antibiotic usage. This includes the use of natural compounds such as plant bioactive molecules, antimicrobial peptides, green synthesised nanoparticles, or secondary metabolites from other organisms that not only prevent the rise of antimicrobial resistance but are also safe for the host tissues.Biofilm Associated Antimicrobial Resistance and Its Recovery provides a detailed and systematic review of alternative pharmacological developments in the field of biofilm research.Features:A narrative overview of the mechanism of biofilm formation and its role in the emergence of antimicrobial resistanceRecent research in the development of antibiofilm remedies involving biogenic compoundsAdvancements in biofilm detection methodologies with cutting-edge technologiesThis book serves as a resource for researchers who need to understand and analyze the progression of events during microbial biofilm formation, as well as design safer methodologies for its successful eradication. It may also be used as a textbook for a graduate level course in microbiology or microbial biotechnology.

This book comprehensively reviews the interplay between hormones and biofilms, uncovering the complex ways in which hormonal signals impact microbial communities and the formation of biofilms. It begins with an introductory overview of hormones and reveals the dynamic nature of biofilm formation and its regulation, emphasizing the adaptability of biofilms to hormonal influences. The book also explores the role of hormones in quorum sensing among both Gram-positive and Gram-negative bacteria, illustrating how bacterial communities harness hormone signals to coordinate their behavior and form biofilms. It explores various types of hormones, including peptide hormones, stress hormones, phytohormones, calcium and sugar-regulating hormones, sex hormones, enteric hormones, catecholamines, and melatonin, and their specific roles in biofilm formation and regulation. Each chapter provides insights into the regulatory factors behind biofilm formation, offering a detailed look at the biochemical pathways involved and their potential implications for understanding bacterial behavior and resistance mechanisms. Additionally, the book discusses the implications of hormonal drugs on biofilms, opening new avenues for biomedical research and therapeutic strategies. This book is an important resource for researchers, academicians, and professionals in microbiology, endocrinology, biotechnology, and environmental sciences.Key Features:Explores the complex interplay between hormones and microbiota composition, emphasizing the influence of hormonal levels on microbial diversity and biofilm dynamicsHighlights the dynamic and adaptable nature of biofilm formation and its regulation by hormonal signalsDetails the significant role of hormones in quorum sensing among bacteria, illustrating how microbial communities utilize hormonal signals for coordinated behaviorUncovers regulatory factors behind biofilm formation, providing a deep dive into the biochemical pathways that facilitate biofilm developmentDiscusses implications of hormonal drugs on biofilms, highlighting potential targets for combating biofilm-associated infections and their applications

This book reviews the current concepts in biofilm formation and its implications in human health and disease. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention.

This book reviews the current concepts in biofilm formation and its implications in human health and disease. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention.

The book discusses biofilms and adherent communities of microorganisms that play a significant role in livestock-associated infections. It explores the characteristics, formation, and consequences of biofilms in various livestock species and explains their involvement in diseases like mastitis, Johne's disease, caseous lymphadenitis, and more. It also explains intricate aspects of biofilm-related challenges, such as virulence, antibiotic resistance, quorum sensing, and inter-species communication. The book then explores the strategies for combatting biofilm-associated infections, encompassing phytomedicines, novel antimicrobials, and nanomedicines.This book serves as a great resource for researchers, veterinary practitioners and students by addressing these critical issues and providing a comprehensive understanding of biofilm dynamics in livestock infections, fostering improved diagnosis and treatment methodologies.

This book examines the development and applications of system biology approaches for the prevention, diagnosis, and understanding of disease mechanisms. It explores the applications of system biology in infectious diseases, including host-pathogen interaction, and the identification of targets for new therapeutics and intervention strategies. It covers the use of system biology for understanding and treating metabolic disorders towards personalized and precision medicine. The book further discusses the systems biology approaches for understanding the mechanisms of tumor progression and designing more effective cancer therapies. The chapter also reviews the current strategies in autoimmune disease treatment and highlights the opportunity that systems biology represents for the development of better and safer treatments. Importantly, the book discusses the current state of the systems-level understanding of diseases and both the therapeutic and adverse mechanisms of drug actions usingsystem biology approaches. Cutting across the disciplines, this book is a valuable source for researchers in genetics, molecular biology, cell biology, microbiology, and biomedical sciences.​