Saghi Forouhi - Böcker

CMOS-based sensors offer significant advantages to life science applications, such as non-invasive long-term recordings, fast responses and label-free processes. They have been widely applied in many biological and medical fields for the study of living cell samples such as neural cell recording and stimulation, monitoring metabolic activity, cell manipulation, and extracellular pH monitoring. Compared to other sensing techniques, capacitive sensors are low-complexity, high-precision, label-free sensing methods for monitoring cellular activities such as cell viability, proliferation and morphology.The development of capacitive sensors for use in life sciences requires thorough knowledge of both the intended biological applications and CMOS circuitry. This book addresses the principles, design, implementation and testing, and packaging of CMOS circuits for these applications. Existing applications, markets, and potential future developments are also covered, plus the relevant biological protocols.Emerging CMOS Capacitive Sensors for Biomedical Applications provides information and guidance for researchers and advanced students in the field of microelectronics who are looking to specialise in biological applications. It is also relevant to academic and industrial researchers already working in the biosensors field, who wish to expand their knowledge and keep abreast of new developments.

Emerging complementary metal-oxide semiconductor (CMOS) technologies and their ongoing downscaling trend have opened an avenue to developing integrated systems for life sciences. They offer great advantages for the monolithic integration of several active elements, and the implementation of millions of biosensors along with their transducers and readout circuits on a single chip. Benefits include the ability to make highly dense systems with high signal-to-noise ratios (SNRs), good accessibility and reliability. Moreover, the huge investment in CMOS foundries and the possibility of the batch production of various devices using CMOS have established it as an economical technology appropriate for the fabrication of affordable platforms for end-users. All these features make CMOS electronics a valuable technology for the implementation of integrated bio-systems such as lab-on-chips (LoCs) and point-of-care (PoC) devices.This book offers deep multidisciplinary knowledge of different types of biosensors and bioactuators. The book covers the design and implementation of CMOS chips, including transducers, readouts and data equation circuitries. It also deals with microfluidic packaging techniques, and biological applications and protocols. The theoretical and practical aspects of CMOS biosensors are discussed, and the fundamentals of microfabrication. Several key life science applications are explored, including optical biosensors, thermal sensors, and a range of actuators.CMOS-Based Sensors and Actuators for Life Science Applications offers a systematic and thorough approach to this complex multidisciplinary topic for researchers and engineers working in the field of microelectronic design and development, particularly those whose work has life sciences applications.