Ebrahim Ghafar-Zadeh received his B.Sc. and M.Sc. in Electrical Engineering from the KNT University of Technology (Tehran, Iran) and University of Tehran (Tehran, Iran), respectively. He then continued his studies in Polytechnique of Montreal (Montreal, Canada), where he received his Ph.D. degree in Electrical Engineering in 2008. His graduate studies focused on complementary metal-oxide semiconductor (CMOS)-based sensors for lab-on-chip applications. In recognition of his research achievements, he received several fellowship awards including a Postdoctoral Fellowship (PDF) from the Natural Sciences and Engineering Research Council of Canada (NSERC). Then he continued his PDF research studies in Electrical Engineering at the McGill University (Montreal, Canada) and in Bioengineering, at the University of California, Berkeley. As Assistant Professor, in 2013, Ebrahim joined the Department of Electrical Engineering and Computer Science (EECS) in the Lassonde School of Engineering at York University where currently he is Associate Professor, Member of Graduate Programs of Departments of EECS and Biology, and Director of Biologically Inspired Sensors and Actuators (BioSA) research laboratory. His research is aimed at exploring novel integrated sensors and actuators for life science applications. Since 2013, Professor Ghafar-Zadeh has published more than 100 journal and conference articles and trained more than 40 highly qualified personnel (HQP) in the fields of Electrical Engineering and Biology. He is Senior Member of the IEEE and a licensed Professional Engineer in the province of Ontario.Saghi Forouhi is a postdoctoral researcher at York University (Department of Electrical Engineering and Computer Science (EECS), Biologically Inspired Sensors and Actuators (BioSA) Laboratory), Canada. She received the B.Sc. and M.Sc. degrees in Electrical Engineering from Guilan University, Iran, in 2010 and 2012, respectively. Then, she completed her Ph.D. at Isfahan University of Technology (IUT) in 2019 in an active collaboration between IUT and York University. Her research interests lie in the area of biologically inspired micro-systems, CMOS sensors, circuits, and systems.

• Chapter 1: IntroductionChapter 2: Design, implementation, and characterization of CMOS capacitive biosensorsChapter 3: MicroelectrodesChapter 4: CMOS interface circuits of capacitive biosensorsChapter 5: Microfluidic packagingChapter 6: Biological/chemical applicationsChapter 7: Current technology and future workAppendix A: Simulation of electrodesAppendix B: Fabrication techniquesAppendix C: Simulation of single-ended and fully differential core-CBCM CVCsAppendix D: Simulation of a core-CBCM CFCAppendix E: Cell culture

Ebrahim Ghafar-Zadeh received his B.Sc. and M.Sc. in Electrical Engineering from the KNT University of Technology (Tehran, Iran) and University of Tehran (Tehran, Iran), respectively. He then continued his studies in Polytechnique of Montreal (Montreal, Canada), where he received his Ph.D. degree in Electrical Engineering in 2008. His graduate studies focused on complementary metal-oxide semiconductor (CMOS)-based sensors for lab-on-chip applications. In recognition of his research achievements, he received several fellowship awards including a Postdoctoral Fellowship (PDF) from the Natural Sciences and Engineering Research Council of Canada (NSERC). Then he continued his PDF research studies in Electrical Engineering at the McGill University (Montreal, Canada) and in Bioengineering, at the University of California, Berkeley. As Assistant Professor, in 2013, Ebrahim joined the Department of Electrical Engineering and Computer Science (EECS) in the Lassonde School of Engineering at York University where currently he is Associate Professor, Member of Graduate Programs of Departments of EECS and Biology, and Director of Biologically Inspired Sensors and Actuators (BioSA) research laboratory. His research is aimed at exploring novel integrated sensors and actuators for life science applications. Since 2013, Professor Ghafar-Zadeh has published more than 100 journal and conference articles and trained more than 40 highly qualified personnel (HQP) in the fields of Electrical Engineering and Biology. He is Senior Member of the IEEE and a licensed Professional Engineer in the province of Ontario.Saghi Forouhi is a postdoctoral researcher at York University (Department of Electrical Engineering and Computer Science (EECS), Biologically Inspired Sensors and Actuators (BioSA) Laboratory), Canada. She received the B.Sc. and M.Sc. degrees in Electrical Engineering from Guilan University, Iran, in 2010 and 2012, respectively. Then, she completed her Ph.D. at Isfahan University of Technology (IUT) in 2019 in an active collaboration between IUT and York University. Her research interests lie in the area of biologically inspired micro-systems, CMOS sensors, circuits, and systems.

• Chapter 1: IntroductionChapter 2: Design, implementation, and characterization of CMOS capacitive biosensorsChapter 3: MicroelectrodesChapter 4: CMOS interface circuits of capacitive biosensorsChapter 5: Microfluidic packagingChapter 6: Biological/chemical applicationsChapter 7: Current technology and future workAppendix A: Simulation of electrodesAppendix B: Fabrication techniquesAppendix C: Simulation of single-ended and fully differential core-CBCM CVCsAppendix D: Simulation of a core-CBCM CFCAppendix E: Cell culture

Ebrahim Ghafar-Zadeh received his B.Sc. and M.Sc. in Electrical Engineering from the KNT University of Technology (Tehran, Iran) and University of Tehran (Tehran, Iran), respectively. He then continued his studies in Polytechnique of Montreal (Montreal, Canada), where he received his Ph.D. degree in Electrical Engineering in 2008. His graduate studies focused on complementary metal-oxide semiconductor (CMOS)-based sensors for lab-on-chip applications. In recognition of his research achievements, he received several fellowship awards including a Postdoctoral Fellowship (PDF) from the Natural Sciences and Engineering Research Council of Canada (NSERC). Then he continued his PDF research studies in Electrical Engineering at the McGill University (Montreal, Canada) and in Bioengineering, at the University of California, Berkeley. As Assistant Professor, in 2013, Ebrahim joined the Department of Electrical Engineering and Computer Science (EECS) in the Lassonde School of Engineering at York University where currently he is Associate Professor, Member of Graduate Programs of Departments of EECS and Biology, and Director of Biologically Inspired Sensors and Actuators (BioSA) research laboratory. His research is aimed at exploring novel integrated sensors and actuators for life science applications. Since 2013, Professor Ghafar-Zadeh has published more than 100 journal and conference articles and trained more than 40 highly qualified personnel (HQP) in the fields of Electrical Engineering and Biology. He is Senior Member of the IEEE and a licensed Professional Engineer in the province of Ontario.Saghi Forouhi is a postdoctoral researcher at York University (Department of Electrical Engineering and Computer Science (EECS), Biologically Inspired Sensors and Actuators (BioSA) Laboratory), Canada. She received the B.Sc. and M.Sc. degrees in Electrical Engineering from Guilan University, Iran, in 2010 and 2012, respectively. Then, she completed her Ph.D. at Isfahan University of Technology (IUT) in 2019 in an active collaboration between IUT and York University. Her research interests lie in the area of biologically inspired micro-systems, CMOS sensors, circuits, and systems.

• Chapter 1: IntroductionChapter 2: Design, implementation, and characterization of CMOS capacitive biosensorsChapter 3: MicroelectrodesChapter 4: CMOS interface circuits of capacitive biosensorsChapter 5: Microfluidic packagingChapter 6: Biological/chemical applicationsChapter 7: Current technology and future workAppendix A: Simulation of electrodesAppendix B: Fabrication techniquesAppendix C: Simulation of single-ended and fully differential core-CBCM CVCsAppendix D: Simulation of a core-CBCM CFCAppendix E: Cell culture