Scott L. Friedman – författare

This detailed volume explores hepatic stellate cells, which have become a spotlight of liver cell biology due to their pleiotropic functions that extend well beyond extracellular matrix production to pivotal roles in hepatic homeostasis, immunity, and metabolism.

This detailed volume explores hepatic stellate cells, which have become a spotlight of liver cell biology due to their pleiotropic functions that extend well beyond extracellular matrix production to pivotal roles in hepatic homeostasis, immunity, and metabolism.

Mount Sinai Expert Guides: Hepatology will provide gastroenterology and hepatology trainees with an extremely clinical and accessible handbook covering the major liver diseases and symptoms, their diagnosis and clinical management.   Perfect as a point-of-care resource on the hospital wards and also as a refresher for board exam preparation, the focus throughout is on providing rapid reference, essential information on each disease to allow for quick, easy browsing and assimilation of the must-know information.  All chapters follow a consistent template including the following features: - An opening bottom-line/key points section- Classification, pathogenesis and prevention of disease- Evidence-based diagnosis, including relevant algorithms, laboratory and imaging tests, and potential pitfalls when diagnosing a patient- Disease management including commonly used medications with dosages, when to perform surgery, management algorithms and how to prevent complications- How to manage special populations, ie, in pregnancy, children and the elderly- The very latest evidence-based results, major society guidelines (AASLD/EASL) and key external sources to consult In addition, the book comes with a companion website housing extra features such as case studies with related questions for self-assessment, key patient advice and ICD codes.  Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be. If you're specialising in hepatology and require a concise, practical guide to the clinical management of liver disease, bought to you by one of world's leading hospitals, then this is the perfect book for you.This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.