Subcommittee on Acute Exposure Guideline Levels – författare

This report provides technical guidance on establishing community Acute Exposure Guideline Levels (AEGLs) for certain hazardous chemicals. It reviews the scientific validity of AEGLs developed by the national Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances, identifies research priorities, and identifies guidance issues that may require modification or further development based on the toxicological database for the chemicals reviewed. This twelfth interim report offers recommendations for improving AEGLs for the following 15 chemicals: toluene, xylenes, ammonia, bromine, aniline, methyl ethyl ketone, hydrazine, iron pentacarbonyl, phosphine, chlorine, trifluoride, ethyleneimine, propyleneimine, allyl alcohol, ethylene oxide, and nickel carbonyl.

The Bhopal Disaster of 1984 resulted in the death of around 2,000 residents living near chemical plants and irreversible injuries to more than 20,000 other residents. These numbers can be attributed to the community''s lack of awareness concerning the chemicals'' existence, dangers and effects, and/or how to react in case of emergency. The disaster emphasized the need for governments to identify hazardous substances and to aid local communities in developing plans for emergency exposures.

As a result, the United States government issued the Superfund Amendments and Reauthorization Act (SARA) of 1986; requiring the identification of extremely hazardous substances (EHSs) by the Environmental Protection Agency (EPA). EPA was also tasked with assisting Local Emergency Planning Committees (LEPCs) in conducting health-hazard assessments to develop emergency-response plans for sites where EHSs are produced, stored, transported, or used. The EPA identified nearly 400 EHSs in terms of their immediate danger to life and health (IDLH) as their first step in assisting these LEPCs.

In 1991 the EPA went on to request that the National Research Council (NRC) Committee on Toxicology (COT) develop criteria and methods for developing emergency exposure levels for EHSs for the general population. The COT, who had published many reports on emergency exposure guidance levels at the time, designated the task to a subcommittee. The subcommittee focused on Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances. Four years later the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC) was created with a focus on identifying, reviewing, and interpreting relevant toxicologic and other scientific data and developing acute exposure guideline levels (AEGLs) for high-priority, acutely toxic chemicals.

In Acute Exposure Guideline Levels for Selected Airborne Chemicals:Volume 4, the NAC outlines acute exposure guideline levels for chlorine, hydrogen chloride, toluene 2,4, hydrogen fluoride, 2,6-diisocyanate, and uranium hexafluoride.

The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment.

It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routes—both oral and dermal—as well as risk assessors in the government, academe, and private industry.

This book reviews toxicity documents on five chemicals that can be released in the air from accidents at chemical plants, storage sites, or during transportation. The documents were prepared by the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances and were evaluated for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.

In the Bhopal disaster of 1984, approximately 2,000 residents living near a chemical plant were killed and 20,000 more suffered irreversible damage to their eyes and lungs following the accidental release of methyl isocyanate. This tragedy served to focus international attention on the need for governments to identify hazardous substances and assist local communities in planning how to deal with emergency exposures. Since 1986, the U.S. Environmental Protection Agency has been tasked with identifying extremely hazardous substances and, in cooperation with the Federal Emergency Management Agency and the Department of Transportation, assist local emergency response planners. The National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances was established in 1995 to develop acute exposure guideline levels (AEGLs) for high priority toxic chemicals that could be released into the air from accidents at chemical plants, storage sites, or during transportation. This book reviews toxicity documents on five chemicals—chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride—for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.

This report provides technical guidance on establishing community Acute Exposure Guideline Levels (AEGLs) for certain hazardous chemicals. It reviews the scientific validity of AEGLs developed by the national Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances, identifies research priorities, and identifies guidance issues that may require modification or further development based on the toxicological database for the chemicals reviewed. This twelfth interim report offers recommendations for improving AEGLs for the following 15 chemicals: toluene, xylenes, ammonia, bromine, aniline, methyl ethyl ketone, hydrazine, iron pentacarbonyl, phosphine, chlorine, trifluoride, ethyleneimine, propyleneimine, allyl alcohol, ethylene oxide, and nickel carbonyl.

In the Bhopal disaster of 1984, approximately 2,000 residents living near a chemical plant were killed and 20,000 more suffered irreversible damage to their eyes and lungs following the accidental release of methyl isocyanate. This tragedy served to focus international attention on the need for governments to identify hazardous substances and assist local communities in planning how to deal with emergency exposures. Since 1986, the U.S. Environmental Protection Agency has been tasked with identifying extremely hazardous substances and, in cooperation with the Federal Emergency Management Agency and the Department of Transportation, assist local emergency response planners. The National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances was established in 1995 to develop acute exposure guideline levels (AEGLs) for high priority toxic chemicals that could be released into the air from accidents at chemical plants, storage sites, or during transportation. This book reviews toxicity documents on five chemicals—chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride—for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.

This book reviews toxicity documents on five chemicals that can be released in the air from accidents at chemical plants, storage sites, or during transportation. The documents were prepared by the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances and were evaluated for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.

The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment.

It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routes—both oral and dermal—as well as risk assessors in the government, academe, and private industry.