Surajit Pathak – författare

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process.

With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.

Stem Cells and Signaling Pathways brings together chapters exploring the mechanism of stem cells and the signaling pathways. This book is a very concise and easy-to-use book. It serves as an ideal reference to guide investigators towards further valuable answers on the role of stem cells and will aid basic researchers and scientists in biomedical sciences and tissue engineering and regenerative medicine with a wide variety of interests in stem cell biology linking basic signal transduction for possible future therapies directed to treatments and different diseases.Significant information on signaling has been presented here. Sufficient knowledge has been provided on therapeutic approaches for the treatment of different degenerative disorders.

This book offers a comprehensive review of the multifaceted role of phytochemicals in promoting human health and combating diseases. The initial chapters introduce phytochemicals, navigate the natural health landscape, and provide a foundational understanding of these bioactive compounds. The book unfolds the role of phytochemicals as a formidable defense against oxidative stress and explores the unique health benefits and nutritional significance of phytochemicals found in fruit peels. The subsequent chapters further discuss the therapeutic potential of phytochemicals, detailing their role in combating multidrug-resistant bacterial infections and modulating critical pathways in inflammation and cancer. This book also highlights the novel treatment strategies for amyloidosis using natural products, as well as the fascinating interplay between natural compounds and biogenic nanoparticles in the context of polycystic ovarian syndrome (PCOS). Further exploration includes the impact of plant-derived compounds on cancer stem cells and the recent advancements in ethnopharmacology for age-related brain disorders. Each chapter provides a thorough and up-to-date analysis of research findings, clinical applications, and future directions within the field. By presenting a holistic view of the diverse functions and benefits of phytochemicals, this book aims to inspire further investigation and innovation in this dynamic area of research, ultimately contributing to enhanced human health and well-being.

This book offers a comprehensive review of the multifaceted role of phytochemicals in promoting human health and combating diseases. The initial chapters introduce phytochemicals, navigate the natural health landscape, and provide a foundational understanding of these bioactive compounds. The book unfolds the role of phytochemicals as a formidable defense against oxidative stress and explores the unique health benefits and nutritional significance of phytochemicals found in fruit peels. The subsequent chapters further discuss the therapeutic potential of phytochemicals, detailing their role in combating multidrug-resistant bacterial infections and modulating critical pathways in inflammation and cancer. This book also highlights the novel treatment strategies for amyloidosis using natural products, as well as the fascinating interplay between natural compounds and biogenic nanoparticles in the context of polycystic ovarian syndrome (PCOS). Further exploration includes the impact of plant-derived compounds on cancer stem cells and the recent advancements in ethnopharmacology for age-related brain disorders. Each chapter provides a thorough and up-to-date analysis of research findings, clinical applications, and future directions within the field. By presenting a holistic view of the diverse functions and benefits of phytochemicals, this book aims to inspire further investigation and innovation in this dynamic area of research, ultimately contributing to enhanced human health and well-being.

This book highlights the potential applications of microbots for minimally invasive diagnosis of colorectal cancer (CRC), enhancing the accuracy of colonoscopy and improving drug delivery for more precise and effective treatments. The introductory chapter explores advanced CRC diagnostic and therapeutic approaches, from understanding the disease’s prevalence to assessing the limitations of invasive techniques. It further discusses non-invasive screening methods and state-of-the-art imaging technologies, paving the way for less intrusive and more accessible diagnostics. The book, in turn, reviews techniques to tailor microbots for specifically targeting cancer cells effectively and provides a comparative analysis with nanobots for their potential in cancer diagnostics and therapeutics. It explores the intersection of photodynamic therapy and microrobotic technology, shedding light on the future of cancer therapy. With a focus on clinical translation, this book provides insight into the future application of mobile microrobots in medical imaging and in vivo perspectives of colorectal cancer, ultimately addressing the broader applications of bio-nanotechnology and microrobots in the realm of gastrointestinal diseases and cancer. This book is intended for researchers, students, and academicians in the fields of oncology, nanotechnology, and medical sciences.

Key Features

This book highlights the potential applications of microbots for minimally invasive diagnosis of colorectal cancer (CRC), enhancing the accuracy of colonoscopy and improving drug delivery for more precise and effective treatments. The introductory chapter explores advanced CRC diagnostic and therapeutic approaches, from understanding the disease’s prevalence to assessing the limitations of invasive techniques. It further discusses non-invasive screening methods and state-of-the-art imaging technologies, paving the way for less intrusive and more accessible diagnostics. The book, in turn, reviews techniques to tailor microbots for specifically targeting cancer cells effectively and provides a comparative analysis with nanobots for their potential in cancer diagnostics and therapeutics. It explores the intersection of photodynamic therapy and microrobotic technology, shedding light on the future of cancer therapy. With a focus on clinical translation, this book provides insight into the future application of mobile microrobots in medical imaging and in vivo perspectives of colorectal cancer, ultimately addressing the broader applications of bio-nanotechnology and microrobots in the realm of gastrointestinal diseases and cancer. This book is intended for researchers, students, and academicians in the fields of oncology, nanotechnology, and medical sciences.

Key Features

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer.

It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression.

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

The book discusses the role of gut microbiome composition in colorectal cancer progression, linking intestinal inflammation, tumorigenesis and anti-cancer immune responses. Chapters delve into various areas, including the mechanisms of action of probiotics and prebiotics (such as Lactobacillus and Bifidobacterium strains, and fructans and galactans, respectively), functional foods such as α-carotene, β-carotene, lutein, β-cryptoxanthin, fucoxanthin, isothiocyanates, flavonoids, probiotics, fibre and omega-3. Lycopene, β-cryptoxanthin, and fucoxanthin. Dietary phytochemicals such as polyphenols (curcumin, gingerol, ferulic acid (FA) and hydroxytyrosol); alkaloids (piperine, and protopine); terpenoids (artemisinin, and astaxanthin); iridoid glycoside (picroside II, and morroniside); and flavonoid (quercetin) on cancer, immune responses, and the gut microbiome. It examines the interaction and influence of prebiotics and probiotics in colorectal cancer treatment, their use in managing chemotherapy-related gastrointestinal problems, and their potential as adjuvants. The book also investigates how these gut microbes are associated with tumor progression and anti-cancer treatment efficacy. This knowledge can be used to develop biomarkers that predict immunotherapy effectiveness and improve treatment outcomes through modulation.

This book provides a comprehensive update on the latest research and clinical applications in the field, offering valuable insights into the complex interplay between probiotics, the gut microbiome, and colorectal cancer. It serves as an invaluable resource for healthcare professionals, researchers, and students seeking to understand this dynamic area of study.