Sushama Talegaonkar – författare

**Selected for 2026 Doody's Core Titles in Ophthalmology**Nanotechnology in Ophthalmology is a comprehensive and up-to-date reference on the role and applications of nanotechnology in ophthalmology, from drug delivery and treatment of ocular diseases to toxicity issues. Written by experts from the nanotechnology, ophthalmology, and pharmacology fields, this book has a unique, broad and diverse scope, including chapters on nanosensor-based diagnostic tools, delivery of nanobiomaterials, implantable materials and devices, delivery of nanobiomaterials, nanotechnology for medical and surgical treatment, regenerative medicine, and more. This book provides a valuable reference to researchers working in the areas of ophthalmology, nanoscience and pharmacology, and clinical fellows who are interested in nanoophthalmology as a reference for their practice and research.Provides a comprehensive review of the literature in the area of nanoophthalmologyDiscusses regenerative medicine, drug delivery, imaging, and medical device applicationsAnalyzes treatment strategies for emerging and multidrug-resistant ocular pathogens

**Selected for Doody''s Core Titles® 2024 in Ophthalmology**Nanotechnology in Ophthalmology is a comprehensive and up-to-date reference on the role and applications of nanotechnology in ophthalmology, from drug delivery and treatment of ocular diseases to toxicity issues. Written by experts from the nanotechnology, ophthalmology, and pharmacology fields, this book has a unique, broad and diverse scope, including chapters on nanosensor-based diagnostic tools, delivery of nanobiomaterials, implantable materials and devices, delivery of nanobiomaterials, nanotechnology for medical and surgical treatment, regenerative medicine, and more. This book provides a valuable reference to researchers working in the areas of ophthalmology, nanoscience and pharmacology, and clinical fellows who are interested in nanoophthalmology as a reference for their practice and research.- Provides a comprehensive review of the literature in the area of nanoophthalmology- Discusses regenerative medicine, drug delivery, imaging, and medical device applications- Analyzes treatment strategies for emerging and multidrug-resistant ocular pathogens

Concepts of Combating Chemoresistance in Cancer Therapeutics explores the fundamental issues and challenges related to cancer chemotherapeutics, emphasizing mechanisms and factors that lead to chemoresistance in various cancer types. This book provides current updates on novel paradigms and mechanisms responsible for cancer chemoresistance, presenting comprehensive information in 15 chapters. In addition to introducing principles, mechanisms, and monitoring strategies for cancer drug resistance, the book highlights the role of nanotechnology in diagnostics and point-of-care solutions for early detection, screening, and control. It is an invaluable resource for health professionals, scientists, researchers, and students seeking knowledge in this field.Covers current updates in the novel paradigms and mechanisms responsible for the cancer chemo-resistanceElucidates on the molecular mechanisms in diverse types of cancersProvides multi-model solutions for combating the multi-drug resistanceGives insights on newer advancements and concepts to improve the accumulation of nanotherapeutics in tumor microenvironment

Concepts of Combating Chemoresistance in Cancer Therapeutics explores the fundamental issues and challenges related to cancer chemotherapeutics, emphasizing mechanisms and factors that lead to chemoresistance in various cancer types. This book provides current updates on novel paradigms and mechanisms responsible for cancer chemoresistance, presenting comprehensive information in 15 chapters. In addition to introducing principles, mechanisms, and monitoring strategies for cancer drug resistance, the book highlights the role of nanotechnology in diagnostics and point-of-care solutions for early detection, screening, and control. It is an invaluable resource for health professionals, scientists, researchers, and students seeking knowledge in this field. - Covers current updates in the novel paradigms and mechanisms responsible for the cancer chemo-resistance- Elucidates on the molecular mechanisms in diverse types of cancers- Provides multi-model solutions for combating the multi-drug resistance- Gives insights on newer advancements and concepts to improve the accumulation of nanotherapeutics in tumor microenvironment

Advances in Tablet Manufacturing Technologies consolidates cutting-edge information on the latest technologies in tablet design and manufacturing, addressing the pressing need for innovation in an increasingly complex global market. The book is structured to provide a thorough understanding of tablet technology, beginning with foundational concepts and progressing through specialized topics. Key sections explore the historical context of tablet development, the significance of pharmaceutical excipients, preformulation aspects, and the physics of tablet compression. Subsequent chapters explore advanced topics, including coated tablets, modified-release formulations, organ-specific tablets, and state-of-the-art innovations like 3D printed tablets.Each chapter is enriched with practical examples and case studies, ensuring that readers can apply theoretical knowledge to real-world scenarios. With contributions from a diverse group of national and international experts, this book is an invaluable asset for scientists in academia and industry alike. It elucidates preformulation parameters, outlines regulatory frameworks, and discusses recent advances in excipient technology and in-process testing equipment.Provides comprehensive insights into advanced tablet manufacturing technologies for enhanced pharmaceutical product developmentCovers innovative excipients and technologies for improved tablet performance and patient outcomesExplores regulatory frameworks, ensuring compliance and quality in tablet productionIncludes practical case studies and examples to bridge theory and real-world application in tablet formulation

Advances in Tablet Manufacturing Technologies consolidates cutting-edge information on the latest technologies in tablet design and manufacturing, addressing the pressing need for innovation in an increasingly complex global market. The book is structured to provide a thorough understanding of tablet technology, beginning with foundational concepts and progressing through specialized topics. Key sections explore the historical context of tablet development, the significance of pharmaceutical excipients, preformulation aspects, and the physics of tablet compression. Subsequent chapters explore advanced topics, including coated tablets, modified-release formulations, organ-specific tablets, and state-of-the-art innovations like 3D printed tablets.Each chapter is enriched with practical examples and case studies, ensuring that readers can apply theoretical knowledge to real-world scenarios. With contributions from a diverse group of national and international experts, this book is an invaluable asset for scientists in academia and industry alike. It elucidates preformulation parameters, outlines regulatory frameworks, and discusses recent advances in excipient technology and in-process testing equipment. - Provides comprehensive insights into advanced tablet manufacturing technologies for enhanced pharmaceutical product development- Covers innovative excipients and technologies for improved tablet performance and patient outcomes- Explores regulatory frameworks, ensuring compliance and quality in tablet production- Includes practical case studies and examples to bridge theory and real-world application in tablet formulation

Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-?, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.Offers comprehensive insights into tissue-specific and tumor-specific molecular targets for cancer therapyExplores novel therapeutic strategies to enhance precision medicine in oncologyDiscusses the critical mediators that influence tumor immunity and therapeutic interventionsHighlights advanced approaches, including nanotechnology, for improved drug delivery systemsProvides practical applications for targeted therapies to optimize patient outcomes

Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology. - Offers comprehensive insights into tissue-specific and tumor-specific molecular targets for cancer therapy- Explores novel therapeutic strategies to enhance precision medicine in oncology- Discusses the critical mediators that influence tumor immunity and therapeutic interventions- Highlights advanced approaches, including nanotechnology, for improved drug delivery systems- Provides practical applications for targeted therapies to optimize patient outcomes

Role of Biomarkers in Cancer Diagnosis and Therapeutics offers a thorough exploration of the critical roles biomarkers play in cancer detection, diagnosis, monitoring, and therapy. Sections focus on established and emerging biomarkers like PSA and CEA, detailing their biochemical characteristics and clinical relevance, and examining metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic potential. The final part pf the book discusses innovative strategies targeting cell cycle checkpoints and DNA repair mechanisms, including synthetic lethality through PARP inhibitors. This essential resource provides researchers and clinicians with insights into novel metabolic targets and cutting-edge treatment strategies.By addressing current applications and future challenges, including the integration of AI and multi-omics approaches, the book equips readers with actionable knowledge to advance personalized cancer care and navigate the dynamic landscape of oncology.Provides an in-depth analysis of both established and emerging cancer biomarkers, detailing their biochemical characteristics, clinical relevance, and diagnostic potential across various malignanciesExplores critical metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic implications, thereby offering insights into novel targets for cancer treatmentDiscusses cutting-edge approaches that target cell cycle checkpoints and DNA repair mechanisms, including the concept of synthetic lethality, thus equipping readers with advanced knowledge for personalized cancer therapies

Role of Biomarkers in Cancer Diagnosis and Therapeutics offers a thorough exploration of the critical roles biomarkers play in cancer detection, diagnosis, monitoring, and therapy. Sections focus on established and emerging biomarkers like PSA and CEA, detailing their biochemical characteristics and clinical relevance, and examining metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic potential. The final part pf the book discusses innovative strategies targeting cell cycle checkpoints and DNA repair mechanisms, including synthetic lethality through PARP inhibitors. This essential resource provides researchers and clinicians with insights into novel metabolic targets and cutting-edge treatment strategies.By addressing current applications and future challenges, including the integration of AI and multi-omics approaches, the book equips readers with actionable knowledge to advance personalized cancer care and navigate the dynamic landscape of oncology. - Provides an in-depth analysis of both established and emerging cancer biomarkers, detailing their biochemical characteristics, clinical relevance, and diagnostic potential across various malignancies- Explores critical metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic implications, thereby offering insights into novel targets for cancer treatment- Discusses cutting-edge approaches that target cell cycle checkpoints and DNA repair mechanisms, including the concept of synthetic lethality, thus equipping readers with advanced knowledge for personalized cancer therapies

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

This contributed volume explores the innovative applications and transformative potential of carbon nanodots (CNDs) in revolutionizing human health, food security, and agriculture. Edited by leading experts, it provides a comprehensive overview of the synthesis methods and unique properties that establish CNDs as a groundbreaking innovation in nanotechnology.The chapters cover a broad range of topics, including the role of CNDs in drug delivery, antimicrobial resistance, and cancer therapy. Readers will learn how CNDs are advancing diagnostics through bioimaging and biosensors, offering new pathways for early disease detection. The book also highlights their applications in sustainable agriculture, such as enhancing crop growth, protecting crops from pathogens, and improving food preservation techniques. Through a detailed examination of the latest scientific breakthroughs, it provides insights into the practical applications and future potential of CNDs. Additionally, it presents an analysis of the challenges and opportunities in scaling up CND production, addressing critical questions related to safety, toxicity, and regulatory frameworks.This book serves as an invaluable resource for researchers, industry professionals, and students in fields such as nanotechnology, materials science, and biotechnology. It offers essential knowledge for those looking to explore the practical applications and future potential of CNDs. With its emphasis on sustainability and cutting-edge research, this volume invites readers to think critically about the role of CNDs in addressing global challenges in health, food, and agriculture.

This contributed volume explores the innovative applications and transformative potential of carbon nanodots (CNDs) in revolutionizing human health, food security, and agriculture. Edited by leading experts, it provides a comprehensive overview of the synthesis methods and unique properties that establish CNDs as a groundbreaking innovation in nanotechnology.The chapters cover a broad range of topics, including the role of CNDs in drug delivery, antimicrobial resistance, and cancer therapy. Readers will learn how CNDs are advancing diagnostics through bioimaging and biosensors, offering new pathways for early disease detection. The book also highlights their applications in sustainable agriculture, such as enhancing crop growth, protecting crops from pathogens, and improving food preservation techniques. Through a detailed examination of the latest scientific breakthroughs, it provides insights into the practical applications and future potential of CNDs. Additionally, it presents an analysis of the challenges and opportunities in scaling up CND production, addressing critical questions related to safety, toxicity, and regulatory frameworks.This book serves as an invaluable resource for researchers, industry professionals, and students in fields such as nanotechnology, materials science, and biotechnology. It offers essential knowledge for those looking to explore the practical applications and future potential of CNDs. With its emphasis on sustainability and cutting-edge research, this volume invites readers to think critically about the role of CNDs in addressing global challenges in health, food, and agriculture.

This book offers an in-depth analysis of enzyme-based approaches in healthcare management, focusing on their transformative potential in cancer treatment. This volume delves into the intricate roles of enzymes in cancer progression and targeted therapy.The book addresses a wide range of subjects, such as the functions of important enzymes in the biology of cancer, developments in targeting telomerase, the cell cycle, angiogenesis, and metastasis, and the possibility of using topoisomerase and PARP inhibitors to take advantage of weaknesses in cancer cells. It provides an in-depth analysis of non-glycolytic and glycolytic enzymes, tumor-driven angiogenesis, epigenetic regulation, and advanced therapeutic approaches, including nanotechnology and bispecific antibodies. It addresses key questions such as how enzymes contribute to cancer metabolism and how novel therapeutic strategies can exploit these pathways for more accurate and less dangerous cancer medicines. The book covers expert analyses of key enzymes involved in cancer biology, including hexokinase, phosphofructokinase-1, and matrix metalloproteinases.This book is an invaluable resource for researchers, clinicians, and professionals in the pharmaceutical and biotechnology industries. It offers a comprehensive overview of the molecular mechanisms underlying enzyme function in cancer and the development of innovative enzyme-targeted treatments. It is a must-read for those seeking to advance their understanding of enzyme-based healthcare management.