Lalit Kumar – författare

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and� their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems.

Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting.

Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and  their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems.Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting.- Provides information on the design and development of nanocarriers for targeting brain tumors- Outlines the working principles of different nanocarriers for targeting brain tumors- Includes case studies of different nanocarriers for targeting brain tumors

Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.Introduces different colonic diseases and their pathophysiologyExplains the mechanism of action of different nanocarriers in colon targetingPresents case studies of different nanocarriers in colon targeting

Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology''s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.- Introduces different colonic diseases and their pathophysiology- Explains the mechanism of action of different nanocarriers in colon targeting- Presents case studies of different nanocarriers in colon targeting

Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-?, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.Offers comprehensive insights into tissue-specific and tumor-specific molecular targets for cancer therapyExplores novel therapeutic strategies to enhance precision medicine in oncologyDiscusses the critical mediators that influence tumor immunity and therapeutic interventionsHighlights advanced approaches, including nanotechnology, for improved drug delivery systemsProvides practical applications for targeted therapies to optimize patient outcomes

Role of Biomarkers in Cancer Diagnosis and Therapeutics offers a thorough exploration of the critical roles biomarkers play in cancer detection, diagnosis, monitoring, and therapy. Sections focus on established and emerging biomarkers like PSA and CEA, detailing their biochemical characteristics and clinical relevance, and examining metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic potential. The final part pf the book discusses innovative strategies targeting cell cycle checkpoints and DNA repair mechanisms, including synthetic lethality through PARP inhibitors. This essential resource provides researchers and clinicians with insights into novel metabolic targets and cutting-edge treatment strategies.By addressing current applications and future challenges, including the integration of AI and multi-omics approaches, the book equips readers with actionable knowledge to advance personalized cancer care and navigate the dynamic landscape of oncology.Provides an in-depth analysis of both established and emerging cancer biomarkers, detailing their biochemical characteristics, clinical relevance, and diagnostic potential across various malignanciesExplores critical metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic implications, thereby offering insights into novel targets for cancer treatmentDiscusses cutting-edge approaches that target cell cycle checkpoints and DNA repair mechanisms, including the concept of synthetic lethality, thus equipping readers with advanced knowledge for personalized cancer therapies

Role of Biomarkers in Cancer Diagnosis and Therapeutics offers a thorough exploration of the critical roles biomarkers play in cancer detection, diagnosis, monitoring, and therapy. Sections focus on established and emerging biomarkers like PSA and CEA, detailing their biochemical characteristics and clinical relevance, and examining metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic potential. The final part pf the book discusses innovative strategies targeting cell cycle checkpoints and DNA repair mechanisms, including synthetic lethality through PARP inhibitors. This essential resource provides researchers and clinicians with insights into novel metabolic targets and cutting-edge treatment strategies.By addressing current applications and future challenges, including the integration of AI and multi-omics approaches, the book equips readers with actionable knowledge to advance personalized cancer care and navigate the dynamic landscape of oncology. - Provides an in-depth analysis of both established and emerging cancer biomarkers, detailing their biochemical characteristics, clinical relevance, and diagnostic potential across various malignancies- Explores critical metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic implications, thereby offering insights into novel targets for cancer treatment- Discusses cutting-edge approaches that target cell cycle checkpoints and DNA repair mechanisms, including the concept of synthetic lethality, thus equipping readers with advanced knowledge for personalized cancer therapies

This book reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.Key Features:Reviews the development of medicinal compounds from historical remedies to modern innovationsPresents the therapeutic potential of bioactive compounds from microorganisms and the crucial roles of antioxidants and anti-inflammatory agents in disease managementDescribes the innovations in drug delivery systems, epigenetic modifiers, and immunomodulatory agentsProvides guidance on regulatory considerations and intellectual property in medicinal compound developmentExamines the role of nanotechnology and the integration of traditional and modern therapiesThis book is intended for researchers of ethnopharmacology, pharmaceutical sciences, and medicinal chemistry.

This book reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.Key Features: Reviews the development of medicinal compounds from historical remedies to modern innovations Presents the therapeutic potential of bioactive compounds from microorganisms and the crucial roles of antioxidants and anti-inflammatory agents in disease management Describes the innovations in drug delivery systems, epigenetic modifiers, and immunomodulatory agents Provides guidance on regulatory considerations and intellectual property in medicinal compound development Examines the role of nanotechnology and the integration of traditional and modern therapies This book is intended for researchers of ethnopharmacology, pharmaceutical sciences, and medicinal chemistry.

This book reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.Key Features: Reviews the development of medicinal compounds from historical remedies to modern innovations Presents the therapeutic potential of bioactive compounds from microorganisms and the crucial roles of antioxidants and anti-inflammatory agents in disease management Describes the innovations in drug delivery systems, epigenetic modifiers, and immunomodulatory agents Provides guidance on regulatory considerations and intellectual property in medicinal compound development Examines the role of nanotechnology and the integration of traditional and modern therapies This book is intended for researchers of ethnopharmacology, pharmaceutical sciences, and medicinal chemistry.

This book reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental health care. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.Key Features:Reviews the development of medicinal compounds from historical remedies to modern innovationsPresents therapeutic potential of bioactive compounds from microorganisms and the crucial roles of antioxidants and anti-inflammatory agents in disease managementDescribes the innovations in drug delivery systems, epigenetic modifiers, and immunomodulatory agentsProvide guidance on regulatory considerations and intellectual property in medicinal compound developmentExamine the role of nanotechnology and the integration of traditional and modern therapiesThis book is intended for researchers of ethnopharmacology, pharmaceutical sciences, and medicinal chemistry.

Master GIS Applications on Modelling and Mapping the Risks of DiseasesInfections transmitted by mosquitoes, ticks, triatomine bugs, sandflies, and black flies cause significant rates of death and disease, especially in developing countries. Why are certain places more susceptible to vector-borne diseases? Modelling Interactions Between Vector-Borne Diseases and Environment Using GIS reveals how using geographic information systems (GISs) can provide a greater understanding of how vector-borne diseases are spread and explores the use of geographical techniques in vector-borne disease monitoring, management, and control. This text provides readers with a better understanding of the vector-borne disease problem and its impact on public health. Introduces New Spatial Approaches Based on Location and EnvironmentThe book exposes readers to information on how to identify vector hotspots, determine when and where they can occur, and eliminate vector breeding sites. Utilizing simple illustrations based on real data, as well as the authors’ more than 20 years of experience in the field, this text combines key spatial analysis techniques available in modern GIS with real-world applications. It offers step-by-step instruction on developing vector-borne disease risk models at different spatial and temporal scales and helps practitioners formulate disease causation hypotheses and identify areas at risk. In addition, it addresses medical geography, GIS, spatial analysis, and modelling, and covers other factors related to the spread of vector-borne diseases.This book: Gives an overview of common vector-borne diseases, GIS-based mapping and modelling, impacts of climate change on vector distributions, and availability and importance of accurate epidemiologically relevant spatial dataDescribes modelling and simulating the prevalence of vector-borne diseases around the worldSummarizes some key spatial techniques and how they can be used to aid in the analysis of geographical and attributed dataDefines the concept of establishing and characterizing spatial data systems, including their quality, errors, references, and issues of scale, and building such a system from often quite separate, disparate sourcesShows how to develop weather-based predictive modelling, which can be used to predict the weekly trend of vector abundanceProvides a GIS case study for modelling the future potential distribution of vector-borne disease based on different climatic change scenariosModelling Interactions Between Vector-Borne Diseases and Environment Using GIS combines spatial analysis techniques available in modern GIS, together with real-world applications to provide you with a better understanding of ways to map, model, prevent, and control vector-borne diseases.

Master GIS Applications on Modelling and Mapping the Risks of DiseasesInfections transmitted by mosquitoes, ticks, triatomine bugs, sandflies, and black flies cause significant rates of death and disease, especially in developing countries. Why are certain places more susceptible to vector-borne diseases? Modelling Interactions Between Vector-Borne Diseases and Environment Using GIS reveals how using geographic information systems (GISs) can provide a greater understanding of how vector-borne diseases are spread and explores the use of geographical techniques in vector-borne disease monitoring, management, and control. This text provides readers with a better understanding of the vector-borne disease problem and its impact on public health. Introduces New Spatial Approaches Based on Location and EnvironmentThe book exposes readers to information on how to identify vector hotspots, determine when and where they can occur, and eliminate vector breeding sites. Utilizing simple illustrations based on real data, as well as the authors’ more than 20 years of experience in the field, this text combines key spatial analysis techniques available in modern GIS with real-world applications. It offers step-by-step instruction on developing vector-borne disease risk models at different spatial and temporal scales and helps practitioners formulate disease causation hypotheses and identify areas at risk. In addition, it addresses medical geography, GIS, spatial analysis, and modelling, and covers other factors related to the spread of vector-borne diseases.This book: Gives an overview of common vector-borne diseases, GIS-based mapping and modelling, impacts of climate change on vector distributions, and availability and importance of accurate epidemiologically relevant spatial dataDescribes modelling and simulating the prevalence of vector-borne diseases around the worldSummarizes some key spatial techniques and how they can be used to aid in the analysis of geographical and attributed dataDefines the concept of establishing and characterizing spatial data systems, including their quality, errors, references, and issues of scale, and building such a system from often quite separate, disparate sourcesShows how to develop weather-based predictive modelling, which can be used to predict the weekly trend of vector abundanceProvides a GIS case study for modelling the future potential distribution of vector-borne disease based on different climatic change scenariosModelling Interactions Between Vector-Borne Diseases and Environment Using GIS combines spatial analysis techniques available in modern GIS, together with real-world applications to provide you with a better understanding of ways to map, model, prevent, and control vector-borne diseases.

This edited volume addresses the impacts of climate change on Pacific islands, and presents databases and indexes for assessing and adapting to island vulnerabilities. By analyzing susceptibility variables, developing comprehensive vulnerability indexes, and applying GIS techniques, the book's authors demonstrate the particular issues presented by climate change in the islands of the Pacific region, and how these issues may be managed to preserve and improve biodiversity and human livelihoods. The book first introduces the issues specific to island communities, such as high emissions impacts, and discusses the importance of the lithological traits of Pacific islands and how these physical factors relate to climate change impacts. From here, the book aims to analyze the various vulnerabilities of different island sectors, and to formulate a susceptibility index from these variables to be used by government and planning agencies for relief prioritization. Such variables include tropical cyclones, built infrastructures, proximity to coastal areas, agriculture, fisheries and marine resources, groundwater availability, biodiversity, and economic impacts on industries such as tourism. Through the categorization and indexing of these variables, human and physical adaptation measures are proposed, and support solutions are offered to aid the inhabitants of affected island countries. This book is intended for policy makers, academics, and climate change researchers, particularly those dealing with climate change impacts on small islands.

This edited volume addresses the impacts of climate change on Pacific islands, and presents databases and indexes for assessing and adapting to island vulnerabilities. By analyzing susceptibility variables, developing comprehensive vulnerability indexes, and applying GIS techniques, the book''s authors demonstrate the particular issues presented by climate change in the islands of the Pacific region, and how these issues may be managed to preserve and improve biodiversity and human livelihoods. 

The book first introduces the issues specific to island communities, such as high emissions impacts, and discusses the importance of the lithological traits of Pacific islands and how these physical factors relate to climate change impacts. From here, the book aims to analyze the various vulnerabilities of different island sectors, and to formulate a susceptibility index from these variables to be used by government and planning agencies for relief prioritization. Such variables include tropical cyclones, built infrastructures, proximity to coastal areas, agriculture, fisheries and marine resources, groundwater availability, biodiversity, and economic impacts on industries such as tourism. Through the categorization and indexing of these variables, human and physical adaptation measures are proposed, and support solutions are offered to aid the inhabitants of affected island countries. This book is intended for policy makers, academics, and climate change researchers, particularly those dealing with climate change impacts on small islands.

This edited volume addresses the impacts of climate change on Pacific islands, and presents databases and indexes for assessing and adapting to island vulnerabilities. By analyzing susceptibility variables, developing comprehensive vulnerability indexes, and applying GIS techniques, the book's authors demonstrate the particular issues presented by climate change in the islands of the Pacific region, and how these issues may be managed to preserve and improve biodiversity and human livelihoods. The book first introduces the issues specific to island communities, such as high emissions impacts, and discusses the importance of the lithological traits of Pacific islands and how these physical factors relate to climate change impacts. From here, the book aims to analyze the various vulnerabilities of different island sectors, and to formulate a susceptibility index from these variables to be used by government and planning agencies for relief prioritization. Such variables include tropical cyclones, built infrastructures, proximity to coastal areas, agriculture, fisheries and marine resources, groundwater availability, biodiversity, and economic impacts on industries such as tourism. Through the categorization and indexing of these variables, human and physical adaptation measures are proposed, and support solutions are offered to aid the inhabitants of affected island countries. This book is intended for policy makers, academics, and climate change researchers, particularly those dealing with climate change impacts on small islands.

This book offers an in-depth analysis of enzyme-based approaches in healthcare management, focusing on their transformative potential in cancer treatment. This volume delves into the intricate roles of enzymes in cancer progression and targeted therapy.The book addresses a wide range of subjects, such as the functions of important enzymes in the biology of cancer, developments in targeting telomerase, the cell cycle, angiogenesis, and metastasis, and the possibility of using topoisomerase and PARP inhibitors to take advantage of weaknesses in cancer cells. It provides an in-depth analysis of non-glycolytic and glycolytic enzymes, tumor-driven angiogenesis, epigenetic regulation, and advanced therapeutic approaches, including nanotechnology and bispecific antibodies. It addresses key questions such as how enzymes contribute to cancer metabolism and how novel therapeutic strategies can exploit these pathways for more accurate and less dangerous cancer medicines. The book covers expert analyses of key enzymes involved in cancer biology, including hexokinase, phosphofructokinase-1, and matrix metalloproteinases.This book is an invaluable resource for researchers, clinicians, and professionals in the pharmaceutical and biotechnology industries. It offers a comprehensive overview of the molecular mechanisms underlying enzyme function in cancer and the development of innovative enzyme-targeted treatments. It is a must-read for those seeking to advance their understanding of enzyme-based healthcare management.

This book offers an in-depth analysis of enzyme-based approaches in healthcare management, focusing on their transformative potential in cancer treatment. This volume delves into the intricate roles of enzymes in cancer progression and targeted therapy.The book addresses a wide range of subjects, such as the functions of important enzymes in the biology of cancer, developments in targeting telomerase, the cell cycle, angiogenesis, and metastasis, and the possibility of using topoisomerase and PARP inhibitors to take advantage of weaknesses in cancer cells. It provides an in-depth analysis of non-glycolytic and glycolytic enzymes, tumor-driven angiogenesis, epigenetic regulation, and advanced therapeutic approaches, including nanotechnology and bispecific antibodies. It addresses key questions such as how enzymes contribute to cancer metabolism and how novel therapeutic strategies can exploit these pathways for more accurate and less dangerous cancer medicines. The book covers expert analyses of key enzymes involved in cancer biology, including hexokinase, phosphofructokinase-1, and matrix metalloproteinases.This book is an invaluable resource for researchers, clinicians, and professionals in the pharmaceutical and biotechnology industries. It offers a comprehensive overview of the molecular mechanisms underlying enzyme function in cancer and the development of innovative enzyme-targeted treatments. It is a must-read for those seeking to advance their understanding of enzyme-based healthcare management.