Wolfgang Huber – författare

Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R.

This volume''s coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms:

Curation and delivery of biological metadata for use in statistical modeling and interpretation

Statistical analysis of high-throughput data, including machine learning and visualization

Modeling and visualization of graphs and networks

The developers of the software, who are in many cases leading academic researchers, jointly authored chapters. All methods are illustrated with publicly available data, and a major section of the book is devoted to exposition of fully worked case studies.

This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volume, the authors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include: (1) import and preprocessing of data from various sources; (2) statistical modeling of differential gene expression; (3) biological metadata; (4) application of graphs and graph rendering; (5) machine learning for clustering and classification problems; (6) gene set enrichment analysis.

Each chapter of this book describes an analysis of real data using hands-on example driven approaches. Short exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table.

In the twenty-first century the basic questions of ethics are no longer the abstract terms of ethical theory, but the concrete and burning issues related to the influence of life sciences, the impact of a globalized economy, and the consequences of present decisions for the future of humankind. Ethics: The Fundamental Questions of Our Lives analyzes twenty ethical issues that address education and culture, labor and economy, the environment and sustainability, democracy and cosmopolitanism, peace and war, and life and death. Each chapter describes a concrete example showing the relevance of the fundamental ethical question, then provides an explanation of how one can think through possible responses and reactions. Huber emphasizes the connections between personal, professional, and institutional ethics and demonstrates how human relationships lie at the center of our ethical lives. His aim is to articulate a theology of what he calls "responsible freedom" that transcends individualistic self-realization and includes communal obligations.