Wolfgang Huber - Böcker

Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R. This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms:Curation and delivery of biological metadata for use in statistical modeling and interpretationStatistical analysis of high-throughput data, including machine learning and visualizationModeling and visualization of graphs and networksThe developers of the software, who are in many cases leading academic researchers, jointly authored chapters. All methods are illustrated with publicly available data, and a major section of the book is devoted to exposition of fully worked case studies. This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document.Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volume, the authors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include: (1) import and preprocessing of data from various sources; (2) statistical modeling of differential gene expression; (3) biological metadata; (4) application of graphs and graph rendering; (5) machine learning for clustering and classification problems; (6) gene set enrichment analysis.Each chapter of this book describes an analysis of real data using hands-on example driven approaches. Short exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table.

If you are a biologist and want to get the best out of the powerful methods of modern computational statistics, this is your book. You can visualize and analyze your own data, apply unsupervised and supervised learning, integrate datasets, apply hypothesis testing, and make publication-quality figures using the power of R/Bioconductor and ggplot2. This book will teach you 'cooking from scratch', from raw data to beautiful illuminating output, as you learn to write your own scripts in the R language and to use advanced statistics packages from CRAN and Bioconductor. It covers a broad range of basic and advanced topics important in the analysis of high-throughput biological data, including principal component analysis and multidimensional scaling, clustering, multiple testing, unsupervised and supervised learning, resampling, the pitfalls of experimental design, and power simulations using Monte Carlo, and it even reaches networks, trees, spatial statistics, image data, and microbial ecology. Using a minimum of mathematical notation, it builds understanding from well-chosen examples, simulation, visualization, and above all hands-on interaction with data and code.

In the twenty-first century the basic questions of ethics are no longer the abstract terms of ethical theory, but the concrete and burning issues related to the influence of life sciences, the impact of a globalized economy, and the consequences of present decisions for the future of humankind. Ethics: The Fundamental Questions of Our Lives analyzes twenty ethical issues that address education and culture, labor and economy, the environment and sustainability, democracy and cosmopolitanism, peace and war, and life and death. Each chapter describes a concrete example showing the relevance of the fundamental ethical question, then provides an explanation of how one can think through possible responses and reactions. Huber emphasizes the connections between personal, professional, and institutional ethics and demonstrates how human relationships lie at the center of our ethical lives. His aim is to articulate a theology of what he calls "responsible freedom" that transcends individualistic self-realization and includes communal obligations.

In the twenty-first century the basic questions of ethics are no longer the abstract terms of ethical theory, but the concrete and burning issues related to the influence of life sciences, the impact of a globalized economy, and the consequences of present decisions for the future of humankind. Ethics: The Fundamental Questions of Our Lives analyzes twenty ethical issues that address education and culture, labor and economy, the environment and sustainability, democracy and cosmopolitanism, peace and war, and life and death. Each chapter describes a concrete example showing the relevance of the fundamental ethical question, then provides an explanation of how one can think through possible responses and reactions. Huber emphasizes the connections between personal, professional, and institutional ethics and demonstrates how human relationships lie at the center of our ethical lives. His aim is to articulate a theology of what he calls "responsible freedom" that transcends individualistic self-realization and includes communal obligations.

Wolfgang Huber, der am 12. August 2022 seinen achtzigsten Geburtstag feiert, hat den Protestantismus in der Bundesrepublik Deutschland in unterschiedlichen Funktionen geprägt. Als Professor für Systematische Theologie in Marburg und Heidelberg von 1980 bis 1994 trieb er die Etablierung der Ethik als einer eigenständig profilierten theologischen Disziplin insbesondere angesichts der zeitgenössischen friedensethischen und bioethischen Herausforderungen mit voran. Als Präsident des Deutschen Evangelischen Kirchentages von 1983 bis 1985 engagierte er sich mit Nachdruck dafür, den politischen Charakter des Kirchentages als Konsequenz aus dessen religiöser Verankerung deutlich zu machen. Als Bischof der Evangelischen Kirche Berlin-Brandenburg-schlesische Oberlausitz von 1993 bis 2009 moderierte er das Zusammenwachsen westlicher und östlicher Teile der Evangelischen Kirche an zentraler Stelle. Als Vorsitzender des Rates der EKD von 2003 bis 2009 nutzte er die ihm damit zur Verfügung stehenden Möglichkeiten, auf der politischen Ebene praktisch einzustehen für seine theologischen Überzeugungen. Und als theologischer Schriftsteller hat er nicht nur die fachwissenschaftlichen Debatten vorangetrieben, sondern mit vielen Veröffentlichungen auch dafür gesorgt, dass Einstellungen und Einsichten des evangelischen Christentums einem breiteren interessierten Publikum verständlich und vertraut werden konnten.In diesem Gesprächsband lässt Wolfgang Huber im Dialog mit den Münchener Theologen Christian Albrecht und Reiner Anselm sowie dem Göttinger Staatsrechtslehrer Hans Michael Heinig wissenschaftsbiographische und kirchenpolitische Etappen Revue passieren.