Handbook of Chemical Biology of Nucleic Acids

Naoki Sugimoto received Ph.D. degree in 1985 from Kyoto University, Japan. After postdoctoral work at University of Rochester, USA, he joined Konan University, Kobe, Japan in 1988 and is a full professor since 1994. From 2003, he also holds a director of Frontier Institute for Biomolecular Engineering Research (FIBER) at Konan University. He is a member of the Editorial Board of Nucleic Acids Research from 2007 and Scientific Reports from 2015 to the present, was the first President of the Japan Society of Nucleic Acids Chemistry (JSNAC) from 2017 to 2020 and is now the Fellow of JSNAC. He received the Dr. Masao Horiba’s Award in 2004, Distinguished Scientist Award from ICA (International Copper Association), USA in 2005, Hyogo Science Award from Hyogo prefecture, Japan in 2006, the Chemical Society Japan (CSJ) Award for Creative Work in 2007, JSCC Contribution Award, Japan Society of Coordination Chemistry (JSCC) in 2014, The Iue Cultural Award in Scienceand Technology in 2015, The Imbach-Townsend Award, IS3NA in 2018, The 72th CSJ Award (Top Award in CSJ) in 2019, and so on. His research interests focus on biophysical chemistry, biomaterials, bionano-engineering, molecular design, biofunctional chemistry, biotechnology, and therapeutic application of nucleic acids.

• High-Pressure Single-Molecule Studies on Non-canonical Nucleic Acids and Their Interactions.- Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids.- The Effect of Pressure on the Conformational Stability of DNA.- Quadruplexes are everywhere…on the other strand too: the i-motif.- i-Motif Nucleic Acids.- NMR Study on Nucleic Acids.- Z-DNA.- Structures of DNA G-quadruplexes and Their Drug Interactions.- In cell 19F NMR for G-quadruplex.- Structures and Catalytic Activities of Complexes between Heme and DNA.- Studying nucleic acid-ligand binding by X-ray crystallography.- Predicting the 3D structure of RNA from sequence.- XNA in Synthetic Biology.- The Effects of FANA Modifications on Non-Canonical Nucleic Acid Structures.- Isomorphic Fluorescent Nucleoside Analogs.- Bridged Nucleic Acids for Therapeutic Oligonucleotides.- Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents.- Chemistry of Cyclic Dinucleotides and Analogs.- Labeling and Detection of Modified Nucleic Acids.- Cross linking Duplex of Nucleic Acids with Modified Oligonucleotides.- Enzymatic Synthesis of Base-Modified Nucleic Acids.- Charge Transfer in Natural and Artificial Nucleic Acids.- Nucleic Acid Aptamers: From Basic Research to Clinical Applications.- LNA in Medical Biology.- Targeting Quadruplex Nucleic Acids: The Bisquinolinium Saga.- Compound Shape and Substituent Effects in DNA Minor Groove Interactions.- Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs.- Cyclic Naphthalene Diimide Derivatives as Novel DNA Ligands.- Imaging study of small molecules to G-quadruplexes in cells.- Bivalent Nucleic Acid Ligands.- DNA/Metal Cluster–Based Nano-Lantern.- Interaction of Poly (ethylene glycol)-b-poly-L-lysine Copolymers with DNA Structures: A Thermodynamic Investigation.- Chemical tools to target non-coding RNAs.- Targeting DNA junctions with small molecules for therapeutic applications in oncology.- DNA Damage and Repair in G-quadruplexesImpact Gene Expression.- DNA Structural Elements as Potential Targets for Regulation of Gene Expression.- Effects of molecular crowding on structures and functions of nucleic acids.- Structure-guided Optimization of siRNA and anti-miRNA Properties.- Tools for understanding the chemical biology of the tRNA epitranscriptome.- Sulfur and Selenium modified bacterial tRNAs.- Chemical-assisted Epigenome Sequencing.- Epitranscriptomics. Telomeres and Telomerase.- Genetic Alphabet Expansion of Nucleic Acids.- Unnatural Base Pairs to Expand the Genetic Alphabet and Code.- OGG1 at the crossroads between repair and transcriptional regulation.- Phosphorothioate Nucleic Acids - Artificial Modification Envisaged by Nature.- Aptamer Molecular Evolution for Liquid Biopsy.- Functions and Applications of Riboswitches.- PNA and Quadruplex.- Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies.- Structure and Function of Aptamer and Catalytic DNA.- Origin and Evolution of RNA.- Targeting RNA with Small Molecules.