Biologically-Inspired Systems – serie

The extracellular matrix (ECM) is an acellular three-dimensional network composed of proteins, glycoproteins, proteoglycans and exopolysaccharides. It primarily serves as a structural component in the tissues and organs of plants and animals, or forms biofilms in which bacterial cells are embedded. ECMs are highly dynamic structures that undergo continuous remodeling, and disruptions are frequently the result of pathological processes associated with severe diseases such as arteriosclerosis, neurodegenerative illness or cancer. In turn, bacterial biofilms are a source of concern for human health, as they are associated with resistance to antibiotics. Although exopolysaccharides are crucial for ECM formation and function, they have received considerably little attention to date.The respective chapters of this book comprehensively address such issues, and provide reviews on the structural, biochemical, molecular and biophysical properties of exopolysaccharides. These components are abundantly produced by virtually all taxa including bacteria, algae, plants, fungi, invertebrates and vertebrates. They include long unbranched homopolymers (cellulose, chitin/chitosan), linear copolymers (alginate, agarose), peptoglycans such as murein, heteropolymers like a variety of glycosaminoglycans (hyaluronan, dermatan, keratin, heparin, Pel), and branched heteropolymers such as pectin and hemicellulose.A separate chapter is dedicated to modern industrial and biomedical applications of exopolysaccharides and polysaccharide-based biocomposites. Their unique chemical, physical and mechanical properties have attracted considerable interest, inspired basic and applied research, and have already been harnessed to form structural biocomposite hybrids for tailor-made applications in regenerative medicine, bioengineering and biosensor design. Given its scope, this book provides a substantial source of basic and applied information for a wide range of scientists, as well as valuable textbook for graduate and advanced undergraduate students.

The extracellular matrix (ECM) is an acellular three-dimensional network composed of proteins, glycoproteins, proteoglycans and exopolysaccharides. It primarily serves as a structural component in the tissues and organs of plants and animals, or forms biofilms in which bacterial cells are embedded. ECMs are highly dynamic structures that undergo continuous remodeling, and disruptions are frequently the result of pathological processes associated with severe diseases such as arteriosclerosis, neurodegenerative illness or cancer. In turn, bacterial biofilms are a source of concern for human health, as they are associated with resistance to antibiotics. Although exopolysaccharides are crucial for ECM formation and function, they have received considerably little attention to date.The respective chapters of this book comprehensively address such issues, and provide reviews on the structural, biochemical, molecular and biophysical properties of exopolysaccharides. These components are abundantly produced by virtually all taxa including bacteria, algae, plants, fungi, invertebrates and vertebrates. They include long unbranched homopolymers (cellulose, chitin/chitosan), linear copolymers (alginate, agarose), peptoglycans such as murein, heteropolymers like a variety of glycosaminoglycans (hyaluronan, dermatan, keratin, heparin, Pel), and branched heteropolymers such as pectin and hemicellulose.A separate chapter is dedicated to modern industrial and biomedical applications of exopolysaccharides and polysaccharide-based biocomposites. Their unique chemical, physical and mechanical properties have attracted considerable interest, inspired basic and applied research, and have already been harnessed to form structural biocomposite hybrids for tailor-made applications in regenerative medicine, bioengineering and biosensor design. Given its scope, this book provides a substantial source of basic and applied information for a wide range of scientists, as well as valuable textbook for graduate and advanced undergraduate students.

In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system?

In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system?

The contributed volume puts emphasis on a superior role of water in (bio)systems exposed to a mechanical stimulus. It is well known that water plays an extraordinary role in our life. It feeds mammalian or other organism after distributing over its whole volume to support certain physiological and locomotive (friction-adhesion) processes to mention but two of them, both of extreme relevance.Water content, not only in the mammalian organism but also in other biosystems such as whether those of soil which is equipped with microbiome or the ones pertinent to plants, having their own natural network of water vessels, is always subjected to a force field.The decisive force field applied to the biosystems makes them biomechanically agitated irrespective of whether they are subjected to external or internal force-field conditions. It ought to be noted that the decisive mechanical factor shows up in a close relation with the space-and-time scale in which it is causing certain specific phenomena to occur.The scale problem, emphasizing the range of action of gravitational force, thus the millimeter or bigger force vs. distance scale, is supposed to enter the so-called macroscale approach to water transportation through soil or plants’ roots system. It is merely related to a percolation problem, which assumes to properly inspect the random network architecture assigned to the biosystems invoked. The capillarity conditions turn out to be of prior importance, and the porous-medium effect has to be treated, and solved in a fairly approximate way.The deeper the scale is penetrated by a force-exerting and hydrated agent the more non-gravitational force fields manifest. This can be envisaged in terms of the corresponding thermodynamic (non-Newtonian) forces, and the phenomena of interest are mostly attributed to suitable changes of the osmotic pressure. In low Reynolds number conditions, thus inthe (sub)micrometer distance-scale zone, they are related with the corresponding viscosity changes of the aqueous, e.g. cytoplasmatic solutions, of semi-diluted and concentrated (but also electrolytic) characteristics. For example, they can be observed in articulating systems of mammals, in their skin, and to some extent, in other living beings, such as lizards, geckos or even insects. Through their articulating devices an external mechanical stimulus is transmitted from macro- to nanoscale, wherein the corresponding osmotic-pressure conditions apply.The content of the proposed work can be distributed twofold. First, the biomechanical mammalian-type (or, similar) systems with extraordinary relevance of water for their functioning will be presented, also including a presentation of water itself as a key physicochemical system/medium. Second, the suitably chosen related systems, mainly of soil and plant addressing provenience, will be examined thoroughly. As a common denominator of all of them, it is proposed to look at their hydrophobic and/or (de)hydration effects, and how do they impact on their basic mechanical (and related, such as chemo-mechanical or piezoelectric, etc.) properties. An additional tacit assumption employed throughout the monograph concerns statistical scalability of the presented biosystems which is equivalent to take for granted a certain similarity between local and global system’s properties, mostly those of mechanical nature. The presented work’s chapters also focus on biodiversity and ecological aspects in the world of animals and plants, and the related systems. The chapters’ contents underscore the bioinspiration as the key landmark of the proposed monograph.

The contributed volume puts emphasis on a superior role of water in (bio)systems exposed to a mechanical stimulus. It is well known that water plays an extraordinary role in our life. It feeds mammalian or other organism after distributing over its whole volume to support certain physiological and locomotive (friction-adhesion) processes to mention but two of them, both of extreme relevance.Water content, not only in the mammalian organism but also in other biosystems such as whether those of soil which is equipped with microbiome or the ones pertinent to plants, having their own natural network of water vessels, is always subjected to a force field.The decisive force field applied to the biosystems makes them biomechanically agitated irrespective of whether they are subjected to external or internal force-field conditions. It ought to be noted that the decisive mechanical factor shows up in a close relation with the space-and-time scale in which it is causing certain specific phenomena to occur.The scale problem, emphasizing the range of action of gravitational force, thus the millimeter or bigger force vs. distance scale, is supposed to enter the so-called macroscale approach to water transportation through soil or plants’ roots system. It is merely related to a percolation problem, which assumes to properly inspect the random network architecture assigned to the biosystems invoked. The capillarity conditions turn out to be of prior importance, and the porous-medium effect has to be treated, and solved in a fairly approximate way.The deeper the scale is penetrated by a force-exerting and hydrated agent the more non-gravitational force fields manifest. This can be envisaged in terms of the corresponding thermodynamic (non-Newtonian) forces, and the phenomena of interest are mostly attributed to suitable changes of the osmotic pressure. In low Reynolds number conditions, thus inthe (sub)micrometer distance-scale zone, they are related with the corresponding viscosity changes of the aqueous, e.g. cytoplasmatic solutions, of semi-diluted and concentrated (but also electrolytic) characteristics. For example, they can be observed in articulating systems of mammals, in their skin, and to some extent, in other living beings, such as lizards, geckos or even insects. Through their articulating devices an external mechanical stimulus is transmitted from macro- to nanoscale, wherein the corresponding osmotic-pressure conditions apply.The content of the proposed work can be distributed twofold. First, the biomechanical mammalian-type (or, similar) systems with extraordinary relevance of water for their functioning will be presented, also including a presentation of water itself as a key physicochemical system/medium. Second, the suitably chosen related systems, mainly of soil and plant addressing provenience, will be examined thoroughly. As a common denominator of all of them, it is proposed to look at their hydrophobic and/or (de)hydration effects, and how do they impact on their basic mechanical (and related, such as chemo-mechanical or piezoelectric, etc.) properties. An additional tacit assumption employed throughout the monograph concerns statistical scalability of the presented biosystems which is equivalent to take for granted a certain similarity between local and global system’s properties, mostly those of mechanical nature. The presented work’s chapters also focus on biodiversity and ecological aspects in the world of animals and plants, and the related systems. The chapters’ contents underscore the bioinspiration as the key landmark of the proposed monograph.

This book contains contributions from leading researchers in biomechanics, nanomechanics, tribology, contact mechanics, materials science and applications on various experimental techniques including atomic force microscopy (AFM) for studying soft, biomimetic and biological materials and objects.

This book contains contributions from leading researchers in biomechanics, nanomechanics, tribology, contact mechanics, materials science and applications on various experimental techniques including atomic force microscopy (AFM) for studying soft, biomimetic and biological materials and objects.

This book showcases the diverse strategies used by invertebrate organisms to enhance their structures with metals.

This book showcases the diverse strategies used by invertebrate organisms to enhance their structures with metals. Written by the leading scientists in this multidisciplinary field, this book explores a range of metal-enhanced structures that span the world of invertebrates, their wonderous uses, and their applications to human-engineered products. The articles, accompanied by artistic imagery, reveal how metals augment the cuticle of insect mouthparts, the tongue of snails, the slime of slugs, and the claws of crabs. Intended for evolutionary biologists, material scientists, and anybody with an interest in invertebrate biology, this book covers what we currently understand about the adaptive value of metals in structures and lays a foundation for future studies.

The book unlocks the future of metabolic research with our comprehensive resource, designed for scientists, clinicians, and industry professionals. This expertly curated collection delves into cutting-edge advancements in metabolic pathways, disease mechanisms, and innovative therapeutic strategies. Covering everything from fundamental biochemistry to translational medicine, our content bridges the gap between research and clinical application. Whether you're exploring metabolic disorders, precision medicine, or novel biomarkers, this resource provides in-depth insights backed by the latest scientific discoveries. Elevate your expertise and stay ahead in the dynamic field of metabolic sciences—your essential guide to ground breaking innovations awaits.

Biomimetics, Bionics, Bioinspiration, Biomimetics, and Biomimicry are terms describing the branch of science between the studies of nature’s solutions and their inspiration on engineering sciences and technologies. Bioinspiration is viewed as using almost all biological phenomena to stimulate research in non-biological sciences and technologies for modifying and improving human life and welfare. Within the last three decades, these topics are covered by a large number of publications (journals, books). These scientific topics are developed through a myriad of studies that cover different biomimetics fields ranging from structures, materials, behavior, and performances, to architecture and management. These topics undoubtedly play a major role in our attempts to establish sustainable development. Many books either present a compilation of examples or treat one specific topic. Our book provides an integrative functional approach linking biological questions and the engineering applications supported by numerous studies at various levels, from a large diversity of organisms (and their components) to diverse responses to the constraints of terrestrial and aquatic ecosystems. This book makes a significant contribution to some of the questions related to functional studies associated with bioinspiration. In this book, we decided to build a consortium of editors involved in the two main disciplines that play essential roles in our holistic approach of bioinspiration and must be integrated to optimize the bioinspired solutions: biology and physics. The main objective of the volume is to summarize the field of research from a large number of key examples, and to integrate functional studies with the bio-inspired technologies. It is increasingly clear that we must develop an integrative approach—one that brings together biologists’ understanding of how and why organisms function with the guiding principles that drive progress in the engineering sciences.

This book surveys attachment structures and adhesive secretions occurring in this class of animals and discusses the relationships between structure, properties, and function in the context of evolutionary trends, and biomimetic potential.

These advances in computational methods have opened a new era in biomimetics: local differentiation at various scales, the main feature of natural constructions, can for the first time not only be analysed, but to a certain extent also be transferred to building construction.

This book deals with the adhesion, friction and contact mechanics of living organisms. Further, it presents the remarkable adhesive abilities of the living organisms which inspired the design of novel micro- and nanostructured adhesives that can be used in various applications, such as climbing robots, reusable tapes, and biomedical bandages. The technologies for both the synthesis and construction of bio-inspired adhesive micro- and nanostructures, as well as their performance, are discussed in detail.Representatives of several animal groups, such as insects, spiders, tree frogs, and lizards, are able to walk on (and therefore attach to) tilted, vertical surfaces, and even ceilings in different environments. Studies have demonstrated that their highly specialized micro- and nanostructures, in combination with particular surface chemistries, are responsible for this impressive and reversible adhesion. These structures can maximize the formation of large effective contact areason surfaces of varying roughness and chemical composition under different environmental conditions.

This book is devoted to the rapidly growing area of science dealing with structure and properties of biological surfaces in their relation to particular functions. This volume, written by a team of specialists from different disciplines, covers various biological surface functions: sensing, coloration, attachment, drag reduction, moisture harvesting, etc. Because biological surfaces have a virtually endless potential of technological ideas for the development of new materials and systems, inspirations from biology could also be interesting for a broad range of topics in surface engineering. This volume together with two previous volumes “Functional Surfaces in Biology” (vols. 1 & 2 published in 2009) taken together, present a good reference for a novice in the field. The book is intended for use by researchers who are active, or intend to become active, in the field. The appeal of this topic is expected to be broad, ranging from classical biology, biomechanics and physics to such applied fields as materials science and surface engineering.

This book surveys attachment structures and adhesive secretions occurring in this class of animals and discusses the relationships between structure, properties, and function in the context of evolutionary trends, and biomimetic potential.

These advances in computational methods have opened a new era in biomimetics: local differentiation at various scales, the main feature of natural constructions, can for the first time not only be analysed, but to a certain extent also be transferred to building construction.

This book deals with the adhesion, friction and contact mechanics of living organisms. Further, it presents the remarkable adhesive abilities of the living organisms which inspired the design of novel micro- and nanostructured adhesives that can be used in various applications, such as climbing robots, reusable tapes, and biomedical bandages. The technologies for both the synthesis and construction of bio-inspired adhesive micro- and nanostructures, as well as their performance, are discussed in detail.Representatives of several animal groups, such as insects, spiders, tree frogs, and lizards, are able to walk on (and therefore attach to) tilted, vertical surfaces, and even ceilings in different environments. Studies have demonstrated that their highly specialized micro- and nanostructures, in combination with particular surface chemistries, are responsible for this impressive and reversible adhesion. These structures can maximize the formation of large effective contact areason surfaces of varying roughness and chemical composition under different environmental conditions.

The work is a source of modern knowledge on biomineralization, biomimetics and bioinspired materials science with respect to marine invertebrates. The author gives the most coherent analysis of the nature, origin and evolution of biocomposites and biopolymers isolated from and observed in the broad diversity of marine invertebrate organisms and within their unusual structural formations. The basic format is that of a major review article, with liberal use of references to original literature. There is a wealth of new and newly synthesized information, including dozens of previously unpublished images of unique marine creatures and structures from nano- to microscale including high-resolution scanning and transmission electron micrographs. The material is organized effectively along both biological (phyla) and functional lines. The classification of biological materials of marine origin is proposed and discussed. Much of the pertinent data is organized into tables, and extensive useis made of electron micrographs and line drawings. Several modern topics e.g. “biomineralization- demineralization-remineralization phenomena”, or “phenomenon of multiphase biomineralization”, are discussed in details. Traditionally, such current concepts as hierarchical organization of biocomposites and skeletal structures, structural bioscaffolds, biosculpturing, biomimetism and bioinspiration as tools for the design of innovative materials  are critically analyzed from both biological and materials science point of view using numerous unique examples of marine origin. This monograph reviews the most relevant advances in the marine biomaterials research field, pointing out several approaches being introduced and explored by distinct laboratories.

Superhydrophobic surfaces, artificially mimicking lotus leaves, have captured the attention of scientists and engineers over the past few decades. Recent trends have shifted from superhydrophobicity to superominipohobicity, or superamphiphobicity. In addition, dynamic rather than static surface wetting/dewetting properties, which can be triggered by various stimuli, including temperature, pH, magnetic/electric fields, solvents, light exposure etc, have been highly sought after for commercial applications. This book will focus on recent topics related to various stimuli-responsive wetting/dewetting surfaces, and give an overview of the knowledge and concepts of how to design and establish these smart artificial surfaces, which can be used for technical developments in a wide variety research fields.

The book provides a fascinating overview about current and sophisticated developments in applied entomology that are powered by molecular biology and that can be summarized under a novel term: insect biotechnology. By analogy with the application of powerful molecular biological tools in medicine (red biotechnology), plant protection (green biotechnology) and industrial processing (white biotechnology), insect biotechnology (yellow biotechnology) provides novel tools and strategies for human welfare and nutrition. Insect Biotechnology has emerged as a prospering discipline with considerable economic potential, and encompasses the use of insect model organisms and insect-derived molecules in medical research as well as in modern plant protection measures.

This book is a collection of experimental studies demonstrating structure-function relationships in various biological systems having particular surface specialization to increase/decrease friction and adhesion. Studies on snake skin, adhesive pads, wing-interlocking devices and sticky mouthparts of insects as well as anti-adhesive and adhesive surfaces of plants are included in the volume containing four main subsections: (1) adhesion, (2) friction, (3) attachment-devices, (4) attachment-related behavior. Numerous experimental methods for characterizing tribological properties of biological surfaces at macro-, micro-, and nanoscale levels are demonstrated. This book is an excellent collection of publications on biotribology for both engineers and physicists working with biological systems as well as for biologists studying friction and adhesion. Inspirations from biology reported here may be also potentially interesting for biomimetics.

The book provides a fascinating overview about current and sophisticated developments in applied entomology that are powered by molecular biology and that can be summarized under a novel term: insect biotechnology. By analogy with the application of powerful molecular biological tools in medicine (red biotechnology), plant protection (green biotechnology) and industrial processing (white biotechnology), insect biotechnology (yellow biotechnology) provides novel tools and strategies for human welfare and nutrition. Insect Biotechnology has emerged as a prospering discipline with considerable economic potential, and encompasses the use of insect model organisms and insect-derived molecules in medical research as well as in modern plant protection measures.

This is the second monograph by the author on biological materials of marine origin. The initial book is dedicated to the biological materials of marine invertebrates. This work is a source of modern knowledge on biomineralization, biomimetics and materials science with respect to marine vertebrates. For the first time in scientific literature the author gives the most coherent analysis of the nature, origin and evolution of biocomposites and biopolymers isolated from and observed in the broad variety of marine vertebrate organisms (fish, reptilian, birds and mammals) and within their unique hierarchically organized structural formations. There is a wealth of new and newly synthesized information, including dozens of previously unpublished images of unique marine creatures including extinct, extant and living taxa and their biocomposite-based structures from nano- to micro – and macroscale. This monograph reviews the most relevant advances in the marine biological materials research field, pointing out several approaches being introduced and explored by distinct modern laboratories.

The application of silk to biomaterials is now very active on the basis of excellent properties of silks including recombinant silks for biomaterials and the accumulated structural information.

This book is a collection of experimental studies demonstrating structure-function relationships in various biological systems having particular surface specialization to increase/decrease friction and adhesion.

This volume contains studies on the evolution and function of lightweight constructions of planktonic and other organisms, and examples of how they can be used to create new solutions for radical innovations of lightweight constructions for technological application. The principles and underlying processes responsible for evolution and biodiversity of marine plankton organisms are highly relevant and largely unresolved issues in the field of marine science. Amongst the most promising objects for the study of evolution of stable lightweight constructions are marine organisms such as diatoms or radiolarians. Research in these fields requires interdisciplinary expertises such as in evolutionary modelling, paleontology, lightweight optimization, functional morphology, and marine ecology. Considerable effort and expert knowledge in production engineering or lightweight optimization is necessary to transfer knowledge on biogenic structures and evolutionary principles into new lightweight solutions. This book show methods and examples of how this can be achieved efficiently.

This is the second monograph by the author on biological materials of marine origin. The initial book is dedicated to the biological materials of marine invertebrates. This work is a source of modern knowledge on biomineralization, biomimetics and materials science with respect to marine vertebrates. For the first time in scientific literature the author gives the most coherent analysis of the nature, origin and evolution of biocomposites and biopolymers isolated from and observed in the broad variety of marine vertebrate organisms (fish, reptilian, birds and mammals) and within their unique hierarchically organized structural formations. There is a wealth of new and newly synthesized information, including dozens of previously unpublished images of unique marine creatures including extinct, extant and living taxa and their biocomposite-based structures from nano- to micro – and macroscale. This monograph reviews the most relevant advances in the marine biological materials research field, pointing out several approaches being introduced and explored by distinct modern laboratories.