Chemical Biology – serie
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27 produkter
Chemical Biology of Glycoproteins
Inbunden, 2017
3351 kr
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Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, …
High Throughput Screening Methods
Evolution and Refinement
Av Joshua A Bittker, Nathan T Ross
Inbunden, 2016
2705 kr
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High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current …
Mass Spectrometry in Chemical Biology
Evolving Applications
Av Norberto Peporine Lopes, Ricardo Roberto da Silva
Inbunden, 2017
2866 kr
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Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core …
Cyclic Peptides
From Bioorganic Synthesis to Applications
Av Jesko Koehnke, James Naismith m. fl.
Inbunden, 2017
3078 kr
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Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules. This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic …
Computational Tools for Chemical Biology
Inbunden, 2017
3260 kr
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The rapid development of efficient computational tools has allowed researchers to tackle biological problems and to predict, analyse and monitor, at an atomic level, molecular recognition processes. This book offers a fresh perspective on how computational tools can aid the chemical biology …
Protein Crystallography
Challenges and Practical Solutions
Av Konstantinos Beis, Gwyndaf Evans
Inbunden, 2018
2897 kr
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Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With …
Chemical and Biological Synthesis
Enabling Approaches for Understanding Biology
Av Nick J Westwood, Adam Nelson
Inbunden, 2018
3078 kr
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Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be …
Oxidative Folding of Proteins
Basic Principles, Cellular Regulation and Engineering
Inbunden, 2018
3260 kr
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The formation of disulphide bonds is probably the most influential modification of proteins. These bonds are unique among post-translational modifications of proteins as they can covalently link cysteine residues far apart in the primary sequence of a protein. This has the potential to convey …
DNA-targeting Molecules as Therapeutic Agents
Inbunden, 2018
2897 kr
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There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, …
Synthetic Glycomes
Av Wanyi Guan, Lei Li m. fl.
Inbunden, 2019
3078 kr
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Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in …
RNA Polymerases as Molecular Motors
On the Road
Av Robert Landick, Terence Strick m. fl.
Inbunden, 2021
2897 kr
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To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers …
Inhibitors of Protein–Protein Interactions
Small Molecules, Peptides and Macrocycles
Inbunden, 2020
2835 kr
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Protein–protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are …
Discovery and Utility of Chemical Probes in Target Discovery
Av Paul Brennan, Saleta Vazquez Rodriguez
Inbunden, 2020
2897 kr
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Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in …
Prebiotic Chemistry and Life's Origin
Inbunden, 2022
3078 kr
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How life originated from the inanimate mixture of organic and inorganic compounds on the priomordial earth remains one of the great unknowns in science. This origin of life, or abiogenesis, continues to be examined in the context of the conditions and materials required for natural life to have …
DNA Damage, DNA Repair and Disease
Volume 1
Av Miral Dizdaroglu, R Stephen Lloyd
Inbunden, 2020
3078 kr
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The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and …
Chemical Signatures of the Brain
Bridging Biochemistry, Neuroanatomy and Brain Disorders
Av Sachchida Nand Rai, Abhishek Kumar Singh
Inbunden, 2026
3096 kr
Kommande
Chemical Signatures of the Brain bridges biochemistry, neuroanatomy, and neuroscience to illuminate the molecular foundations of brain disorders. This interdisciplinary volume explores neurotransmitter systems, neuropeptides, lipid signalling, and energy metabolism, offering insights into the …
Imaging Tools for Chemical Biology
Av Lei Feng, Tony D James
Inbunden, 2024
3622 kr
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This book provides a comprehensive overview of multimodal and combined techniques used for imaging applications in Chemical Biology, including afterglow luminescence imaging, chemiluminescence imaging, delayed fluorescence imaging, AIE fluorescence imaging, and many more techniques. As well as …
Chemoenzymatic Synthesis of Natural Products and Complex Small Molecules
Av Frank Hahn
Inbunden, 2026
3709 kr
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The total synthesis of structurally complex natural products has challenged and inspired generations of chemists. However, despite their history as privileged bioactivity-rich scaffolds, the use of natural products in drug discovery has waned.Recent developments in biocatalysis have resulted in the …
Chemical Biology of Sulfur
Inbunden, 2020
3157 kr
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This volume aims to provide an in-depth view of the complete biochemistry of sulfur with an emphasis on aspects not covered elsewhere. Given its role in the formation of proteins and presence in the amino acids methionine and cysteine, sulfur is essential to life. Current literature on the …
Chronobiology and Chronomedicine
From Molecular and Cellular Mechanisms to Whole Body Interdigitating Networks
Av Germaine Cornelissen, Tsuyoshi Hirota
Inbunden, 2024
3515 kr
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Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for the difference between life and death in response to identical stimulus. The partly endogenous nature of circadian rhythms has been well documented and methods for their …
Chemical Biology of Phosphorus
Inbunden, 2020
3190 kr
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Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement: “where there is life, there is phosphorus”. Phosphorus chemical biology underlies most of life’s reactions and processes, from the covalent bonds that hold RNA and DNA together, to the making and spending 75 kg of …
DNA Damage, DNA Repair and Disease
Volume 2
Av Miral Dizdaroglu, R Stephen Lloyd
Inbunden, 2020
3260 kr
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The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and …
DNA Damage, DNA Repair and Disease
Two-volume Set
Av Miral Dizdaroglu, R Stephen Lloyd
2020
6644 kr
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The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and …
Chemical Biology of Nitrogen
Inbunden, 2021
3260 kr
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From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. …
Quorum Quenching
A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
Av Naga Raju Maddela, Ranjit Pabbati m. fl.
Inbunden, 2023
3296 kr
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Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new …
Chemical Biology of Carbon
Inbunden, 2023
3296 kr
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Building upon the previous volumes, The Chemical Biology of Sulfur, The Chemical Biology of Phosphorus, and The Chemical Biology of Nitrogen, this book examines the organic chemistry of life, The Chemical Biology of Carbon. It examines chemical biology open to carbon-containing natural metabolites …
Mechanisms of Primary Energy Transduction in Biology
Inbunden, 2017
3012 kr
Tillfälligt slut
This book describes the events of primary energy transduction in life processes. Life as we know it depends on pumping protons across membranes. New tools to study the protein complexes involved has led to recent intensified progress in the field. Primary Energy Transduction in Biology focusses on …
