Clinics in Developmental Medicine – serie

Congenital or early-onset disorders of the nervous system have a profound and lifelong impact on the lives of children and their families.  Diseases of the Nervous System in Childhood provides up-to-date information on the full range of these neurological disorders, from fetal and neonatal neurology to adolescence.Movement disorders, epilepsies and seizure disorders, metabolic diseases, auditory and visual disorders, and genetic anomalies are among the many topics covered in this text.  Extensive reference lists at the end of each chapter guide the clinician to further relevant reading.This fourth edition retains the patient-focussed, clinical approach of its predecessors. The international team of editors and contributors has honoured the request of the late Jean Aicardi, that his book remain ‘resolutely clinical’, which distinguishes Diseases of the Nervous System in Childhood from other texts in the field.This edition: Is completely revised and updatedIncludes latest developments in genetic advancesContains new chapters on basal ganglia diseases and psychogenic disordersHas an easy-to-use one volume format with full-colour illustrations

A Neurophysiological Basis for the Treatment of Cerebral Palsy, 2nd EditionThis extensively revised edition of one of the most popular of the Clinics series updates and clarifies the original work of Karel Bobath's account of the neurophysiological mechanisms underlying the motor disorders of cerebral palsy. It also highlights the advantages of very early treatment of infants before the disordered postures and movements are established. All those involved with physically handicapped children, and especially therapists, will find the book invaluable reading.

This Clinic in Developmental Medicine describes a meticulous survey of germinal matrix/intraventricular haemorrhage in preterm infants. The babies weighed 501-2000g at their birth in three New Jersey counties between 1984 and 1987. They were studied prospectively with cranial ultrasound; the findings were correlated with very detailed pathological examination of the brains of those who died, and with later outcome in the survivors. The numbers studied in this population-based sample were large enough both to test and to generate hypotheses about the causes and consequences of haemorrhage.

Photosensitive epilepsy is a relatively rare condition in which convulsions are precipitated by visual stimuli. The authors have spent almost 30 years studying this condition and have assembled the largest cohort of patients ever studied by one centre. Their previous book on the subject (1975) became the standard text on this condition. This book reviews the earlier studies, reviews all the literature on this condition in humans and details the many studies that have since been carried out, including studies on drug therapy, the long term prognosis for the condition, pattern sensitivity, video game epilepsy, and convulsions precipitated by other video material. In addition there is advice on procedures to reduce the risk of stimulation from television as well as such factors as the genetics of photosensitivity. This is the most comprehensive text available.

It is often difficult to decide whether a preschool child who does not communicate effectively has a developmental disorder limited to language, has behaviours that indicate autism with or without mental deficiency, or across-the-board mental deficiency without autistic features. All of these disorders denote abnormal brain development, but standard medical and neurologic examinations and tests such as brain imaging, EEGs, chromosome and chemical tests rarely provide an answer. Careful attention to the child's language and behaviour, ability to play creatively, and analysis of neuropsychologic tests and language are much more informative for arriving at a correct diagnosis. This is one of the largest multidisciplinary studies which has considered the problem of making a diagnosis among these often confusing and difficult to test young children and considers explicitly the practical consequences of using different criteria for making a diagnosis.

Disabled children often have feeding difficulty. Choking, food spillage and protracted mealtimes can pose enormous problems for their carers and the accompanying nutritional deficit imposes additional burdens on the affected child. The aetiology of these problems is placed in context by a detailed description of normal feeding development in infants. The often under-recognised nutritional and neurodevelopmental consequences of inadequate nutrient intake together with the respiratory complications and the important problems of constipation and drooling which may accompany oro-motor dysfunction are detailed. The clinical and nutritional assessment and the application of diagnostic imaging techniques in the evaluation of such children are described. The methods of management of these children's problems form the core of this volume and they range from oro-motor therapy to various techniques for enteral feeding. The ethical issues raised by the vigorous intervention needed to improve the nutritional state of severely disabled children is explored, together with the need to provide ongoing psychological support for their carers.

The central focus of this book is the development of skilled motor actions by children; commonplace but vital actions such as maintaining posture, walking, reaching and grasping, and manipulating objects and tools. It represents a state-of-the art report on motor development linking neurophysiological and neuropsychological approaches. Using examples from both normal and pathological development, contributions study pre and postnatal brain development and its relationship to movement, the importance of fetal movements, postural control in children, the neurobiology of locomotor development, neural mechanisms of grasping and typical patterns of behavioural change. New theoretical developments including adaptive model theory, dynamic systems theory, and the relationship between variability and stability in skill development are also critically reviewed.

This volume considers the neurodevelopmental disorders such as dyslexia, dyscalculia, dysgraphia, clumsiness and indeed all those learning difficulties to be found in a 'normal' school population with an IQ of more than 70. Specific ideas about the causes of these disorders are presented along with very practical preventative and management information which will be welcomed by a wide range of professionals with an interest in paediatrics, neurology, developmental and educational psychology.

This is a very practical book on the value of behavioural techniques in the treatment of children with various disorders including hyperactivity, conduct problems, autism and communication difficulties. Written by an international group of experts, it will provide practitioners in the field with a clear picture of the value of behavioural methodology. It also stresses the necessary assessment and evaluation procedures required in order to implement the techniques appropriately.

Clinics in Developmental Medicine No. 147 The hand is a remarkable organ which is characteristic of primates and most highly developed in man. This book deals with the evolution and development of hand function, with the structure of the hand and with the hand as a perceptual system. Neurophysiology and psychology of hand function are included, as are problems of disability. With expert interdisciplinary contributions from around the world, this wide-ranging overview is sure to be of value to all those interested in hand function, development, pathology and therapy.

Clinics in Developmental Medicine No. 148 This is the second edition of the manual describing a popular and practical tool for the clinical neurological examination of the newborn. In addition to a number of developments on the original scheme in the light of clinical and research experience, the new manual also facilitates the recording and performance of the examination by providing clear information on its administration, aided by illustrative diagrams. A new feature is the inclusion of useful scoring tables at the back of the book. Other new sections include a simplified version of the examination suited to inexperienced staff, applicable both for screening and for use in developing countries, and a revised proforma which may be used for the follow-up of infants beyond the neonatal period. There is also a new section describing clinical patterns in newborns with brain lesions and their correlation with imaging and neurological findings.

This book reviews clinical models for working with developmental disability and behavioural problems. The first section explores the causes and nature of behaviour problems amongst people with physical, learning, language and sensory disabilities, and some key specific conditions. The second section describes the assessment approaches that clinicians will find most useful in evaluating behaviour. The third section covers treatment approaches emphasising the importance of a broad, eclectic approach. The contributors, all acknowledged experts in their fields of paediatrics, psychology and psychiatry, provide a comprehensive overview of this set of major challenges, emphasising the importance of auditory detection, understanding, measurement and treatment.

Clinics in Developmental Medicine No. 152 Crying as a Sign, a Symptom and a Signal brings the reader up to date on new evidence concerning the developmental and clinical significance of infant crying in the first few months and years of life. Initially studied as a sign of disease, crying is now being understood not only as a sign, but also as a symptom of problematic functioning in early development. We now know much more about normative patterns of development of infant crying and how they may be manifest in a variety of clinical settings (emergency room complaint, painful procedures, colic, temper tantrums, non-verbal and mentally challenged infants). This has brought about a new conceptualization of the significance of early infant crying which an international team of experts describe and examine. In this authoritative clinical text, both historical and methodological perspectives are brought to a multidisciplinary synopsis of the new understanding of this infant behavior.

Autism is not a single disease but a syndrome of different diseases. In this completely reworked and updated third edition, two world authorities, Christopher Gillberg and Mary Coleman, address the difficulties this presents for clinical diagnosis with diagnostic aids and clear guidelines for medical evaluation. Epidemiology, neuropsychological studies and behavior complexes, such as self-injury, are reviewed in detail, and the authors give a detailed explanation of what is known about the molecular biology and genetics of autism. Epilepsy and electrophysiological studies are also covered, as well as biochemistry, endocrinology, immunology, brain imaging and neuropathology. The available medical therapies are reviewed, along with an update on what is known about other interventions, such as psychoeducational and behavioral modification procedures. The book concludes with an integration of current knowledge from diverse fields. This is an essential text for clinicians and will also be of interest to parents of autistic children.

Sleep disturbance is extremely common in the various disorders of development, be they physical or psychological in nature. It adds significantly to the burden of care but is a neglected topic and there is no single source of information to guide practice and management. In this book an international team of experts provides for the first time an integrated, comprehensive and up-to-date review of the nature and causes of sleep disorders, describing the special assessment and management considerations for each of the different developmental disorders. The book will be essential reading for all professionals working in the area of developmental disorders, and will also be of considerable interest to teachers, social workers and parents.

Clinics in Developmental Medicine No. 161 Since the first edition of this book was published in 1984 the intensive debates about the 'correct' method of treatment for children with cerebral palsy have been resolved and it is now possible to describe what is generally agreed to be the optimal approach. This entirely rewritten new edition describes the most up-to-date thinking, with two new editors from America and Australia reflecting the worldwide picture. Coverage includes the coordination of care and the management team; the types of cerebral palsy; assessment; goal-setting; learning and neural plasticity; global therapeutic approaches as well as more focused (topical) therapies; the mechanisms of deformity, its prevention and treatment; and the transition to adult life. This book details the advancement of the subject from 1984 to 2002.

Clinics in Developmental Medicine No. 160 Children with craniosynostosis are born with congenital deformities of the face and skull. In severe cases associated problems are common. The child who is not properly cared for can end up blind, deaf and with severe learning difficulties. In addition, they may be left with unacceptable facial deformities. Outside specialized craniofacial units, there is at present nowhere for those involved in primary or secondary care to go for help with the many practical problems that these children present. In this book, a distinguished team of editors have assembled experts in the field to introduce the non-craniofacial specialist to what can be achieved and how they can contribute to the child's welfare. It will be essential reading for paediatricians seeking practical information about the management of these disorders, and for specialists in neurosurgery, ENT, ophthalmology, plastic surgery, maxillo-facial surgery, orthodontics, psychology, genetics, anaesthesia, audiology and speech therapy.

Clinics in Developmental Medicine No. 162 The Research Programme on Shaken Baby Syndrome in Edinburgh is internationally recognised for its prominent ongoing research into the epidemiology, bio-mechanics, primary and secondary brain insults, neuroradiological aspects, medical-social aspects, and neurodevelopmental and neuropsychometric sequelae of shaking a baby. In this book, a highly distinguished team of experts from the programme present the clinician with the latest findings on the syndrome, covering the diagnosis of the syndrome itself and the long-term disability that results which, unlike other forms of child abuse associated with psychological scars, is also associated with a high degree of life-long physical and intellectual disability. This will be invaluable reading for all professionals concerned with diagnosing and treating this syndrome.

Clinics in Developmental Medicine No.166 Ranging from epidemiology and neuroimaging through the general principles of surgery and radiotherapy/chemotherapy to issues of palliative care and quality of life, this concise, broad-ranging and practical text covers all clinical aspects of central nervous system tumours in children. It provides an overview of current important issues in diagnosis and management, and focuses on important areas of research, with an emphasis on the areas likely to impact on clinical practice. It will be essential reading for paediatric oncologists, medical and clinical oncologists, neurosurgeons, and paediatricians involved in the care of children with brain tumours, trainees in these and related specialties, specialist nurses and paramedical staff.

Clinics in Developmental Medicine No. 170 Elimination disorders (nocturnal enuresis, urinary incontinence and encopresis) are among the most common disorders of childhood. Some disorders are primarily genetically determined, in others environmental factors predominate. Also, the rate of comorbid behavioural disturbances differs greatly from one syndrome to another. Because of this variety and heterogeneity, each disorder requires specific approaches in assessment and treatment. This book provides an evidence-based overview of functional elimination disorders. It draws on the standardisation and terminology suggested by the International Children's Continence Society. Short case vignettes, photos and line drawings, as well as questionnaires and charts are provided. To enable a quick orientation for clinical purposes, each chapter is followed by summaries, guidelines and diagrams. It will be of interest to all professionals working in the field.

Clinics in Developmental Medicine No. 171 The last 10 years have seen major advances in the scientific understanding of ADHD. This book builds on them to provide a practical, comprehensive and evidence-based approach to clinical work with ADHD and hyperkinetic disorder, and to similar problems in people with complex neurodevelopmental disabilities. This is a book for professionals of all kinds who deal with hyperactive children and people with ADHD. It explains the science base of understanding it and gives practical step-by-step instructions on how to treat it - including informative leaflets for parents and teachers.

Clinics in Developmental Medicine No. 172A comprehensive book dealing with drug, tobacco and alcohol abuse in both children and young people. Presents the facts of drug and alcohol abuse, evidence for prevention and treatment, and reviews of the various types of treatmentsReviews all drugs of abuse, including tobacco and alcoholOffers a practical presentation of evidence from particular therapies, such as cognitive behavioural therapy and family therapyPresents a comprehensive review of the pharmacological advances for this age group with substance use disorders and other mental health problemsWritten by an international team of professionals and academics, each with a background in adolescent development as well as addiction.

Clinics in Developmental Medicine No. 175 Orthoses are externally applied medical devices used to prevent or correct musculoskeletal deformities and improve physical functioning; these devices are typically custom made. This is one of very few books on the subject of orthotics published in recent years and the only book focusing solely on the orthotic management of children. The first part of the book considers the principles that are fundamental to orthotic management, including a review of biomechanics, consideration of clinical assessment methods, and the materials and fabrication techniques used to make orthoses. The second part of the book comprises several condition-specific chapters that consider the appropariate orthotic management of the more common conditions in childhood in the context of multidisciplinary care. The chapters include neuromuscular conditions such as cerebral palsy, myelomeningocoele and muscular dystrophy; and also congenital deformities and conditions arising in childhood. One chapter considers orthotic intervention for idiopathic scoliosis and another considers the sometimes controversial issue of protective and corrective headwear. Whist by no means exhaustive, Paediatric Orthotics provides both a basic grounding in the subject together with practical guidance to help clinical practice. Paediatric Orthotics will be of use, not only to orthotists but also to physical and occupational therapists, paediatricians, paediatric orthopaedic surgeons and physiatrists. The book is also essential reading for all students and clinicians involved in the physical management of children with disabilities.

Clinics in Developmental Medicine No. 178 For most children with cerebral palsy, the extent to which they can use their hands is critical to their overall development. Over the last two decades there have been major advances in the understanding of hand function. Particularly in children with cerebral palsy, assessment of hand function has become more exact and the range of possible interventions has expanded. Changes in treatment approaches can be seen in neurorehabilitation, orthopaedic management, developmental pediatrics and rehabilitation including occupational and physical therapy practices. In this book, selected experts from around the world in the fields of neuroimaging, neurology, orthopaedics, anatomy, motor control and motor learning provide fundamental theoretical information for the development of hand function in children with cerebral palsy. The book also shows how theory can be translated into practice by clinicians who provide assessment and intervention services to improve hand use in this population in sections written by researchers in occupational and physical therapy. Linking different fields of knowledge, this book highlights new perspectives and provides the best evidence for different types of intervention. By focusing only on hand function this essential book highlights new concepts for clinicians and others working towards the overall well-being of children with cerebral palsy.

Clinics in Developmental Medicine No. 176 The book provides a review of the state of the art of neurological assessment in the first two years of life and identifies the most appropriate instruments for the follow-up of newborns who are at risk of developing neurological abnormalities.After a brief description of the neurophysiological basis of development in the first years, the book provides a comprehensive review of the various methods used for the neurological assessment in young infants describing how a combined approach of clinical and instrumental investigations can provide important diagnostic and prognostic information.The first part of the book describes the most used clinical neurological examinations and their applications in infants with neurological abnormalities, followed by a description of the value of neuroimaging and neurophysiological techniques in normal preterm and full term infants in the first two years and the main types of abnormal MR findings of neurophysiological findings (EEG and evoked potentials) in relation to brain lesions.Other sections include chapters describing techniques assessing specific aspects of cognitive, perceptual and sensory abilities. Special attention is given to hearing, language and communication and to development of vision and visual attention both in normal infants and in those with neonatal brain lesions.The final chapters are devoted to intervention, describing how the identification of specific profiles of impairment can lead to the development of appropriate plans of early intervention.

Clinics in Developmental Medicine No. 177 This book provides a comprehensive review of clinical and genetic issues, natural history, possible pathophysiological pathways, specific clinical problems (motor impairment, behaviour, learning difficulties, communication, sleep, epilepsy), clinical neurophysiology, neuropathology, rehabilitation and basic research in the field of Angelman syndrome. This condition is a neurogenetic disorder characterised by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioural phenotype. It is caused by the lack of expression of the UBE3A gene associated with various abnormalities of chromosome 15q11-13.Angelman syndrome appears to be distributed equally worldwide. Precise diagnosis carries clinical and genetic counselling implications. However, many clinicians still seem unfamiliar with this condition despite the severity and typical aspects of presentation. Beyond individual situations, Angelman syndrome can serve as a disease model opening broad questioning of genetic and epigenetic influences in neurology, as well as of several concepts such as psychomotor development, cerebral palsy, behavioural phenotypes and epileptic syndromes.Recent advances in molecular biology and animal models of the syndrome have provided new data which can improve our understanding of Angelman syndrome and open the way to more specific management.

This Atlas covers the entire spectrum of brain disease as studied with ultrasound, illustrated throughout with superb-quality images. It is aimed at neonatologists and radiologists confronted with everyday clinical questions on the neonatal ward. Most newborn brain disorders can be identified with ultrasound; this book will therefore be particularly useful in settings with limited MRI facilities. Prenatal ultrasound specialists will also find it valuable as a postnatal reference in their field of interest. Suggestions for differential diagnosis accompany all the sonographic findings, guiding the clinician in proceeding from an abnormal image to a diagnosis. This second edition of the Atlas has been brought up to date to include the many advances in technique and interpretation that have been made in the past decade. The images have been replaced with new ones of higher quality, and all the line artwork has been standardised and improved. ReadershipNeonatologists, radiologists, neuroradiologists with an interest in neonatal ultrasoundFrom reviews of the first edition:"This is the most challenging and comprehensive book on this theme, and is an essential reference for clinicians to make a correct diagnosis."—Satoshi Takada, Brain and Development"This can be little doubt that this title represents the definitive work on neonatal cranial ultrasound. The authors have had extensive experience in the use of ultrasound scanning the neonatal brain for almost as long as ultrasound has been used to investigate intracranial pathology on the neonatal unit. Their combined experience is most impressive."—Malcolm Leven, Archives of Disease in Childhood

Clinics in Developmental Medicine No. 179 The complex nature of the postural control system makes it vulnerable to adverse conditions during early life, such as prenatally or perinatally acquired lesions of the brain or preterm birth. Children with disorders of the developing brain nearly always have dysfunctions in postural control. The postural control system of children with other neurodevelopmental disabilities such as myelomeningocele or muscle disease is also challenged: it has to find age-specific solutions for the postural problems posed by the disorder. These postural problems have serious consequences for the activities of daily life, as adequate postural control is a prerequisite for adequate motility.Until now, knowledge about the nature of postural problems in children has been scattered, and this has hampered the development of appropriate therapeutic management strategies. This book is a breakthrough in that it introduces the reader to the complexity of typical and atypical postural development and provides suggestions for the day-to-day management of postural problems in children with developmental disorders such as cerebral palsy, developmental coordination disorder, muscle disorder and myelomeningocoele.“This should be a ‘must read’ for anyone whose occupation or interests are in the areas of motor development or rehabilitation” Diane Damiano.