NATO Science for Peace and Security Series A: Chemistry and Biology – serie
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Inbunden, Engelska, 2007
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The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].
Häftad, Engelska, 2007
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The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].
Inbunden, Engelska, 2007
1 668 kr
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This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting “Stem Cells and their potential for clinical application” which took place from August 23 – 25, 2006 in Kyiv and from August 26 – 31, 2006 in Simeiz, Ukraine. The meeting was devoted to “hot topics” in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference’s main topics, the book is divided into five chapters - “Haematopoietic stem cells and haematopoiesis”, “Biology of n- haematopoietic stem cells”, “Stem cells and malignancy”, “Cell processing; expansion and genetic modification” and “Clinical haematopoietic stem cell transplantation”.
Häftad, Engelska, 2007
1 668 kr
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This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting “Stem Cells and their potential for clinical application” which took place from August 23 – 25, 2006 in Kyiv and from August 26 – 31, 2006 in Simeiz, Ukraine. The meeting was devoted to “hot topics” in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference’s main topics, the book is divided into five chapters - “Haematopoietic stem cells and haematopoiesis”, “Biology of n- haematopoietic stem cells”, “Stem cells and malignancy”, “Cell processing; expansion and genetic modification” and “Clinical haematopoietic stem cell transplantation”.
Inbunden, Engelska, 2008
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Plasma decontamination is a rapidly expanding area of modern science and engineering. An increasing number of engineers are using plasma methods for decontamination of chemical and biological agents. Plasma decontamination is effectively applied today to clean and sterilize different surfaces, high volume air and water streams, industrial exhausts, and even living tissue of animals and humans. This book provides a fundamental introduction to virtually all aspects of modern plasma decontamination, as well as the most recent technological achievements in the area.The book is segmented into four specific sections of modern plasma decontamination: (1) plasma bio-decontamination, including disinfection and sterilization of surfaces, water and air streams; (2) plasma decontamination of chemical agents, including cleaning of air, water, and industrial exhaust gases from different pollutants and especially volatile organic compounds VOC; (3) plasma treatment of living tissue, including different subjects of plasma medicine from skin sterilization to tissue engineering; (4) major electric discharges applied for the plasma-assisted decontamination of chemical and biological agents.
Häftad, Engelska, 2008
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Plasma decontamination is a rapidly expanding area of modern science and engineering. An increasing number of engineers are using plasma methods for decontamination of chemical and biological agents. Plasma decontamination is effectively applied today to clean and sterilize different surfaces, high volume air and water streams, industrial exhausts, and even living tissue of animals and humans. This book provides a fundamental introduction to virtually all aspects of modern plasma decontamination, as well as the most recent technological achievements in the area.The book is segmented into four specific sections of modern plasma decontamination: (1) plasma bio-decontamination, including disinfection and sterilization of surfaces, water and air streams; (2) plasma decontamination of chemical agents, including cleaning of air, water, and industrial exhaust gases from different pollutants and especially volatile organic compounds VOC; (3) plasma treatment of living tissue, including different subjects of plasma medicine from skin sterilization to tissue engineering; (4) major electric discharges applied for the plasma-assisted decontamination of chemical and biological agents.
Inbunden, Engelska, 2008
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This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. The Institute was sponsored and funded by the Scientific Affairs Division of NATO. It is my pleasant duty to thank this institution. This ASI offered updated information on how far the research on algal toxins has gone in the exploration of structures, biosynthesis and regulation of toxins, and the development of technology for bio-monitoring these c- pounds. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
Häftad, Engelska, 2008
2 158 kr
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This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. The Institute was sponsored and funded by the Scientific Affairs Division of NATO. It is my pleasant duty to thank this institution. This ASI offered updated information on how far the research on algal toxins has gone in the exploration of structures, biosynthesis and regulation of toxins, and the development of technology for bio-monitoring these c- pounds. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
Inbunden, Engelska, 2008
1 620 kr
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Mass spectrometry (MS) along with its hyphenated techniques is capable of high throughput, sensitivity, accuracy and selectivity for the analysis of structure and composition of almost any product. Like in electrophoresis, MS separates mo- cules based on the mass-to-charge ratio. In case of gel electrophoresis (SDS- PAGE), a well-known and efficient bioanalytical technique, proteins bear negative charges but have the same charge density, so proteins are separated according to their size. Similarly, in case of MS analysis, proteins carry the same charge, and are separated by their molecular weight. Unlike SDS-PAGE, however, modern ultra high resolution MS discerns very small mass differences and can resolve and completely identify in a single experiment species of the same nominal mass in complex biological mixtures. Consequently, MS can be used for the structural characterization, identification and sensitive detection of mixtures of biomolecules or for assessing the quality of isolated proteins (purity, integrity, or post-translational modifications, for example), carbohydrates, nucleic acids, drugs, metabolites, pollutants etc. In the post-genome era, MS is continuously developing as one of the most re- able analytical method for elucidating the structure of molecules originating from various biological matrices. The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.
Häftad, Engelska, 2008
1 620 kr
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Mass spectrometry (MS) along with its hyphenated techniques is capable of high throughput, sensitivity, accuracy and selectivity for the analysis of structure and composition of almost any product. Like in electrophoresis, MS separates mo- cules based on the mass-to-charge ratio. In case of gel electrophoresis (SDS- PAGE), a well-known and efficient bioanalytical technique, proteins bear negative charges but have the same charge density, so proteins are separated according to their size. Similarly, in case of MS analysis, proteins carry the same charge, and are separated by their molecular weight. Unlike SDS-PAGE, however, modern ultra high resolution MS discerns very small mass differences and can resolve and completely identify in a single experiment species of the same nominal mass in complex biological mixtures. Consequently, MS can be used for the structural characterization, identification and sensitive detection of mixtures of biomolecules or for assessing the quality of isolated proteins (purity, integrity, or post-translational modifications, for example), carbohydrates, nucleic acids, drugs, metabolites, pollutants etc. In the post-genome era, MS is continuously developing as one of the most re- able analytical method for elucidating the structure of molecules originating from various biological matrices. The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.
Inbunden, Engelska, 2026
2 480 kr
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This book offers a forward-looking perspective on the convergence of artificial intelligence (AI) and biotechnology, and its transformative impact on synthetic biology. As these fields evolve rapidly, their integration is reshaping science, industry, and society in profound ways.Through a collection of rigorously researched chapters, the volume provides a comprehensive analysis of this dynamic relationship, offering valuable insights for researchers, practitioners, policymakers, and educators.I Convergence of AI and BiotechnologyAn overview of how AI-driven analytics and machine learning are revolutionizing biotechnological applications, enabling innovative solutions and breakthroughs in synthetic biology.II Modernization of BiotechnologyA comparative look at traditional methods versus AI-enhanced approaches in areas such as drug discovery, genetic engineering, and bioinformatics, highlighting increased precision and accelerated progress.III Governance, Risk, and ELSIExamining the ethical, legal, and social implications (ELSI) of AI-biotech integration, this section discusses frameworks for responsible innovation, emphasizing transparency and public engagement.IV Information HazardsA critical exploration of data privacy, security risks, and ethical dilemmas arising from the convergence of these technologies, with strategies to mitigate potential harms while maximizing societal benefits.This book is an essential resource for understanding the evolving landscape of synthetic biology and the broader implications of AI-biotech convergence.
Inbunden, Engelska, 2009
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This volume comprises papers presented at the 40th Erice Course "From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism", May 29 to June 8, 2008. The papers span the breadth of material presented, which emp- size the practical aspects of modern macromolecular crystallography and its applications to medicine. Topics addressed span from the selection of targets, through to structure determination, interpretation and exploitation. A particular theme that emerges is the dependence of modern structural science on multiple experimental and computational techniques. It is both the development of these techniques and their integration that will take us forward in the future. The NATO ASI directors worked alongside, and offer deep gratitude to Prof. Sir Tom Blundell, Director of the International School of Crystal- graphy, Dr Colin Groom, Dr Neera Borkakoti, Dr John Irwin and Prof. Lodovico Riva di Sanseverino, who were in turn supported by a number of local facilitators. The course was financed by NATO as an Advanced Study Institute.Additional support was given by the European Crystallographic Association, the International Union of Biochemistry and Molecular Biology, the Int- national Union of Crystallography, the University of Bologna, AstraZeneca, Roche, Merck & Co., Boehringer Ingelheim, Bruker Corporation, Douglas Instruments, Informa UK, the Department of Pharmaceutical Chemistry, TTP Lab Tech, University of California at San Francisco. Joel L. Sussman and Paola Spadon
Häftad, Engelska, 2009
1 115 kr
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This volume comprises papers presented at the 40th Erice Course "From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism", May 29 to June 8, 2008. The papers span the breadth of material presented, which emp- size the practical aspects of modern macromolecular crystallography and its applications to medicine. Topics addressed span from the selection of targets, through to structure determination, interpretation and exploitation. A particular theme that emerges is the dependence of modern structural science on multiple experimental and computational techniques. It is both the development of these techniques and their integration that will take us forward in the future. The NATO ASI directors worked alongside, and offer deep gratitude to Prof. Sir Tom Blundell, Director of the International School of Crystal- graphy, Dr Colin Groom, Dr Neera Borkakoti, Dr John Irwin and Prof. Lodovico Riva di Sanseverino, who were in turn supported by a number of local facilitators. The course was financed by NATO as an Advanced Study Institute.Additional support was given by the European Crystallographic Association, the International Union of Biochemistry and Molecular Biology, the Int- national Union of Crystallography, the University of Bologna, AstraZeneca, Roche, Merck & Co., Boehringer Ingelheim, Bruker Corporation, Douglas Instruments, Informa UK, the Department of Pharmaceutical Chemistry, TTP Lab Tech, University of California at San Francisco. Joel L. Sussman and Paola Spadon
Inbunden, Engelska, 2009
2 222 kr
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The terrorist act with sarin gas in the Tokyo underground and the case with the spread of anthrax spores through the U.S. postal system stimulated the development of orga- zation of fight against terrorism on a national and global level. The goal of this wo- shop was assessment of scientific concepts and practical means for management of chemical and biological agents casualties in the area of terrorist attacks with emphasis on improving the problems and situation in Eastern European Countries. In this book are included the results of both theoretical and practical research of chemical and biological terrorism presented during the workshop. Different trends of research to fight against terrorism on both local and governmental level including some Eastern European countries are discussed. The scientific articles are grouped into those areas: – New approaches in counteraction to chemical and biological terrorism – Medical treatment and decontamination of casualties from chemical and biological agents – Diagnosis of exposure to chemical and biological agents – Development of protection against injuries from chemical and biological agents In these articles the following are emphasized: – Some aspects of national and global defense against chemical and biological terrorism – National action plans and global agreements on combating terrorism – The characteristics of the major specific injuries connected with chemical and biological terrorism – Threats of terroristic attacks – Epidemiological and clinical peculiarities, ways of diagnosing, medical tre- ment and preventive health care measures These problems are analyzed from an interdisciplinary perspective.
Häftad, Engelska, 2009
2 222 kr
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The terrorist act with sarin gas in the Tokyo underground and the case with the spread of anthrax spores through the U.S. postal system stimulated the development of orga- zation of fight against terrorism on a national and global level. The goal of this wo- shop was assessment of scientific concepts and practical means for management of chemical and biological agents casualties in the area of terrorist attacks with emphasis on improving the problems and situation in Eastern European Countries. In this book are included the results of both theoretical and practical research of chemical and biological terrorism presented during the workshop. Different trends of research to fight against terrorism on both local and governmental level including some Eastern European countries are discussed. The scientific articles are grouped into those areas: – New approaches in counteraction to chemical and biological terrorism – Medical treatment and decontamination of casualties from chemical and biological agents – Diagnosis of exposure to chemical and biological agents – Development of protection against injuries from chemical and biological agents In these articles the following are emphasized: – Some aspects of national and global defense against chemical and biological terrorism – National action plans and global agreements on combating terrorism – The characteristics of the major specific injuries connected with chemical and biological terrorism – Threats of terroristic attacks – Epidemiological and clinical peculiarities, ways of diagnosing, medical tre- ment and preventive health care measures These problems are analyzed from an interdisciplinary perspective.
Inbunden, Engelska, 2009
1 082 kr
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The NATO ARW "Molecular Self-Organization in Micro-, Nano-, and Macro- Dimensions: From Molecules to Water, to Nanoparticles, DNA and Proteins" to commemorate Professor Alexander S. Davydov was held in Kiev, Ukraine, on 8-12 June, 2008, at the Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine. Theobjective ofthisNATOARWistounveilandformulatetheprincipalfeatures that govern myriads of the molecular self-organization processes in micro-, nano-, and macro-dimensions from the following key representatives such as liquid - ter and aqueous solutions, and molecular liquids, nanodots, nanoparticles including gold, solitons, biomolecules such as DNA and proteins, biopolymers and bios- sors, catalysis, molecular modeling, molecular devices, and thin ?lms, and to offer another, more advanced directions in computational, experimental, and technolo- cal areas of nano- and bioscience towards engineering novel and powerful molecular self-organized assemblies with tailored properties. Nanoscience is indeed one of the most important research and development fr- tiers in modern science.Simplistically, nanoscience is the science of small particles of materials of a size of nanometre. Molecular nanoscience and nanotechnology have brought to us the unprecedented experimental control of the structure of matter with novel extraordinary properties that open new horizons and new opportunities, and new ways to make things, particularly in our everyday life, to heal our bodies, and to care of the environment. Unfortunately, they have also brought unwelcome advances in weaponry and opened yet more ways to foul up the world on an en- mous scale.
Häftad, Engelska, 2009
1 082 kr
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The NATO ARW "Molecular Self-Organization in Micro-, Nano-, and Macro- Dimensions: From Molecules to Water, to Nanoparticles, DNA and Proteins" to commemorate Professor Alexander S. Davydov was held in Kiev, Ukraine, on 8-12 June, 2008, at the Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine. Theobjective ofthisNATOARWistounveilandformulatetheprincipalfeatures that govern myriads of the molecular self-organization processes in micro-, nano-, and macro-dimensions from the following key representatives such as liquid - ter and aqueous solutions, and molecular liquids, nanodots, nanoparticles including gold, solitons, biomolecules such as DNA and proteins, biopolymers and bios- sors, catalysis, molecular modeling, molecular devices, and thin ?lms, and to offer another, more advanced directions in computational, experimental, and technolo- cal areas of nano- and bioscience towards engineering novel and powerful molecular self-organized assemblies with tailored properties. Nanoscience is indeed one of the most important research and development fr- tiers in modern science.Simplistically, nanoscience is the science of small particles of materials of a size of nanometre. Molecular nanoscience and nanotechnology have brought to us the unprecedented experimental control of the structure of matter with novel extraordinary properties that open new horizons and new opportunities, and new ways to make things, particularly in our everyday life, to heal our bodies, and to care of the environment. Unfortunately, they have also brought unwelcome advances in weaponry and opened yet more ways to foul up the world on an en- mous scale.
Inbunden, Engelska, 2009
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The present volume includes most of the material of the invited lectures delivered at the NATO Advanced Study Institute “Morphogenesis through the interplay of nonlinear chemical instabilities and elastic active media” held from 2th to 14th July 2007 at the Institut d’Etudes Scientifiques de Cargèse (http://www.iesc.univ-corse.fr/), in Corsica (France). This traditional place to organize Summer Schools and Workshops in a well equipped secluded location at the border of the Mediterranean sea has, over many years now, earned an increasing deserved reputation. Non-linear dynamics of non equilibrium systems has worked its way into a great number of fields and plays a key role in the understanding of se- organization and emergence phenomena in domains as diverse as chemical reactors, laser physics, fluid dynamics, electronic devices and biological morphogenesis. In the latter case, the viscoelastic properties of tissues are also known to play a key role. The control and formulation of soft responsive or “smart” materials has been a fast growing field of material science, specially in the area of po- mer networks, due to their growing applications in bio-science, chemical sensors, intelligent microfluidic devices, … . Nature is an important p- vider of active materials whether at the level of tissues or at that of s- cellular structures. As a consequence, the fundamental understanding of the physical mechanisms at play in responsive materials also shines light in the understanding of biological artefacts.
Häftad, Engelska, 2009
1 082 kr
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The present volume includes most of the material of the invited lectures delivered at the NATO Advanced Study Institute “Morphogenesis through the interplay of nonlinear chemical instabilities and elastic active media” held from 2th to 14th July 2007 at the Institut d’Etudes Scientifiques de Cargèse (http://www.iesc.univ-corse.fr/), in Corsica (France). This traditional place to organize Summer Schools and Workshops in a well equipped secluded location at the border of the Mediterranean sea has, over many years now, earned an increasing deserved reputation. Non-linear dynamics of non equilibrium systems has worked its way into a great number of fields and plays a key role in the understanding of se- organization and emergence phenomena in domains as diverse as chemical reactors, laser physics, fluid dynamics, electronic devices and biological morphogenesis. In the latter case, the viscoelastic properties of tissues are also known to play a key role. The control and formulation of soft responsive or “smart” materials has been a fast growing field of material science, specially in the area of po- mer networks, due to their growing applications in bio-science, chemical sensors, intelligent microfluidic devices, … . Nature is an important p- vider of active materials whether at the level of tissues or at that of s- cellular structures. As a consequence, the fundamental understanding of the physical mechanisms at play in responsive materials also shines light in the understanding of biological artefacts.
Inbunden, Engelska, 2009
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Control over macromolecular architecture and resulting material properties has been a central goal of polymer chemistry. There has been much interest in developing new synthetic routes to prepare smart materials with novel compositions and topologies for various applications. The considerable progress in the metal mediated macromolecular engineering over the past decade has had a major impact on the development of well-defined macromolecular architectures and the synthesis of smart materials. Particularly, remarkable strong developments have been observed for the synthesis of smart materials via four metal mediated macromolecular engineering techniques; Anionic, ROMP, ATRP and Click Chemistry. These materials have found uses in advanced microelectronics, technical and biomedical applications as well as in chemical sensors applications.This book is comprised of 27 chapters written by leading scientists from NATO and Partner Countries who have greatly contributed in the area of Anionic, ROMP, ATRP and Click Chemistry. It highlights the fundamental aspects and recent developments of these four powerful techniques and evaluate their potential in the syntheses of smart materials from complex structures (grafts, brushes, dendrimers, etc.) to nanostructures (self-assembly, nano-size, etc) for a wide range of applications.The book reports on the synthesis of a wide range of well-defined complex polymeric systems such as thermoresponsive smart polymers, star copolymers, biocompatible polymers, amphipilic smart nano structured, conducting polymers, self assembled polymers, and hyperbranced polymers.
Häftad, Engelska, 2009
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Control over macromolecular architecture and resulting material properties has been a central goal of polymer chemistry. There has been much interest in developing new synthetic routes to prepare smart materials with novel compositions and topologies for various applications. The considerable progress in the metal mediated macromolecular engineering over the past decade has had a major impact on the development of well-defined macromolecular architectures and the synthesis of smart materials. Particularly, remarkable strong developments have been observed for the synthesis of smart materials via four metal mediated macromolecular engineering techniques; Anionic, ROMP, ATRP and Click Chemistry. These materials have found uses in advanced microelectronics, technical and biomedical applications as well as in chemical sensors applications.This book is comprised of 27 chapters written by leading scientists from NATO and Partner Countries who have greatly contributed in the area of Anionic, ROMP, ATRP and Click Chemistry. It highlights the fundamental aspects and recent developments of these four powerful techniques and evaluate their potential in the syntheses of smart materials from complex structures (grafts, brushes, dendrimers, etc.) to nanostructures (self-assembly, nano-size, etc) for a wide range of applications.The book reports on the synthesis of a wide range of well-defined complex polymeric systems such as thermoresponsive smart polymers, star copolymers, biocompatible polymers, amphipilic smart nano structured, conducting polymers, self assembled polymers, and hyperbranced polymers.
Inbunden, Engelska, 2009
2 158 kr
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recently discovered advantages of amorphous forms of medicines/pharmaceutical products which focused a significant part of industry-related efforts on the GFA (Glass Forming Ability) and the glass temperature (T) versus pressure g dependences. 1 b ? 0 ? ? o ? P ? Pg P ? Pg 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g ? 0 ? ? ? ? c + Pg ? ? ? ? 400 1 b 0 o ? ? ? ? P ? P P ? P g g 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g 0 ? ? ? ? c ? + P max g ? ? ? ? T ~7 GPa g max P ~ 304 K Liquid g 300 1 HS glass 0 200 -1 mSG ?=0. 044 Liquid -2 100 -3 glass ?=0. 12 -1. 2 -0. 9 -0. 6 -0. 3 0. 0 log T 10 scaled -1 0 1 2 3 4 5 6 7 8 9 10 11 12 P (GPa) g 19 Figure 1. T he pressure evolution of the glass temperature in gl Th ye s cerol ol . id curve shows the parameterization of experimental data via the novel, modifie d Glat Sizm elon type equation, given in the Figure.
Häftad, Engelska, 2009
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recently discovered advantages of amorphous forms of medicines/pharmaceutical products which focused a significant part of industry-related efforts on the GFA (Glass Forming Ability) and the glass temperature (T) versus pressure g dependences. 1 b ? 0 ? ? o ? P ? Pg P ? Pg 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g ? 0 ? ? ? ? c + Pg ? ? ? ? 400 1 b 0 o ? ? ? ? P ? P P ? P g g 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g 0 ? ? ? ? c ? + P max g ? ? ? ? T ~7 GPa g max P ~ 304 K Liquid g 300 1 HS glass 0 200 -1 mSG ?=0. 044 Liquid -2 100 -3 glass ?=0. 12 -1. 2 -0. 9 -0. 6 -0. 3 0. 0 log T 10 scaled -1 0 1 2 3 4 5 6 7 8 9 10 11 12 P (GPa) g 19 Figure 1. T he pressure evolution of the glass temperature in gl Th ye s cerol ol . id curve shows the parameterization of experimental data via the novel, modifie d Glat Sizm elon type equation, given in the Figure.
Inbunden, Engelska, 2009
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An outstanding international scientific event in the field of metathesis chemistry, the NATO ASI "Green Metathesis Chemistry: Great Challenges in Synthesis, Catalysis and Nanotechnology" has been recently organized in Bucharest, Romania (July 21- August 2, 2008). Numerous renowned scientists, young researchers and students, convened for two weeks to present and debate on the newest trends in alkene metathesis and identify future perspectives in this fascinating area of organic, organometallic, catalysis and polymer chemistry with foreseen important applications in materials science and technology. Following the fruitful practice of NATO Advanced Study Institutes, selected contributions covering plenary lectures, short communications and posters have been compiled in this special volume dedicated to this successful convention on green metathesis chemistry.General interest was primarily focused on relevant "green chemistry" features related to all types of metathesis reactions (RCM, CM, enyne metathesis, ADMET and ROMP). Diverse opportunities for green and sustainable technologies and industrial procedures based on metahesis have been identified. Largely exemplified was the utility of this broadly applicable strategy in organic synthesis, for accessing natural products and pharmaceuticals, and also its ability to fit in the manufacture of smart and nanostructured materials, self-assemblies with nanoscale morphologies, macromolecular engineering.
Häftad, Engelska, 2009
2 158 kr
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An outstanding international scientific event in the field of metathesis chemistry, the NATO ASI "Green Metathesis Chemistry: Great Challenges in Synthesis, Catalysis and Nanotechnology" has been recently organized in Bucharest, Romania (July 21- August 2, 2008). Numerous renowned scientists, young researchers and students, convened for two weeks to present and debate on the newest trends in alkene metathesis and identify future perspectives in this fascinating area of organic, organometallic, catalysis and polymer chemistry with foreseen important applications in materials science and technology. Following the fruitful practice of NATO Advanced Study Institutes, selected contributions covering plenary lectures, short communications and posters have been compiled in this special volume dedicated to this successful convention on green metathesis chemistry.General interest was primarily focused on relevant "green chemistry" features related to all types of metathesis reactions (RCM, CM, enyne metathesis, ADMET and ROMP). Diverse opportunities for green and sustainable technologies and industrial procedures based on metahesis have been identified. Largely exemplified was the utility of this broadly applicable strategy in organic synthesis, for accessing natural products and pharmaceuticals, and also its ability to fit in the manufacture of smart and nanostructured materials, self-assemblies with nanoscale morphologies, macromolecular engineering.
Inbunden, Engelska, 2010
2 222 kr
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This publication represents the result of the fruitful workshop organised with the aim to attract the attention on the possibility of bio terrorism attack, with the s- port of NATO funds. In the last years the attention was strongly concentrated on the terrorism view similar to “military type attacks:” bomb on the trains, kamikazes, airplanes etc. As consequence many devices studied are directed to prevent these attacks such as the control of the passengers before the flight. For the people terrorism is therefore equivalent to bomb or similar and nobody think that there is also other possible and sophisticated means that can be used by the terrorist. In 1995 Sarin gas in the Tokio subway killed 12 people and affected 5,000 persons. In the USA anthrax was sent by mail to many federal offices. These events and other cases attract the attention on these possible terrorist attacks and the first recommendations for preventing theses events were\elaborated in the United State and in Europe. The possible agents and the modality that can be used for the diffusion are analysed and food and water are considered the principal and more favourable way. The story and the principal decision about this were reported in the first article of this collection which introduces the concept of bio-terrorism.
Häftad, Engelska, 2010
2 222 kr
Skickas inom 10-15 vardagar
This publication represents the result of the fruitful workshop organised with the aim to attract the attention on the possibility of bio terrorism attack, with the s- port of NATO funds. In the last years the attention was strongly concentrated on the terrorism view similar to “military type attacks:” bomb on the trains, kamikazes, airplanes etc. As consequence many devices studied are directed to prevent these attacks such as the control of the passengers before the flight. For the people terrorism is therefore equivalent to bomb or similar and nobody think that there is also other possible and sophisticated means that can be used by the terrorist. In 1995 Sarin gas in the Tokio subway killed 12 people and affected 5,000 persons. In the USA anthrax was sent by mail to many federal offices. These events and other cases attract the attention on these possible terrorist attacks and the first recommendations for preventing theses events were\elaborated in the United State and in Europe. The possible agents and the modality that can be used for the diffusion are analysed and food and water are considered the principal and more favourable way. The story and the principal decision about this were reported in the first article of this collection which introduces the concept of bio-terrorism.
Inbunden, Engelska, 2010
2 222 kr
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This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.
Häftad, Engelska, 2010
2 222 kr
Skickas inom 10-15 vardagar
This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.
Inbunden, Engelska, 2010
3 556 kr
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This volume contains an archival record of the NATO Advanced Study Institute on Microfluidics Based Microsystems – Fundamentals and App- cations held in Çe ?me-Izmir, Turkey, August 23–September 4, 2009. ASIs are intended to be high-level teaching activity in scientific and technical areas of current concern. In this volume, the reader may find interesting chapters and various microsystems fundamentals and applications. As the world becomes increasingly concerned with terrorism, early - spot detection of terrorist’s weapons, particularly bio-weapons agents such as bacteria and viruses are extremely important. NATO Public Diplomacy division, Science for Peace and Security section support research, Advanced Study Institutes and workshops related to security. Keeping this policy of NATO in mind, we made such a proposal on Microsystems for security. We are very happy that leading experts agreed to come and lecture in this important NATO ASI. We will see many examples that will show us Microfluidics usefulness for rapid diagnostics following a bioterrorism attack. For the applications in national security and anti-terrorism, microfluidic system technology must meet the challenges. To develop microsystems for security and to provide a comprehensive state-of-the-art assessment of the existing research and applications by treating the subject in considerable depth through lectures from eminent professionals in the field, through discussions and panel sessions are very beneficial for young scientists in the field.