The Mouse in Biomedical Research

Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.

• 1: Gross Anatomy2: Mouse Physiology3: Reproductive Biology of the Laboratory Mouse4: Endocrinology: Bone as a Target Tissue for Hormonal Regulation5: Hematology of the Laboratory Mouse6: Clinical Chemistry of the Laboratory MouseManagement, Techniques, and Husbandry7: Gnotobiotics8: Management and Design: Breeding Facilities9: Design and Management of Research Facilities for Mice10: Nutrition11: Health Delivery and Quality Assurance Programs for Mice12: Environmental and Equipment Monitoring13: Biomethodology and Surgical Techniques14: In-Vivo Whole-Body Imaging of the Laboratory MouseUse of Mice in Biomedical Research15: Behavioral Testing16: Cardiovascular Disease: Mouse Models of Atherosclerosis17: Convulsive Disorders18: Eye Research19: Genetic Analysis of Rodent Obesity and Diabetes20: Mouse Models in Aging Research21: Mouse Models of Inherited Human Neurodegenerative Disease22: Mouse Skin Ectodermal Organs23: Quality Control Testing of Biologics