Photobiomodulation in the Brain

Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and is a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. He was trained as a synthetic organic chemist and received his PhD from Trent University in England. His research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer, and heart disease and in low-level light therapy (LLLT) for wound healing, arthritis, traumatic brain injury and hair-regrowth. He directs a laboratory of around a sixteen post-doctoral fellows, visiting scientists and graduate students. His research program is supported by NIH, CDMRP, USAFOSR and CIMIT among other funding agencies. He has published 252 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents. He is Associate Editor for 7 journals, on the editorial board of a further 12 journals and serves on NIH Study Sections. For the past 9 years Dr Hamblin has chaired an annual conference at SPIE Photonics West entitled "Mechanisms for low level light therapy" and he has edited the 9 proceedings volumes together with four other major textbooks on PDT and photomedicine. He has several other book projects in progress at various stages of completion. In 2011 Dr Hamblin was honored by election as a Fellow of SPIE. Dr. Huang is an instructor at Harvard University. She completed her dermatology residency at Sun Yat-Sen University in Guangzhou, China and her postdoctoral work at the Wellman Center for Photomedicine in Massachusetts General Hospital and Harvard Medical School. She has years of experience in drug screening in vitro and in vivo cancer therapies and maintains research in clinical dermatology.

• Part I: Basic considerations and in vitro 1. Photobiomodulation therapy and the brain: an innovative tool for therapy and discovery Praveen R. Arany2. Theoretical neuroscience Marcelo Victor Pires de Sousa, Marucia Chacur, Daniel Oliveira Martins and Carlo Rondinoni3. Photobiomodulation of cultured primary neurons: role of cytochrome c oxidaseMargaret Wong-Riley and Huan Ling Liang4. Photobiomodulation on cultured cortical neuronsYing-Ying Huang and Michael R. Hamblin5. Safety and penetration of light into the brainErica B Wang, Ramanjot Kaur, Manuel Fierro, Evan Austin, Linda Ramball Jones and Jared Jagdeo6. Near-infrared photonic energy penetration—principles and practiceTheodore A. Henderson and Larry D. Morries7. Light sources and dosimetry for the brain and whole bodyJames D. Carroll8. Mechanisms of photobiomodulation in the brainMichael R. HamblinPart II: Studies in animal models 9. Transcranial photobiomodulation for stroke in animal modelsLuis De Taboada and Michael R. Hamblin10. Photobiomodulation in photothrombotic strokeLorelei Tucker, Luodan Yang, Yong Li and Quanguang Zhang11. Remote photobiomodulation as a neuroprotective intervention—harnessing the indirect effects of photobiomodulationLuke Gordon, Boaz Kim, Claudia Petrucco, Ji Yeon Kim, Patrick Benson, Jonathan Stone and Daniel M. Johnstone12. Photobiomodulation for traumatic brain injury in mouse modelsMichael R. Hamblin13. Photobiomodulation and mitochondria for traumatic brain injury in mouse modelsMei X. Wu and Michael R. Hamblin14. Photobiomodulation for depression in animal modelsFarzad Salehpour, Javad Mahmoudi, Saeed Sadigh-Eteghad and Paolo Cassano15. Transcranial photobiomodulation treats Alzheimer’s disease in amyloid-β protein precursor transgenic miceLuis De Taboada and Michael R. Hamblin16. Low-level laser therapy to the bone marrow: a new therapeutic approach to neurodegenerative diseasesAmir Oron and Uri Oron17. The experimental evidence for photobiomodulation-induced cellular and behavioral changes in animal models of Parkinson’s disease: a template for translation to patientsNabil El Massri and John Mitrofanis18. Effects of near-infrared low-level laser stimulation on neuronal excitabilityLjubica M. Konstantinovic and Sasa R. Filipovic19. Photobiomodulation for multiple sclerosis in animal modelsM.A. Tolentino and J.A. Lyons20. Hepatic encephalopathy and photobiomodulation: experimental models and clinical featuresNatalia Arias, Juan Dıaz Gonza´lez, Alberto Martın Pernıa and Jorge L Arias21. Photobiomodulation in animal models of retinal injury and diseaseJanis T. Eells22. Transcranial photobiomodulation therapy for pain: animal models, dosimetry, mechanisms, perspectivesMarcelo Victor Pires de Sousa, Nathali Cordeiro Pinto and Elisabeth Mateus YoshimuraPart III: Cinical studies 23. The challenge of effectively translating transcranial near-infrared laser therapy to treat acute ischemic strokePaul A. Lapchak24. Effects of photobiomodulation on traumatic brain injury: proposed clinical assessment Sherry Fox and Victoria Campbell25. Transcranial, red/near-infrared light-emitting diode therapy for chronic traumatic brain injury and poststroke aphasia: clinical studiesMargaret A. Naeser, Paula I. Martin, Michael D. Ho, Maxine H. Krengel, Yelena Bogdanova, Jeffrey A. Knight, Andrea Fedoruk, Michael R. Hamblin and Bang-Bon Koo26. Photobiomodulation as a potential therapeutic strategy for improving cognitive and functional outcomes in traumatic brain injuryThomas J. Covey, David W. Shucard, Melissa Meynadasy, Thomas Mang and Praveen R. Arany27. Advanced neuroimaging methods for assessment of low-level light therapySuk-tak Chan, Maria Gabriela Longo, Eva-Maria Ratai and Rajiv Gupta28. Treatment of traumatic brain injury with near-infrared lightLarry D. Morries and Theodore A. Henderson29. Photobiomodulation: a novel approach to treating Alzheimer’s diseaseLew Lim, Genane Loheswaran, Reza Zomorrodi, Anita Saltmarche and Linda Chao30. Electroencephalography as the diagnostic adjunct to transcranial photobiomodulation Reza Zomorrodi, Genane Loheswaran and Lew Lim31. Can photobiomodulation enhance brain function in older adults?Agnes S. Chan, Michael K. Yeung and Tsz L. Lee32. Noninvasive neurotherapeutic treatment of neurodegeneration: integrating photobiomodulation and neurofeedback trainingMarvin H. Berman, Trent Nichols, Jason Huang and Damir Nizamutdinov33. Transcranial photobiomodulation therapy: observations from four movement disorder patientsCatherine Hamilton, David Hamilton, Frank Nicklason and John Mitrofanis34. Cerebral blood flow in the elderly: impact of photobiomodulationAfonso Shiguemi Inoue Salgado, Francisco Jose´ Cidral-Filho,Daniel Fernandes Martins, Ivo I. Kerppers and Rodolfo Borges Parreira35. Transcranial photobiomodulation for major depressive and anxiety disorders and for posttraumatic stress disorderMarco Antonio Caldieraro and Paolo Cassano36. Action at a distance: laser acupuncture and the brainNicholas Alexander Wise37. Signature wounds of war: a case studyGeorge Louis Lindenfeld and George Rozelle38. Transcatheter intracerebral photobiomodulation in degenerative brain disorders: clinical studies (Part 1)Ivan V. Maksimovich39. Transcatheter intracerebral photobiomodulation in ischemic brain disorders: clinical studies (Part 2)Ivan V. Maksimovich40. Russian low level laser therapy techniques for brain disordersSergey V. Moskvin and Andrey V. Kochetkov41. Laser treatment of central nervous system injuries: an update and prospectsL. Longo42. Photobiomodulation treatment for brain disorders: posttraumatic stress disorder (PTSD) and dementiaRandy Lamartiniere, Rhett Bergeron, Ronald Aung-Din, Matthew Bennett, William Stephan and Louis Banas43. What we don’t know and what the future holdsMichael R. Hamblin