Microbiome, Immunity, Digestive Health and Nutrition

Dr. Bagchi is an academic, industry, and clinical-affairs leader in nutraceuticals, functional foods, toxicology, pharmacology, and nutrition science. He holds adjunct faculty appointments at Texas Southern University and Adelphi University, where he contributes to teaching in neurotoxicology and integrative neuroscience, and serves as Director of Innovation and Clinical Affairs at Dr. Herbs LLC. He previously held faculty and senior research leadership roles in pharmaceutical sciences, nutraceuticals, and scientific affairs. Dr. Bagchi has held leadership positions in professional organizations including the International Society of Nutraceuticals and Functional Foods, the American College of Nutrition, and the Institute of Food Technologists’ Nutraceuticals and Functional Foods Division. His work includes extensive peer-reviewed publications, edited books, and patents. He serves in advisory, peer-review, and editorial roles for scientific organizations and journals, with contributions spanning functional foods, nutrition, toxicology, oxidative stress, and biomedical research. Bernard William (Bill) Downs received his Bachelor of Science degree in 1975 from Pennsylvania State University. Downs simultaneously pursued his master’s degree and Ph.D. in Nutrition and Biochemistry at Immaculata University in Immaculata, PA; advanced degree not completed. He became Director of Therapeutic Nutrition for Morrison Family and Sports Medicine, Huntingdon Valley, PA from 1990 till 1996. Downs served as the Director of Technical Sales for InterHealth Nutraceuticals Inc., Benicia, CA from 1990 till 2003. He was the Director of Research and Development for Allied Nutraceutical Research, Blue Bell, PA, from 2003 till 2008. Downs served as the CEO of LifeGen Research from 2009 till 2013, Lederach, PA. Downs is Founder and CEO of Victory Nutrition International, Inc., a Research & Development Biotech Company, Lederach, PA. Downs is a member of the American Association for the Advancement of Science, the American College of Nutrition, and past member of the NY Academy of Sciences. He is on the editorial review board of the Journal of Reward Deficiency Syndrome. Downs has authored or co-authored 105 papers published in peer-reviewed journals, numerous chapters in texts and handbooks for clinicians and researchers, with patents-pending in nutraceutical biotechnology. Research publications have been on issues ranging from immunity, anemia and metabolic disorders to addictions, obsessions, compulsions, and personality disorders, among other Reward Deficiency Syndrome conditions.

"The book entitled Microbiome, Immunity, Digestive Health and Nutrition edited by Drs. Debasis Bagchi and Bernard Downs is comprehensive and well designed. It is very impressive, timely and informative, addressing complex and interrelated fields of study. It ties the interconnected and overlapping elements of the microbiome with the immune system and digestive health, and emphasizes the importance of nutrition in supporting and facilitating these key physiological mechanisms. The chapters are well written, and address specific topics related to the overall scope of the book. This book will certainly be very impactful, and will be exceedingly useful to scholars and scientists at all levels of background in these areas." --Sidney J. Stohs, Ph.D., FACN, CNSE, ATS, FAPHA, FASAHP, Dean Emeritus, Creighton University medical Center

• I. PrefaceFrom the Editor's DeskII. Microbiome and Human Health: An Introduction1. Oral Microbiome: A Gateway to Human Health2. Influence of Microbiome in Shaping the Newborn Immune System: An Overview3. Impact of Gut Bacteria on Human Health and Diseases4. Individual Microbiota Correction and Human Health: Programing and Reprogramming of Systemic and Local Immune ResponseIII. Microbiome and Digestive Health5. The Etiology of Gut Dysbiosis and its Role in Chronic Disease6. Role of Microbiome in the Function and Diseases of the Digestive SystemIV. Microbiome and Metabolic Syndrome7. Beneficial Role of Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health8. The Role of the Intestinal Microbiota in Weight Loss9. Role of Microbial Metabolites in Cardiovascular and Human Health10. Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health: An Overview11. Potential Role of Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health12. Restoring Gut Biome Balance for Weight Loss: Clinical applications13. Harnessing Gut Friendly Microbiomes to Combat Metabolic Syndrome14. The Effect of Resveratrol-Mediated Gut Microbiota Remodeling on Metabolic DisordersV. Microbiome and Immune Health15. Microbiome, Immunity, Anaerobism, and Inflammatory Conditions: A Multifaceted Systems Biology Intervention16. Preclinical Data Supports the Strong Specificity and Advertised Ability to Mitigate Immune Reactions at Mucosal SitesVI. Microbiome and Cognitive Health17. Achieving Dopamine Homeostasis to Combat Brain-Gut Functional Impairment: Behavioral and Neurogenetic Correlates of Reward Deficiency Syndrome (RDS) 18. Influence of Gut Microbial Flora in Body’s Serotonin Turnover and Its Associated Diseases19. The Connection Between Diet, Gut Microbes and Cognitive Decline20. Role of the Gut Microbiome in Rett SyndromeVII. Microbiome, Dermal Health and Wound Healing21. Skin Microbiota and its Role in Health and Disease with an Emphasis in Chronic Wound Development and Wound HealingVIII. Microbiome and Cancer22. Healthy Gut Microbiome in the Prevention of Colorectal CancerIX. Microbiome, Arthritis and Multiple Sclerosis23. Regulatory Roles of the Microbiome in Arthritis, Fibromyalgia, and Multiple SclerosisX. Environmental Pollutants and Gut Microbiome24. Microplastic Exposure and Gut MicrobiomeXI. Molecular and Immunological Mechanisms Associated with Healthy Gut Microbiome Functions25. Role of the Gut Microbiome and Probiotics for Tuberculosis Prevention and Management26. Lactic Acid Bacteria-Based Beverages in Promotion of Gastrointestinal Health 27. Prospective role of prebiotics and probiotics on gut immunity28. Gut Brain Communication: A novel application of Probiotics29. Beneficial Effects of Flaxseed on Gut Microbiota30. Dietary Flavonoids and Gut Microbiota31. Role of Mushroom Polysaccharides in Improving Gut health and Prevent Associated DiseasesXII. Microbiome and Immunomodulatory Peptides32. Food derived immunomodulatory peptides: Science to applicationsXIII. Study Design and Statistical Interpretation33. Clinical Intervention Study Design and Statistical Methodology: Statistical Approaches for Pre–Post StudiesXIV. Commentary from the Editor's Desk34. Conclusion and Editor's Commentary