Dr. Lara Milane is Assistant Teaching Professor in Biotechnology at the Bouvé College of Health Sciences at Northeastern University. She is interested in Mitochondrial Medicine. She is working on developing nanomedicines for a range of diseases (cancer, neurodegenerative disease, aging) that manipulate mitochondria for therapeutic outcomes. Dr. Milane was trained as a National Cancer Institute/ National Science Foundation Nanomedicine Fellow at Northeastern University, Boston, MA. Dr. Milane is an intuitive cancer biologist with research interests in developing translational nanomedicines that exploit the hallmarks of cancer. Mansoor M. Amiji is the Distinguished Professor and Chairman of the Department of Pharmaceutical Sciences at the Bouvé College of Health Sciences at Northeastern University. Dr. Amiji has edited a number of books and is a frequently published author. His research focuses on the synthesis of novel polymeric materials for medical and pharmaceutical applications, drug delivery systems and nanomedical technologies, and his contributions in research advising, grant reviews for various organizations and editorial work for journals are invaluable.

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• 1. Introduction2. Biological Targets3. Getting Through – The Challenges and Approaches to Overcoming Biological Barriers4. Making a Connection – Contact Point and Mechanism of Internalization Significance5. Tunneling Nanotubes6. Extracellular Vesicles7. The Immune and Non-Immune Interface8. Crosstalk of Different Forms of Intercellular Communication9. Crosstalk of Different Forms of Intercellular Communication in Cancer10. Crosstalk of Different Forms of Intercellular Communication in Neurological Disease11. Crosstalk of Different Forms of Intercellular Communication in Metabolic Disease12. Crosstalk of Different Forms of Intercellular Communication in Inflammatory and Immune Disease13. Implications of Mitochondrial Exchange14. Conclusion