Bruce R. Korf is Wayne H. and Sara Crews Finley Chair in Medical Genetics, Professor and Chair, Department of Genetics, and Director, Heflin Center for Genomic Sciences, at the University of Alabama at Birmingham. Mira B. Irons is Park Gerald Chair in Genetics and Associate Chief, Division of Genetics, at the Children's Hospital Boston, and Associate Professor of Pediatrics at Harvard Medical School.

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• Preface viiHow to get the best out of your textbook viiiPART ONE: BASIC PRINCIPLES OF HUMAN GENETICS 11 DNA Structure and Function 32 Genetic Variation 203 Patterns of Inheritance 384 The Human Genome 645 Multifactorial Inheritance 876 Cell Division and Chromosomes 1007 Population Genetics 1258 Cancer Genetics 137PART TWO: GENETICS AND GENOMICS IN MEDICAL PRACTICE 1559 Chromosome Translocation 15710 Molecular Diagnosis 17111 Newborn Screening 18212 Developmental Genetics 19413 Carrier Screening 20314 Genetic Risk Assessment 21315 Genetic Testing for Risk of Cancer 22216 Pharmacogenetics 23017 Treatment of Genetic Disorders 239Answers to Review Questions 248Glossary 253Index 262

Bruce R. Korf is Wayne H. and Sara Crews Finley Chair in Medical Genetics, Professor and Chair, Department of Genetics, and Director, Heflin Center for Genomic Sciences, at the University of Alabama at Birmingham. Mira B. Irons is Park Gerald Chair in Genetics and Associate Chief, Division of Genetics, at the Children's Hospital Boston, and Associate Professor of Pediatrics at Harvard Medical School.

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• Preface viiHow to get the best out of your textbook viiiPART ONE: BASIC PRINCIPLES OF HUMAN GENETICS 11 DNA Structure and Function 32 Genetic Variation 203 Patterns of Inheritance 384 The Human Genome 645 Multifactorial Inheritance 876 Cell Division and Chromosomes 1007 Population Genetics 1258 Cancer Genetics 137PART TWO: GENETICS AND GENOMICS IN MEDICAL PRACTICE 1559 Chromosome Translocation 15710 Molecular Diagnosis 17111 Newborn Screening 18212 Developmental Genetics 19413 Carrier Screening 20314 Genetic Risk Assessment 21315 Genetic Testing for Risk of Cancer 22216 Pharmacogenetics 23017 Treatment of Genetic Disorders 239Answers to Review Questions 248Glossary 253Index 262

Bruce R. Korf is Wayne H. and Sara Crews Finley Chair in Medical Genetics, Professor and Chair, Department of Genetics, and Director, Heflin Center for Genomic Sciences, at the University of Alabama at Birmingham. Mira B. Irons is Park Gerald Chair in Genetics and Associate Chief, Division of Genetics, at the Children's Hospital Boston, and Associate Professor of Pediatrics at Harvard Medical School.

Select Guide Rating

• Preface viiHow to get the best out of your textbook viiiPART ONE: BASIC PRINCIPLES OF HUMAN GENETICS 11 DNA Structure and Function 32 Genetic Variation 203 Patterns of Inheritance 384 The Human Genome 645 Multifactorial Inheritance 876 Cell Division and Chromosomes 1007 Population Genetics 1258 Cancer Genetics 137PART TWO: GENETICS AND GENOMICS IN MEDICAL PRACTICE 1559 Chromosome Translocation 15710 Molecular Diagnosis 17111 Newborn Screening 18212 Developmental Genetics 19413 Carrier Screening 20314 Genetic Risk Assessment 21315 Genetic Testing for Risk of Cancer 22216 Pharmacogenetics 23017 Treatment of Genetic Disorders 239Answers to Review Questions 248Glossary 253Index 262