Defining Optimal Immunotherapies for Type 1 Diabetes

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• 1. Michael Rutter Introduction: whither gene–environment interactions?2. Rudolf UherGene–environment interaction: overcoming methodological challengesDiscussion3. Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D’AmatoGene–environment interaction and behavioural disorders: a developmental perspective based on endophenotypesDiscussion4. Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. MartinUse of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response TheoryDiscussionAppendixGeneral discussion I5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. HartmanRole of gene–stress interactions in gene-finding studiesDiscussion6. Kenneth A. DodgePractice and public policy in the era of gene–environment interactionsDiscussion7. Kristi B. Adamo and Frédérique TessonGene–environment interaction and the metabolic syndromeDiscussionGeneral discussion II8. Stephen P. Robertson and Richie PoultonLongitudinal studies of gene–environment interaction in common diseases—good value for money?Discussion9. Kee-Seng ChiaGene–environment interactions in breast cancerDiscussion10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu LuUnbiased forward genetics and systems biology approaches to understanding how gene–environment interactions work to predict susceptibility and outcomes of infectionsDiscussion11. Steven R. Kleeberger and Hye-Youn ChoGene–environment interactions in environmental lung diseasesDiscussionGeneral discussion III12. Fernando D. MartinezGene–environment interaction in complex diseases: asthma as an illustrative caseDiscussion13. Michael RutterConclusions: taking stock and looking aheadGlossaryIndex of contributorsSubject index