Fertility, Reproduction, and Treatment

George Anifandis is a Professor of Embryology in the Faculty of Medicine at the University of Thessaly in Greece. He is the Director of the Histology and Embryology Department, Laboratory Director of the IVF Unit of the Obstetrics and Gynaecology Department of the University Hospital of Larisa in Greece. He has published more than ninety papers in high-impact factor journals related to sperm and embryo quality and serves as an Associate Editor in more than three international journals, along with his position on the Editorial Board of Systems Biology in Reproductive Medicine.Stephen A. Krawetz is the Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, C.S. Mott Center for Human Growth and Development, Wayne State University. He is a Fellow of the American Association for the Advancement of Science and the founding Editor-in-Chief of Systems Biology in Reproductive Medicine. His group established that the fitness of the paternal contribution reflects the relative diversity of sperm RNAs as they respond to the environment. They provide a personalized timestamp of the physical and reproductive health of the male.Peter Sutovsky is Professor of Animal Science at the University of Missouri College of Agriculture, Food and Natural Resources and Professor of Obstetrics, Gynecology and Women's Health at the University of Missouri School of Medicine. His research focuses on mammalian gametogenesis, fertilization, and embryonic development, with emphasis on the ubiquitin-proteasome system. He is a Founding Associate Editor of Systems Biology in Reproductive Medicine, a Fellow of the American Association for the Advancement of Science and a Distinguished Fellow of The Society for the Study of Reproduction.

• Introduction 1. A concise overview of mammalian spermatogenesis 2. Molecular mechanisms of folliculogenesis and oogenesis 3. Fertilization and oocyte activation: overview, updates, and novel hypotheses from a molecular perspective 4. Early embryo development: the current perspective in molecular evaluation and clinical status 5. Human placentation: foundations and implications for reproductive endocrinology and infertility 6. Regulation of the brain-placental axis, and its relevance to the health and disease of the offspring 7. Overview of Infertility 8. Male infertility 9. Insight into the complexity of male infertility: a multi-omics review 10. The biology and clinical aspects of female infertility 11. Reproductive microbiota in humans: characterization and role in infertility 12. The genetic basis of male and female infertility 13. Ovarian stimulation protocols in fresh cycles and in elective freeze-all cycles 14. In vitro fertilization, intracytoplasmic sperm injection, in vitro maturation, and embryo culture 15. In vitro maturation of oocytes (IVM): historical landmarks, current status and future perspectives 16. Cryopreservation in human reproductive medicine 17. Navigating male infertility through testicular biopsy: outcomes, predictive parameters, and surgical innovation 18. Viruses and assisted reproductive technologies (ART) 19. Bioethics in assisted reproduction and embryology 20. Navigating the practical challenges and ethical dilemmas of surplus cryopreserved human embryos 21. Future directions in infertility research: the role of generative AI and large language models