Universities are undergoing profound transformations as digital technologies reshape their missions, governance, and organizational culture. This book provides a comprehensive analysis of these changes, offering an integrative framework to understand digital transformation as a systemic shift in higher education. Grounded in post-pandemic case studies from Europe and Asia, it examines how digital tools, institutional strategies, and leadership practices intersect to drive innovation while addressing challenges such as equity, academic integrity, and organizational resistance. Readers will gain valuable insights from the “new academic wave” framework, which reconfigures traditional higher education theories for the digital era. Key topics include data-driven governance, inclusive digital pedagogy, cybersecurity, faculty online safety, and the evolving roles of leadership and culture. The book combines rigorous research with practical guidance, featuring comparative case studies, actionable strategies, and critical reflections to support both scholarly inquiry and institutional decision-making. This monograph is essential for higher education researchers, university leaders, policymakers, and educational technology professionals. Its global perspective, human-centered approach, and balance of theory and practice ensure relevance for diverse institutional contexts. By bridging academic analysis with practical solutions, it equips readers to navigate the complexities of digital transformation in higher education.