Artificial intelligence represents perhaps the most consequential technological shift for political science in a generation, with the potential to reshape most domains of politics and political inquiry. Produced by the American Political Science Association's Presidential Task Force on AI, Politics, and Political Science, this volume offers the first comprehensive, discipline-wide assessment of AI's effects. Drawing on contributions from over 60 leading scholars, it examines how AI is transforming political campaigns, election administration, information ecosystems, public opinion research, geopolitics and national security, policymaking, political theory, economic inequality, racial and gender politics, and political science pedagogy and methods. Each chapter delivers rigorous empirical assessment alongside implications for researchers, practitioners, and policymakers. A central argument runs throughout: AI's political impact is shaped not by technological capability alone but by the regulatory frameworks, institutional contexts, and political choices governing its deployment. This title is also available as Open Access on Cambridge Core.