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    Role of Flavonoids in Chronic Metabolic Diseases

    From Bench to Clinic

    AvNeeraj Mishra,Sumel Ashique

    Inbunden, Engelska, 2024

    2 723 kr

    Beställningsvara. Skickas inom 5-8 vardagar. Fri frakt över 249 kr.

    Beskrivning

    This comprehensive volume covers the entire field of flavonoids by explaining their complex functions in reducing chronic metabolic illnesses, from the early stages of laboratory research to the development of therapeutic uses. Flavonoids are plant-based substances proven to have potential medical benefits in managing chronic metabolic disorders. This book explores concepts in laboratory research and therapeutic capabilities to enhance awareness of flavonoids in a medical context. The book begins with a thorough examination of the basic biochemical and molecular processes that underlie long-term metabolic disorders. It looks into these bioactive substances, from their natural origins to the synthesis of innovative derivatives. Analyzing both lab research and preclinical trials critically, it provides a solid basis for understanding the exciting opportunities flavonoids bring in treating metabolic diseases. The scope of this work extends beyond theoretical domains into clinical environments. It closes the gap between bench-side findings and bedside applications by revealing the translational potential of flavonoids. It is possible to understand the practical implications and future directions of flavonoid-based therapeutics through the synthesis of evidence-based clinical studies, therapeutic approaches, and possible healthcare issues. Readers will find the book: contains cutting-edge insights into metabolic disease research and delves into recent discoveries on the molecular mechanisms of flavonoids; facilitates a viewpoint into the findings of practical clinical implementations and the progression of flavonoid investigations from controlled experimental environments to prospective therapeutic interventions;explores the scientific effects of flavonoids on chronic metabolic disorders;presents evidence from human trials and epidemiological research on flavonoid clinical processes;encompasses various aspects of preventive measures for managing widespread metabolic diseases, containing dietary recommendations, lifestyle interventions, and the potential involvement of flavonoids;offers a comprehensive guide on how to effectively utilize flavonoids for therapeutic purposes. Audience This book is intended for researchers, scientists, clinicians/physicians, and public health professionals who work in pharmacology settings. The book is a vital tool for clinicians, nutritionists, and other healthcare professionals who are concerned about cutting-edge methods for dietary guidelines to gain an understanding of flavonoids and long-term metabolic disorders.

    Produktinformation

    • Utgivningsdatum:2024-09-04
    • Vikt:1 134 g
    • Format:Inbunden
    • Språk:Engelska
    • Antal sidor:624
    • Förlag:John Wiley & Sons Inc
    • ISBN:9781394238040

    Utforska kategorier

    • Övrig teknik och tillämpad vetenskap inom Naturvetenskap och teknik
    • Teknik: allmänt inom Naturvetenskap och teknik
    • Medicinsk utrustning och medicinska tekniker inom Medicin

    Mer om författaren

    Neeraj Mishra is a professor at the Amity Institute of Pharmacy, Uttar Pradesh, India. He has published more than 100 articles on novel drug delivery systems, localized drug delivery, and targeted and controlled drug delivery on nanocarriers in international and national journals, as well as 15 books. He has been granted three international and three Indian patents. Sumel Ashique is an assistant professor at the Bengal College of Pharmaceutical Sciences & Research, West Bengal, India. Research interests include drug delivery, nanotechnology, and target treatment strategies. Ashique has published more than 60 articles in international and national-reputed journals and has been granted four patents from India and Australia. B.H. Jaswanth Gowda is a senior research fellow at Yenopya (deemed to be a university), Mangalore, India. His research primarily focuses on developing varieties of nano- and micro-based transdermal and ocular drug delivery systems, including microneedles, for the treatment of various disease conditions. He has authored 40+ research and review articles and book chapters. Arshad Farid is an assistant professor at the Gomal Center of Biochemistry and Biotechnology, Gomal University, Pakistan. He has more than 90 international and national publications and 15 international patents. Ashish Garg is an assistant professor in the Department of P.G. Studies and Research in Chemistry and Pharmacy, Rani Durgavati, Jabalpur, India. He has published over 80 articles in national and international journals, authored 15 book chapters, and edited 6 books. Garg has been granted three international patents and published three Indian patents.

    Innehållsförteckning

    • Preface xxv1 Exploring the Therapeutic Power of Flavonoids on Chronic Disease: Unraveling the Mechanisms of Action Especially by Following MAPKs/NF-KB Signaling Pathways 1Habab Ali Ahmad, Fazal Wahab, Mujib Ullah and Muhammad Imran Khan1.1 Introduction 21.2 Chronic Diseases and Inflammation 71.3 Interplay between Flavonoids and Inflammatory Mediators 121.4 Estrogenic Activities of Flavonoids 121.5 Chronic Diseases and Role of Flavonoids 141.6 Flavonoids’ Role in Neurodegenerative Disorders 241.7 Mechanisms of Action 251.8 In Vitro Experimental Approaches 271.9 In Vitro Studies on Flavonoid-Mediated Signaling Modulation 291.10 Animal Models and Preclinical Investigations 301.11 Animal Models and Methodologies 301.12 Human Clinical Trials: Efficacy and Safety of Flavonoid Interventions 351.13 Mechanism of Action 361.14 Future Research Directions for Improved Flavonoids Use 391.15 Conclusion 412 Structure--Activity Relationship Between Flavonoids and Chronic Metabolic Diseases 51Bhavesh Deore and Richa Vartak2.1 Introduction 522.2 Chemistry of Flavonoids Associated with Metabolic Disorders 522.3 Current Advancements 612.4 Conclusion 623 Dietary Sources, Classification, Biosynthesis, and Mechanism of Action of Flavonoids in Combating Oxidative Stress 67Muhammad Sirab Khan, Sadaf Khan, Nida Khan and Amir Sada Khan3.1 Introduction 683.2 Dietary Source 683.3 Classification of Flavonoids 703.4 Biosynthesis of Flavonoids 773.5 Mechanism of Flavonoids in Combating Oxidative Stress Against Chronic Diseases 824 Role of Flavonoids and Probiotics for Maintaining Healthy Gut Microbiota in Response to Chronic Metabolic Diseases 115Habab Ali Ahmad, Neelum Gul Qazi, Nasir Jalal and Muhammad Imran Khan4.1 Introduction 1164.2 Interaction with Gut Microbiota 1194.3 Role of Flavonoids in the Gut Microbiota 1194.4 Overview of Probiotics 1274.5 Role of Probiotics in the Gut Microbiota 1324.6 Flavonoids and Gut Barrier Protection 1344.7 Implications for Health 1354.8 Immune System Modulation 1354.9 Production of Bioactive Metabolites Beneficial for Gut Health 1374.10 Synergistic Effects of Flavonoids and Probiotics on Gut Health 1394.11 Potential in Alleviating Symptoms of Chronic Metabolic Diseases 1424.12 Potential Therapeutic Strategies Using Flavonoids and Probiotics 1454.13 Current Limitations and Challenges 1474.14 Potential Side Effects and Interactions 1484.15 Future Directions 1514.16 Conclusion 1545 Correlation Between Gut Microbiota and Chronic Metabolic Diseases 161Aneela Nawaz, Sabeena Zafar, Muqaddas Shahzadi, Mehmoona Sharif, Umme Habiba Saeeda, Nauman Ahmed Khalid and Samiullah Khan5.1 Introduction 1625.2 Normal Gut Microbiota 1645.3 Role of Gut Microbiota 1655.4 The GIT’s Structure and Function 1685.5 Outside of GIT 1705.6 Nutrition and Metabolism 1715.7 Human Gut Microbiota Homeostasis and Its Roles in Intestinal Health 1725.8 Variables Influencing Microbial Homeostatic Balance 1735.9 Metabolic Disorders Associated with Dysbiosis of Gut Microbiota 1755.10 Treating Gut Microbiome Dysbiosis 1785.11 Conclusion 1816 Impact of Dietary Flavonoid Metabolism on Gut Microbiome: A Key Therapeutic Approach for the Management of Type 2 Diabetes Mellitus 189Mehmoona Sharif, Mohammad Ejaz, Aneela Nawaz, Umme Habiba Saeeda, Shayan Naeem and Samiullah Khan6.1 Introduction 1906.2 Food-Based Flavonoids 1926.3 Flavonoid Metabolism within the Gut 1936.4 Flavonoids and Gut Microbiota 2006.5 The Influence of Flavonoids on Gut Microbiota 2006.6 Gut Microbiota and T2DM 2086.7 Mechanism of Action of Flavonoids on Type 2 Diabetes Mellitus 2086.8 Impact of Flavonoids on Gut Microflora Against Diabetes Complication 2146.9 Conclusion 2176.10 Future Prospects 2187 Impact of Dietary Plant Flavonoids on Obesity and Autophagy 227Phool Chandra, Zeeshan Ali, Nishat Fatma and Neetu Sachan7.1 Introduction 2287.2 The Role of Autophagy and Obesity 2307.3 Dietary Flavonoids: A Diverse Class of Plant Compounds 2327.4 Mechanisms of Dietary Plant Flavonoids in Obesity and Autophagy 2347.5 Flavonoids and Obesity-Associated Metabolic Disorders 2417.6 Biosynthesis and Bioavailability of Dietary Plant Flavonoid 2467.7 Conclusion 2478 Flavonoids and Nanotechnology in Insulin Resistance Diabetic Complications 259Sanjesh Kumar, Mansi Singh, Pooja S. Murkute, Ananya Chakraborty, Arshad Farid, Hafiza Sehrish Kiani, Farzad Taghizadeh-Hesary, Mithun Bhowmick and Sumel Ashique8.1 Introduction 2608.2 Insulin Resistance Diabetic Complications 2618.3 Classification of Flavonoids 2738.4 Current Treatment Approaches for Insulin Resistance Diabetic Complications 2848.5 Types and Mechanisms of Nanocarrier Encapsulated Flavonoids in Insulin Resistance Diabetic Complications 2938.6 Advantages and Limitations of Nanotechnology in Diabetic Complications 3018.7 Toxicity of Flavonoids 3068.8 Conclusion 3099 The Effect and Mechanisms of Flavonoids on Inflammation and Chronic Metabolic Diseases 317Sagnik Nag, Janardhan Pallavi, Ushasi Das Bose, Sana Jalili, Nayanika Pramanik, Sourav Mohanto and Mohammed Gulzar Ahmed9.1 Introduction 3189.2 Overview of Flavonoid Biosynthesis and Biomedical Significance 3229.3 Flavonoids as Anti-Inflammatory Agent 3269.4 Flavonoids against Chronic Inflammatory Metabolic Disorders 3289.5 Challenges to Using Flavonoid as a Therapeutic Agent 3369.6 Future Perspectives and Conclusion 33810 Flavonoids and Their Metabolites: Impact on Gut Microbiota in Connection with Chronic Metabolic Diseases 347Priyanka Chakraborty, Koyel Kar, Sailee Chowdhury and Kamalika Mazumder10.1 Introduction 34810.2 Classification of Flavonoids 34910.3 Effects of Flavonoids and Their Metabolites on Gut Microbiota 35210.4 Metabolic Effects of Gut Microbiota on Flavonoids and Their Metabolites 35710.5 Flavonoids, Microbiota, and Metabolic Diseases 36310.6 Future Prospect 36710.7 Conclusion 36811 Polyphenol-Encapsulated Nanoparticles for the Treatment of Chronic Metabolic Diseases 375Popat Mohite, Abhijeet Puri, Deepak Bharati and Sudarshan Singh11.1 Introduction 37611.2 Nanodrug Delivery System 37811.3 Medicinal Plant Extract: Polyphenols 38411.4 Nanoencapsulation of Polyphenolics 38811.5 Plant Extracted Nano-Systems for Prevention and Treatment of Different Metabolic Disorders 39111.6 Delivery of Polyphenols to the Targets 40111.7 Polyphenol Activity and Chemical Structure Correlation 40211.8 Challenging Issues in Applications of Polyphenol-Encapsulated Nanoparticles 40411.9 Conclusion 40512 Role of Flavonoids in ROS-Mediated Cardiovascular Disorders 417Santenna Chenchula, Kuttiappan Anitha, Ashish Garg, Sumel Ashique, Mohan Krishna Ghanta and Neeraj Mishra12.1 Introduction: General Flavonoids and Cardiovascular Disorders 41812.2 Role of Flavonoids in Different Ailments 41912.3 Pathophysiology of Cardiovascular Disorders and Oxidative Stress Contribution 42512.4 Mechanism of Flavonoids in ROS-Mediated Cardiovascular Disorders 43012.5 Strategies of Antioxidant Therapy in CV Disorders 43912.6 Safety and Toxicity Concerns Associated with the Consumption of Flavonoids in the Human Body 44412.7 Conclusion and Future Prospects 44513 Advancement of Nanoengineered Flavonoids for Chronic Metabolic Diseases 459Himanshu Sharma, Amit Anand, Praveen Halagali, Aparna Inamdar, Rashmi Pathak, Farzad Taghizadeh-Hesary and Sumel Ashique13.1 Introduction 46013.2 Flavonoids: Nature Therapeutic Compounds 46513.3 Nanoengineering Strategies for Flavonoid Delivery 47013.4 Optimization of Nanoengineered Flavonoids 47813.5 Enhanced Bioavailability and Stability of Flavonoids 48013.6 Nanoengineered Flavonoids for Chronic Metabolic Diseases 48313.7 Preclinical, Clinical Studies, and Recent Progress 49113.8 Challenges 49113.9 Conclusion and Future Prospective 49114 Flavonoid Intake and Risk of Toxicity in Chronic Metabolic Disease 511Sanzia Mehjabin, Md. Khokon Miah Akanda, Nazia Hoque, A. H. M. Nazmul Hasan, G. M. Masud Parvez and Ashik Mosaddik14.1 Introduction 51214.2 Dose and Intake 51414.3 Delivery System 51414.4 How to Develop the Disease by Taking Flavonoids in Excessive Amounts 51614.5 Risk of Toxicity 51714.6 Toxicity Measurement 52414.7 Remedies 52614.8 Conclusion 52815 Molecular Mechanisms of Flavonoids in Chronic Metabolic Diseases and Path to Clinical Trials 535Mahnoor Zafar, Neelum Gul Qazi, Waqas Nawaz and Muhammad Imran Khan15.1 Introduction 53615.2 The Complex Interplay of Flavonoids and Metabolic Pathways 53715.3 Angiogenesis, Vascular Health, and Hepatic Enzyme Modulation 54015.4 Neurohormonal Mechanisms 54215.5 Inhibition of Advanced Glycation End-Products 54415.6 Fatty Acid Synthase, Lipid Metabolism, and Flavonoids 54515.7 Clinical Studies (Animal and Human Studies) 54815.8 Dose Delivery Systems 55515.9 Barriers and Challenges in Clinical Trials 55915.10 Improving Study Design and Use of Advanced Technology for Data Compilation 56216 Flavonoid Associated with Preclinical and Clinical Trials Involved in Insulin Resistance/Hyperglycemia, Obesity, Liver Intoxication, Aging, and Cardiovascular Diseases 571Junaid Qayum, Abida Bibi, Gagan Preet and Arshad Farid16.1 Introduction to Flavonoids 57216.2 Obesity and Treatment via Flavonoids 57516.3 Risk of Liver Intoxication and the Protective Role of Flavonoids 57916.4 Flavonoids and Cardiovascular Diseases: Role of NF-kB Signaling Pathway 58116.5 Conclusion 584References 584Index 591