Eldridge, J. Charles; Stevens, James T.

"This is an excellent review of the effects of toxic substances on endocrine axes in both humans and wildlife.... The ambitious goals of covering the expanse of molecular toxicology and regulatory action are met by the book's diverse chapters......Because of the array of authors, the book serves as an excellent introduction to many areas related to endocrine toxicology....... The book does an excellent job of covering the topics in endocrine disruption that have become increasingly relevant over the last three decades. The classic mechanisms of endocrine disruption, namely alterations in estrogen and androgen signaling, are covered in two excellent chapters....As a whole, this book offers an excellent review of the effects of toxins on endocrine physiology with a particular strength in its coverage of government programs for monitoring these effects and the subsequent implications for regulatory policy. Because of the burgeoning knowledge in this area, this update is certainly appreciated, and subsequent editions will be welcome as our knowledge of endocrine disruption expands to other areas of endocrine physiology."Weighted Numerical Score: 94 - 4 Stars![DOODY'S NOTES][REVIEWER'S EXPERT OPINION]Robert Michael Sargis, M.D., Ph.D.(University of Chicago Medical Center)

• Regulation of Endocrine Disruptive Chemicals in the United States. Pursuit of Endocrine Disruptors in Europe - the OECD Component. Impact of Endocrine Disruptor Policies and Regulations. The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. The Hypothalamic-Pituitary-Gonadal Axis in Birds. The Hypothalamic-Pituitary-Gonadal Axis in Mammals. Comparing and Contrasting the Hypothalamic-Pituitary-Gonadal Axis in Different Vertebrate Classes. Male Reproductive Endpoints and the Rodent Hershberger Assay. Review of Bisphenol A by the National Toxicology Program. Pubertal Screening Assays in Rodents. Endocrine Disruption at Neuroendocrine and Neurotransmitter Sites. Endocrine Disruptor Interaction with Estrogen Receptors. Analysis of Endocrine Disruptors with Estrogen Reporter Systems. Time Dependent Embryotoxicity of the Endogenous Luteolysin, Prostaglandin F2alpha, in Ruminants. Actions of Endocrine Disruptors on the Thyroid Axis. Endocrine Disruption of Hormone Storage and Transport. Metal Toxicity in Mammalian Reproduction. Structure-Activity Modeling of Endocrine Disruptors. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Biological Activity of Endocrine Disruptors in Aquatic Systems. Impact of Endocrine Disruptors on the Water Industry.

Eldridge, J. Charles; Stevens, James T.

"This is an excellent review of the effects of toxic substances on endocrine axes in both humans and wildlife.... The ambitious goals of covering the expanse of molecular toxicology and regulatory action are met by the book's diverse chapters......Because of the array of authors, the book serves as an excellent introduction to many areas related to endocrine toxicology....... The book does an excellent job of covering the topics in endocrine disruption that have become increasingly relevant over the last three decades. The classic mechanisms of endocrine disruption, namely alterations in estrogen and androgen signaling, are covered in two excellent chapters....As a whole, this book offers an excellent review of the effects of toxins on endocrine physiology with a particular strength in its coverage of government programs for monitoring these effects and the subsequent implications for regulatory policy. Because of the burgeoning knowledge in this area, this update is certainly appreciated, and subsequent editions will be welcome as our knowledge of endocrine disruption expands to other areas of endocrine physiology."Weighted Numerical Score: 94 - 4 Stars![DOODY'S NOTES][REVIEWER'S EXPERT OPINION]Robert Michael Sargis, M.D., Ph.D.(University of Chicago Medical Center)

• Regulation of Endocrine Disruptive Chemicals in the United States. Pursuit of Endocrine Disruptors in Europe - the OECD Component. Impact of Endocrine Disruptor Policies and Regulations. The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. The Hypothalamic-Pituitary-Gonadal Axis in Birds. The Hypothalamic-Pituitary-Gonadal Axis in Mammals. Comparing and Contrasting the Hypothalamic-Pituitary-Gonadal Axis in Different Vertebrate Classes. Male Reproductive Endpoints and the Rodent Hershberger Assay. Review of Bisphenol A by the National Toxicology Program. Pubertal Screening Assays in Rodents. Endocrine Disruption at Neuroendocrine and Neurotransmitter Sites. Endocrine Disruptor Interaction with Estrogen Receptors. Analysis of Endocrine Disruptors with Estrogen Reporter Systems. Time Dependent Embryotoxicity of the Endogenous Luteolysin, Prostaglandin F2alpha, in Ruminants. Actions of Endocrine Disruptors on the Thyroid Axis. Endocrine Disruption of Hormone Storage and Transport. Metal Toxicity in Mammalian Reproduction. Structure-Activity Modeling of Endocrine Disruptors. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Biological Activity of Endocrine Disruptors in Aquatic Systems. Impact of Endocrine Disruptors on the Water Industry.

Eldridge, J. Charles; Stevens, James T.

"This is an excellent review of the effects of toxic substances on endocrine axes in both humans and wildlife.... The ambitious goals of covering the expanse of molecular toxicology and regulatory action are met by the book's diverse chapters......Because of the array of authors, the book serves as an excellent introduction to many areas related to endocrine toxicology....... The book does an excellent job of covering the topics in endocrine disruption that have become increasingly relevant over the last three decades. The classic mechanisms of endocrine disruption, namely alterations in estrogen and androgen signaling, are covered in two excellent chapters....As a whole, this book offers an excellent review of the effects of toxins on endocrine physiology with a particular strength in its coverage of government programs for monitoring these effects and the subsequent implications for regulatory policy. Because of the burgeoning knowledge in this area, this update is certainly appreciated, and subsequent editions will be welcome as our knowledge of endocrine disruption expands to other areas of endocrine physiology."Weighted Numerical Score: 94 - 4 Stars![DOODY'S NOTES][REVIEWER'S EXPERT OPINION]Robert Michael Sargis, M.D., Ph.D.(University of Chicago Medical Center)

• Regulation of Endocrine Disruptive Chemicals in the United States. Pursuit of Endocrine Disruptors in Europe - the OECD Component. Impact of Endocrine Disruptor Policies and Regulations. The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. The Hypothalamic-Pituitary-Gonadal Axis in Birds. The Hypothalamic-Pituitary-Gonadal Axis in Mammals. Comparing and Contrasting the Hypothalamic-Pituitary-Gonadal Axis in Different Vertebrate Classes. Male Reproductive Endpoints and the Rodent Hershberger Assay. Review of Bisphenol A by the National Toxicology Program. Pubertal Screening Assays in Rodents. Endocrine Disruption at Neuroendocrine and Neurotransmitter Sites. Endocrine Disruptor Interaction with Estrogen Receptors. Analysis of Endocrine Disruptors with Estrogen Reporter Systems. Time Dependent Embryotoxicity of the Endogenous Luteolysin, Prostaglandin F2alpha, in Ruminants. Actions of Endocrine Disruptors on the Thyroid Axis. Endocrine Disruption of Hormone Storage and Transport. Metal Toxicity in Mammalian Reproduction. Structure-Activity Modeling of Endocrine Disruptors. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Biological Activity of Endocrine Disruptors in Aquatic Systems. Impact of Endocrine Disruptors on the Water Industry.