Characterization of Protein Therapeutics using Mass Spectrometry

Inbunden, Engelska, 2013

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Beskrivning

This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

Produktinformation

Utgivningsdatum:2013-05-06
Mått:155 x 235 x 28 mm
Vikt:748 g
Format:Inbunden
Språk:Engelska
Antal sidor:404
Upplaga:2012
Förlag:Springer-Verlag New York Inc.
ISBN:9781441978615

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Analytisk kemi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Mer om författaren

Dr. Guodong Chen has extensive pharmaceutical research experience in major pharmaceutical companies, including Eli Lilly, Schering-Plough (now Merck) and Bristol-Myers Squibb. He is currently heading a mass spectrometry group at Bristol-Myers Squibb's Princeton site, providing mass spectrometric/analytical support to drug discovery and development programs in small molecule pharmaceuticals and biologics. He has over 45 research publications in peer-reviewed journals and 9 book chapters covering the broad area of mass spectrometry and analytical sciences. He has co-edited two books: "Characterization of Impurities and Degradants Using Mass Spectrometry" and "Mass Spectrometry of Proteins/Peptides in Drug Discovery" (respectively 2010 and forthcoming). He is a short course instructor for two short courses on "LC/MS: Theory, Instruments and Applications" and "Practical Solutions to Characterization of Protein Therapeutics Using Mass Spectrometry" at Eastern Analytical Symposium.

Innehållsförteckning

Characterization of Protein Therapeutics by Mass Spectrometry: Recent Developments and Future Directions.- The Use of Mass Spectrometry to Characterize the Metabolism of Peptide Therapeutics.- Quantitative Analysis of Biologics Using Mass Spectrometry.- Maximizing Structural Information from Whole Protein Tandem Mass Spectrometry.- Disulfide Linkages of an Albumin Fusion Protein.- Detailed Structural Characterization of Monoclonal Antibodies.- Application of Protein Mass Spectrometry in Impurity and Degradant Characterization.- Mass Spectrometry Methods to Analyze Higher Order Structure of Protein Therapeutics by Chemical Footprinting.- Aglycosylations Alters Protein Conformation in Antibodies Engineered with Specific Effector Functions Using HDX-MS.- Characterizing Biotherapeutic Protein 3D Structures by Electrospray Ion-Mobility Mass Spectrometry.- Oxford University, Characterization of Assemblies of Proteins by Mass Spectrometry.