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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Naturvetenskap:allmänt
    4. Naturvetenskapens filosofi
    • Nyhet

    Perspectives on the Human Genome Project and Genomics Volume 24

    AvChristopher R. Donohue,Alan C. Love

    Häftad, Engelska, 2026

    Del i serien Minnesota Studies in the Philosophy of Science

    431 kr

    Beställningsvara. Skickas inom 5-8 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Interdisciplinary voices reflect on some of the most complex and consequential scientific undertakings of our timePerspectives on the Human Genome Project and Genomics is a groundbreaking volume that examines the pivotal roles of the National Institutes of Health (NIH) and the National Human Genome Research Institute (NHGRI) in the Human Genome Project (HGP) and the development of other major genomics projects. Drawing on newly uncovered archival materials and oral histories from NHGRI, this volume offers a multifaceted narrative of transformative scientific achievements of the twentieth and twenty-first centuries.Coeditors Christopher R. Donohue and Alan C. Love bring together a range of perspectives on the HGP's progress and legacy, as well as other major genomics projects, to explore not only their scientific achievements but also their social and political dimensions. Presenting reflections from historians, philosophers, and sociologists alongside those of key NHGRI scientists like Eric Green, Mark Guyer, and Elise Feingold; experts like Nature editor-in-chief Magdalena Skipper and geneticist Eric Vilain; and scholars of the ethical, legal, and social implications of genomics like Jean McEwan and Joy Boyer, Perspectives on the Human Genome Project and Genomics highlights the international, interdisciplinary collaborations and collective long view that underpinned these genomics initiatives aimed at a better understanding of our basic biology and genetic diseases.From genomic variation and sequencing technologies to the integration of big data and the influence of ancestry and gender, this book is an essential resource for deepening the discussion of the scientific, historical, and ethical impacts of genomics and a fascinating collection of insights into coordinated science in the making.Contributors: Rina Bliss, Joy Boyer, Lisa D. Brooks, Michel Dubois, Elise A. Feingold, Adam Felsenfeld, Miguel García-Sancho, Eric D. Green, Catherine Guaspare, Chris Gunter, Stephan Guttinger, Mark Guyer, Elke Jordan, Jonathan E. LoTempio Jr., Jean McEwen, Jane Peterson, Anya Plutynski, Ramya M. Rajagopalan, Emanuele Ratti, Sahotra Sarkar, Jeffery A. Schloss, Magdalena Skipper, Alexandra Soulier, Thomas Stoeger, Eric Vilain, Kris A. Wetterstrand.Retail e-book files for this title are screen-reader friendly with images accompanied by short alt text and/or extended descriptions.

    Produktinformation

    • Utgivningsdatum:2026-07-21
    • Mått:152 x 229 x 32 mm
    • Vikt:907 g
    • Format:Häftad
    • Språk:Engelska
    • Serie:Minnesota Studies in the Philosophy of Science
    • Antal sidor:600
    • Förlag:University of Minnesota Press
    • ISBN:9781517921026

    Utforska kategorier

    • Naturvetenskapens filosofi inom Naturvetenskap och teknik
    • Naturvetenskap:allmänt inom Naturvetenskap och teknik
    • Naturvetenskapens historia inom Naturvetenskap och teknik

    Mer om författaren

    Christopher R. Donohue was the historian of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health (NIH). He is currently a researcher at the Institute for Clinical and Translational Science (ICTS) and a member of the LoTempio Lab, both at University of California, Irvine. He is coeditor, with Charles Wolfe, of Vitalism and Its Legacy in Twentieth Century Life Sciences and Philosophy.Alan C. Love is Distinguished McKnight University Professor of Philosophy and Winton Chair in the Liberal Arts at the University of Minnesota, as well as director of the Minnesota Center for Philosophy of Science. He is coeditor of Beyond the Meme: Development and Structure in Cultural Evolution (Minnesota, 2019).

    Innehållsförteckning

    • ContentsPrefaceEric D. GreenList of AbbreviationsIntroduction: Complexity, Contingency, and Controversy in GenomicsChristopher R. Donohue and Alan C. LovePart I. Producing the Genome1. Challenges in the Early Years of the Human Genome Project at the National Institutes of Health: A Personal RetrospectiveElke Jordan2. Unsung Contributors to the Human Genome Project: NIH Staff and AdvisorsMark Guyer, Kris A. Wetterstrand, and Jane Peterson3. The NHGRI Genome Sequencing Cost Curve: An Indicator of Scientific ProgressKris A. Wetterstrand and Jonathan E. LoTempio Jr.4. History of the Encyclopedia of DNA Elements (ENCODE) ProjectElise A. Feingold5. NHGRI Genetic Variation ProgramLisa D. Brooks6. Genome Technology Development Grants for the Human Genome Project and BeyondJeffrey A. SchlossPart II. Contextualizing the Genome7. The Nature of Genomic PublishingChris Gunter and Magdalena Skipper8. Europe and the Genome: An Overlooked Strategy for a Translational GenomicsMiguel García‐Sancho9. Technological Change Driving Scientific Questions: Genomic Sequencing as a Case StudyAdam Felsenfeld and Kris A. Wetterstrand10. Addressing Ethical, Legal, and Social Implications (ELSI): Navigating Ongoing Productive TensionsJoy Boyer and Jean McEwen11. "Variations on a Theme": A History of Errors and Polymorphisms in the Human Genome Project and BeyondChristopher R. Donohue12. Transforming the Genome into a Clinical Resource: DNA, Data, and Algorithms in MedicineRamya M. RajagopalanPart III. Interpreting the Genome13. The Difference Genomics Makes: Characterizing Human Differences After the Human Genome ProjectRina Bliss14. The Trouble with Being "Socially Responsible": Science, GWAS, and Sexual OrientationMichel Dubois, Catherine Guaspare, and Eric Vilain15. Epigenetics in Public Health: Comments on the "From Cells to Society" ApproachAlexandra Soulier16. When Eugenic Enhancement Meets the Myth of Genetic ReductionismSahotra Sarkar17. modENCODE and the Elaboration of Functional Genomic MethodologyStephan Guttinger and Alan C. Love18. The Cancer Genome Atlas Project: Data-Driven, Hypothesis-Driven, or Something In-Between?Anya Plutynski19. Large-Scale Biology: Philosophical, Historical, and Computational PerspectivesEmanuele Ratti and Thomas StoegerContributorsIndex