Myosins

A Superfamily of Molecular Motors

AvLynne M. Coluccio

Inbunden, Engelska, 2020

Del 1239 i serien Advances in Experimental Medicine and Biology

2 219 kr

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Beskrivning

Myosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact.Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.

Produktinformation

Utgivningsdatum:2020-05-26
Mått:178 x 254 x 29 mm
Vikt:1 176 g
Format:Inbunden
Språk:Engelska
Serie:Advances in Experimental Medicine and Biology
Antal sidor:455
Upplaga:2
Förlag:Springer Nature Switzerland AG
ISBN:9783030380618

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Mer om författaren

Lynne Coluccio, PhD, began her career at Boston University as a Principal Scientist at the Boston Biomedical Research Institute (BBRI) in 1996. After the institute was closed in 2013, she became a Research Associate in the Department of Physiology & Biophysics at the Boston University School of Medicine and has remained since then. While at the BBRI, she played a variety of roles on the committee including as a chair of the Faculty Search Committee and as a member of the Public Relations Committee. Throughout her she career she has mentored dozens of students who have gone into academia, medicine, teaching, and music.

Innehållsförteckning

Introduction.- Myosin Structure.- Cargo Binding by Unconventional Myosins.- Cryo-EM of Actin-Myosin Structures.- Small Molecule Effectors of Myosin Function.- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction.- High-Speed Atomic Force Microscopy to Study Myosin Motility.- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches.- How Actin Tracks Affect Myosin Motors.- Myosins in the Nucleus.- Myosins in Cytokinesis.- Myosins and Disease.- Myosins and Hearing.- The Actomyosin Systems in Apicomplexa.- Approaches to Identify and Characterise MYO6-Cargo Interactions.- Class IX Myosins: Motorized RhoGAP Signaling Molecules.- Myosin X.- Myosin XVI.- Myosin XVIII.- Myosin XIX