Ferroptosis: Mechanism and Diseases

Dr. Andrés F. Flórez is currently a Postdoctoral Fellow in the Department of Molecular and Cellular Biology (MCB) at Harvard University. His research is focused in understanding the oncogene-based mechanisms regulating ferroptosis and to use this knowledge for designing new therapeutic strategies. He is also interested in the role of ferroptosis in controlling bacterial cell populations.Dr. Hamed Alborzinia is a Postdoctoral Fellow in the Division of Stem Cells and Cancer at the German Cancer Research Center (DKFZ). He also belongs to the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Heidelberg, Germany. His main research focus is to understand the metabolic properties of cancer cells in connection to novel forms of cell death, including ferroptosis.

• Foreword.- Ferroptosis: Concepts and Definitions.- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors.- Iron Homeostasis and Metabolism: Two Sides of a Coin.- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis.- Emerging Role for Ferroptosis in Infectious Diseases.- Small Molecule Regulators of Ferroptosis.- Necroptosis, The other main Caspase-Independent Cell Death.