Gene Regulation and Epigenetics

How Science Works

Häftad, Engelska, 2024

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Beskrivning

Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA.

Produktinformation

Utgivningsdatum:2024-10-05
Mått:155 x 235 x 15 mm
Vikt:480 g
Format:Häftad
Språk:Engelska
Antal sidor:258
Förlag:Springer International Publishing AG
ISBN:9783031687297

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Mer om författaren

Carsten Carlberg graduated in 1989 with a Ph.D. in biochemistry at the Free University Berlin (Germany). After positions as a postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland) and docent at the University of Düsseldorf (Germany), he is since 2000 a full professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). Since 2022, Prof. Carlberg is an ERA chair for nutrigenomics at the Polish Academy of Science. His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present, Prof. Carlberg’s projects focus on epigenome-wide effects of vitamin D on the human immune system in the context of cancer.

Innehållsförteckning

1. The human genome and its variations.- 2. Gene expression and chromatin.- 3. The basal transcriptional machinery.- 4. Transcription factors and signal transduction.- 5. A key transcription factor family: nuclear receptors.- 6. Genome-wide principles of gene regulation.- 7. DNA methylation.- 8. Histone modifications.- 9. Chromatin remodeling and organization.- 9. Regulatory impact of ncRNA.- 11. Epigenetics in development.- 12. Epigenetics and aging.- 13. Epigenetics and immunity.- 14. Epigenetics and disease.- 15. Cancer epigenetics.- 16. Nutritional epigenetics.