Carsten Carlberg – författare

The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences.

Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.

This textbook aims to describe in a condensed form the essentials of molecular immunology behind bacterial infections, the microbiome, viral infections (such as influenza and COVID-19), organ transplantations, autoimmunity, allergy and tumor immunology.

“Molecular Immunology: How Science Works” (ISBN 978-3-031-04024-5), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4).

In den ersten fünf Kapiteln werden die molekularen Grundlagen der Epigenetik erläutert, während die folgenden sieben Kapitel Beispiele für die Auswirkungen der Epigenetik auf die menschliche Gesundheit und Krankheit liefern.

Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process.

Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA.

Now in its second edition, this concise textbook provides an overview of the field of nutrigenomics, a topic at the intersection of nutrition and genetics that explores how dietary molecules interact with our genome and epigenome to influence health and disease.

Cancer remains one of the most complex challenges in modern medicine, demanding a solid understanding of its biological foundations. This textbook offers a clear and structured approach to cancer development, progression, and therapeutic response, effectively bridging molecular mechanisms with clinical practice. Readers gain in-depth insight into oncogenes and tumor suppressors, multistep tumorigenesis, the tumor microenvironment, metastasis, cancer immunology, and the rapidly expanding field of targeted and precision therapies.Designed with a strong didactic concept, the book features informative boxed sections highlighting key concepts, numerous high-quality illustrations, and a comprehensive glossary of technical terms. Its scaffolded structure guides learners from fundamental principles to advanced applications, making it particularly well suited for students.Based on Prof. Carsten Carlberg’s long-standing lecture course “Cancer Biology,” taught for many years at the University of Eastern Finland, and enriched by Dr. Eunike Velleuer’s clinical expertise, the book combines academic rigor with clinical relevance.The completely revised and expanded second edition includes new content on DNA methylation–based tumor classification, liquid biopsies, cancer epigenomics, aging as a cancer risk factor, sex differences, and cancer survivorship.Cancer Biology: How Science Works is an essential resource for students, practitioners, and anyone seeking a clear and scientifically grounded understanding of cancer and its clinical implications.

Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively.

Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively.

Warum verstoffwechseln wir dieselben Mahlzeiten so unterschiedlich? Haben ernährungsbedingte Erkrankungen eine genetische Ursache? Können Genuntersuchungen Vorhersagen zum Eintreten solcher Erkrankungen liefern? Welchen Einfluss haben Umwelt und Verhalten? Mit diesen und ähnlichen Fragen befasst sich das Gebiet der Nutrigenomik, das die Wechselwirkung zwischen Ernährung und Genom erforscht. Zu Beginn dieses Lehrbuchs wird ein Überblick über die Bedeutung der Nutrigenomik im Kontext der Ernährungswissenschaften gegeben. Sodann wird auf das menschliche Genom sowie seine Variationen eingegangen und der besondere Einfluss der Ernährung auf dessen Evolution beschrieben. Im Anschluss werden die molekularen Grundlagen der Wechselwirkung von Nährstoffen und anderen Nahrungsbestandteilen mit zellulären Signalnetzwerken besprochen, die die Genexpression modulieren. In drei abschließenden Kapiteln werden nutrigenomische Aspekte von Erkrankungen wie Adipositas, Diabetes und Herz-Kreislauf-Erkrankungen besprochen. Dieses Lehrbuch richtet sich an Studierende der Ernährungswissenschaften, der Biochemie und Molekularbiologie sowie der Biologie. Zahlreiche Farbabbildungen unterstützen die Wissensvermittlung, indem komplexe Abläufe grafisch zusammengefasst werden. Verbunden mit einem Glossar, das die wichtigsten Fachbegriffe erklärt, eignet sich das Werk somit ideal zur Modulbegleitung und Prüfungsvorbereitung.

Tauchen Sie ein in die Welt der Epigenetik, die Ihnen erklärt, wie Sie Ihre Gesundheit fördern und das Beste aus sich selbst herausholen können. Zunächst führt Sie das Werk in die molekularen Grundlagen ein, wie jede einzelne Zelle funktioniert und Information über ihre Umgebung verarbeitet.

Wer möchte nicht gesund bleiben und elegant altern? Dieses Buch bietet keine klassischen Ratschläge, sondern vermittelt ein tiefes Verständnis der Prozesse in unserem Körper, insbesondere des Immunsystems. Erfahren Sie, wie ein gut funktionierendes Immunsystem uns vor Infektionen und Krebs schützt, warum Überreaktionen zu Allergien und Autoimmunerkrankungen führen können und wie unser Lebensstil die Immunantwort beeinflusst.Dieses Buch richtet sich an Laien mit biologischen Grundkenntnissen, die mehr über die faszinierenden Mechanismen unseres Immunsystems erfahren möchten. Es ist ideal für alle, die Verantwortung für ihre Gesundheit übernehmen und die wissenschaftlichen Grundlagen für ein gesundes und langes Leben verstehen wollen.Mit klaren Erklärungen und wissenschaftlich fundierten Informationen zeigt dieses Buch, wie Sie Ihr Immunsystem stärken und somit Ihre Gesundheit und Lebensqualität verbessern können. Ein unverzichtbarer Leitfaden!

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin).