Ferdinand Molnár – författare

The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences.

“Molecular Immunology: How Science Works” (ISBN 978-3-031-04024-5), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4).

In den ersten fünf Kapiteln werden die molekularen Grundlagen der Epigenetik erläutert, während die folgenden sieben Kapitel Beispiele für die Auswirkungen der Epigenetik auf die menschliche Gesundheit und Krankheit liefern.

Now in its second edition, this concise textbook provides an overview of the field of nutrigenomics, a topic at the intersection of nutrition and genetics that explores how dietary molecules interact with our genome and epigenome to influence health and disease.

Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively.

Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively.

Warum verstoffwechseln wir dieselben Mahlzeiten so unterschiedlich? Haben ernährungsbedingte Erkrankungen eine genetische Ursache? Können Genuntersuchungen Vorhersagen zum Eintreten solcher Erkrankungen liefern? Welchen Einfluss haben Umwelt und Verhalten? Mit diesen und ähnlichen Fragen befasst sich das Gebiet der Nutrigenomik, das die Wechselwirkung zwischen Ernährung und Genom erforscht. Zu Beginn dieses Lehrbuchs wird ein Überblick über die Bedeutung der Nutrigenomik im Kontext der Ernährungswissenschaften gegeben. Sodann wird auf das menschliche Genom sowie seine Variationen eingegangen und der besondere Einfluss der Ernährung auf dessen Evolution beschrieben. Im Anschluss werden die molekularen Grundlagen der Wechselwirkung von Nährstoffen und anderen Nahrungsbestandteilen mit zellulären Signalnetzwerken besprochen, die die Genexpression modulieren. In drei abschließenden Kapiteln werden nutrigenomische Aspekte von Erkrankungen wie Adipositas, Diabetes und Herz-Kreislauf-Erkrankungen besprochen. Dieses Lehrbuch richtet sich an Studierende der Ernährungswissenschaften, der Biochemie und Molekularbiologie sowie der Biologie. Zahlreiche Farbabbildungen unterstützen die Wissensvermittlung, indem komplexe Abläufe grafisch zusammengefasst werden. Verbunden mit einem Glossar, das die wichtigsten Fachbegriffe erklärt, eignet sich das Werk somit ideal zur Modulbegleitung und Prüfungsvorbereitung.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin).