Pathobiology of Alzheimer's Disease

Advances in Genetics, Molecular and Cellular Biology

Inbunden, Engelska, 2026

3 471 kr

Kommande

Beskrivning

This new edition provides comprehensive and authoritative coverage of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of Alzheimer's disease. The chapters explore the physiology of polypeptides involved in early-onset and late-onset gene variants, degradation and clearance, and the role of tau. An emerging and exciting theme in the field is the seeding and spreading of toxic, misfolded protein species in the CNS; selected chapters review the nature of these toxic species and the underlying molecular and cellular mechanisms that drive disease pathogenesis. Additional chapters examine the development of organoids to test mechanisms, role of BDNF and neurogenesis in Alzheimer’s models, roles of peripheral immune cells, and the microbiome on modulation of Alzheimer's-like pathologies and neuroinflammation. The book also covers what are perhaps the most compelling new findings over the past decade: the identification of genetic variants in genes involved in innate immunity that predispose individuals to late-onset Alzheimer’s disease. Also, the new edition covers the data from animal models and humans that have led to the emergence of key biomarkers and clinical trials for Alzheimer’s disease that have real promise for changing the course of disease.

Produktinformation

Utgivningsdatum:2026-07-26
Mått:155 x 235 x undefined mm
Format:Inbunden
Språk:Engelska
Antal sidor:473
Upplaga:2
Förlag:Springer Nature Switzerland AG
ISBN:9783032268310

Utforska kategorier

Farmakologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Alzheimer, demens inom Medicin

Mer om författaren

Sangam S. Sisodia, PhD, is the Thomas A. Reynolds Sr. Family Professor of Neurobiology and Professor of Neurology at the University of Chicago. His research focuses on examining the cellular and molecular biology of molecules that are mutated in pedigrees with autosomal dominant, familial forms of Alzheimer's disease, and include the development of animal models that have been informative to examine Abeta amyloidosis, neurogenesis, exercise and enrichment, and the gut microbiome Rudolph Tanzi, PhD, is the Joseph and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Massachusetts General Hospital. He serves as Director of the Genetics and Aging Research Unit at MGH, which focuses on the molecular genetics of Alzheimer's disease.

Innehållsförteckning

The Role of Peripheral Immunity in Alzheimer’s Disease.- Genetics of Alzheimer’s Disease.- Apolipoprotein E: Normal Function and Roles in Neurodegenerative Disease.- Microglial Biology in Alzheimer’s Disease: From homeostatic functions to maladaptive activation and to therapeutic targeting.- Roles for adult neurogenesis in Alzheimer’s Disease.- TREM2: Sustaining Microglial Function and Promoting Neuroprotection in Alzheimer's Disease.- Synucleinopathies and Spreading.- Physiological Roles of the Amyloid Beta Protein.- The Role of the Innate Immune Receptor CD33 in Alzheimer’s Disease.- The Prion-Like Molecular Ontogeny of Alzheimer’s Disease.- The lymphatic-glymphatic system in Alzheimer’s disease.- The contributions of astrocytes to Alzheimer’s disease.- Immunotherapy of Alzheimer’s Disease.- Microglia and Inflammatory Immune Responses in Alzheimer's Disease.- Mechanisms of Tau Spreading.- MOLECULAR AND CELLULAR FUNCTIONS OF BACE.- Sex-Specific Gut Microbiota in the Pathophysiology of Alzheimer’s Disease.- Proteolytic Aβ Degradation: Enzymatic Pathways, Regulatory Mechanisms, and Therapeutic Implications.- Lessons learned from β-secretase inhibitor clinical trials.- Recapitulating Alzheimer’s Disease Pathology in Human Neural Cell Culture Models: Challenges and Opportunities.- Regulation γ-Secretase in Alzheimer’s Diease.- Biomarkers.- Diverse functions of lysosomes in brain health and Alzheimer’s disease.