This book presents a comprehensive overview of cellulose-based multilayer materials as a sustainable alternative for food packaging. It addresses the urgent need to reduce plastic pollution and food waste by substituting conventional packaging with sustainable alternatives.Based on scientific literature and recent advances, the book puts into perspective the close relationship between material design and food preservation. Emphasis is placed on the way that packaging must be tailored to meet the needs of different food products. Tailor-made packaging require prediction models, that allow to select a specific structure that will achieve the target properties. Thus, current models will be depicted in the book. The challenges of achieving targeted barrier properties, recyclability, and biodegradability are also covered.