Modified Nucleic Acids in Biology and Medicine

AvStefan Jurga,Volker A. Erdmann (Deceased)

Häftad, Engelska, 2018

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Beskrivning

Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases.

Produktinformation

Utgivningsdatum:2018-06-07
Mått:155 x 235 x 26 mm
Vikt:703 g
Format:Häftad
Språk:Engelska
Serie:RNA Technologies
Antal sidor:453
Förlag:Springer International Publishing AG
ISBN:9783319816937

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Biokemisk teknik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Innehållsförteckning

Transfer RNA Modifications: from Biological Functions to Biomedical Applications.- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications.- Sulfur-Modifications in tRNA: Function and Implications for Human Disease.- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium.- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health.- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation.- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification.- Methods for Determination of 2’-O-Me in RNA.- DiadenosineTetraphosphate (Ap4A), in Health and Disease.- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer.- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases.- Effect of Depurination on Cellular and Viral RNA.- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA.- Modifications in Therapeutic Oligonucleotides Improving the Delivery.- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications.- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies.- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy.- Polymerase Reactions that Involve Modified Nucleotides.