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Beskrivning
Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged.
1 The Mechanism of Action of Anti-Inflammatory Drugs.- 2 Human Group-V Phospholipase-A2 Expression in Pichia pastoris and Its Role in Eicosanoid Generation.- 3 Fatty-Acid Substrate Interactions with Cyclooxygenases.- 4 Structure, Function and Inhibition of Cyclooxygenases.- 5 Leukotriene-A4 Hydrolase: Probing the Active Sites and Catalytic Mechanisms by Site-Directed Mutagenesis.- 6 The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Cyclooxygenase and Fever in Knockout Mice.- 7 Leukotriene-B4 Receptor and Signal Transduction.- 8 Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-Inflammation: a Window for Therapeutic Opportunity.- 9 Lipoxin-Stable Analogs: Potential Therapeutic Downregulators of Intestinal Inflammation.- 10 The Role of Eicosanoids in Tumor Growth and Metastasis.- Previous Volumes Published in this Series.
