From the reviews: "This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. ... This is definitely an 'all-in' book for those interested in or working on TGFss receptor signal transduction in general and Smad proteins in particular. ... it is a must for all of us working in the field of TGFss signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007)

• Molecular Evolution of Smad Proteins.- C. Elegans TGF-? Signaling Pathways.- Smads In Drosophila – Interpretation Of Graded Signals In Vivo.- Delineating the TGF-?/Smad-Induced Cytostatic Response.- Smads In Mesenchymal Differentiation.- Smad Proteins in Apoptotic and Survival Signaling.- TGF-?/SMAD Signaling in Epithelial to Mesenchymal Transition.- Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer.- Trafficking of Serine/Threonine Kinase Receptors and Smad Activation.- Nucleocytoplasmic Shuttling of Smad Proteins.- Structural Insights into Smad Function and Specificity.- Regulation of Smad Function by Phosphorylation.- Regulation of Smad Functions Through Ubiquitination and Sumoylation Pathways.- Smad Transcriptional Co-Activators and Co-Repressors.- Integration of Signaling Pathways Via Smad Proteins.- Interplays Between The Smad and Map Kinase Signaling Pathways.- Gene Expression Signatures of TGF-?/Smad-Induced Responses.- Systems Biology Approaches to TGF-?/Smad Signaling.- Inhibitory Smads: Mechanisms of Action and Roles in Human Diseases.- Alterations in Smad Signaling in Carcinogenesis.- TGF-? Receptor Kinase Inhibitors for the Treatment of Cancer.- TGF-? Receptor Kinase Inhibitors for Treatment of Fibrosis.

From the reviews: "This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. ... This is definitely an 'all-in' book for those interested in or working on TGFss receptor signal transduction in general and Smad proteins in particular. ... it is a must for all of us working in the field of TGFss signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007)

• Molecular Evolution of Smad Proteins.- C. Elegans TGF-? Signaling Pathways.- Smads In Drosophila – Interpretation Of Graded Signals In Vivo.- Delineating the TGF-?/Smad-Induced Cytostatic Response.- Smads In Mesenchymal Differentiation.- Smad Proteins in Apoptotic and Survival Signaling.- TGF-?/SMAD Signaling in Epithelial to Mesenchymal Transition.- Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer.- Trafficking of Serine/Threonine Kinase Receptors and Smad Activation.- Nucleocytoplasmic Shuttling of Smad Proteins.- Structural Insights into Smad Function and Specificity.- Regulation of Smad Function by Phosphorylation.- Regulation of Smad Functions Through Ubiquitination and Sumoylation Pathways.- Smad Transcriptional Co-Activators and Co-Repressors.- Integration of Signaling Pathways Via Smad Proteins.- Interplays Between The Smad and Map Kinase Signaling Pathways.- Gene Expression Signatures of TGF-?/Smad-Induced Responses.- Systems Biology Approaches to TGF-?/Smad Signaling.- Inhibitory Smads: Mechanisms of Action and Roles in Human Diseases.- Alterations in Smad Signaling in Carcinogenesis.- TGF-? Receptor Kinase Inhibitors for the Treatment of Cancer.- TGF-? Receptor Kinase Inhibitors for Treatment of Fibrosis.