Tau Biology

Häftad, Engelska, 2021

Del 1184 i serien Advances in Experimental Medicine and Biology

2 540 kr

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Beskrivning

In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau.

Produktinformation

Utgivningsdatum:2021-08-26
Mått:178 x 254 x 22 mm
Vikt:897 g
Format:Häftad
Språk:Engelska
Serie:Advances in Experimental Medicine and Biology
Antal sidor:416
Förlag:Springer Verlag, Singapore
ISBN:9789813293601

Utforska kategorier

Fysiologi inom Medicin
Biokemi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Mer om författaren

Akihiko TakashimaGakushuin University, Dept Life Sci., Lab Alzheimers Dis., JapanBenjamin WolozinBoston University, School of Med., Dept Pharmacol., USALuc BueeUniversity of Lille, CHU Lille, INSERM, Memory & Resources Res. Ctr., France

Innehållsförteckning

1) Structure and role of Tau molecule.- (1) Tau structure in solution: FRET study.- (2) Tau structure in solution: NMR study.- (3) Structure of NFT: Biochemical approach.- (4) Structure of NFT: CryoEM approach.- (5) MAPT tau gene and FTDP-17 mutation.- (6) Tau phosphorylation.- (7) Tau acetylation.- (8) Tau truncation.- (9) Tau interacted proteins: interactome.- (10) Tau clearance mechanism.- 2) Tau localization and function.- (11) Localization of Tau.- (12) Axonal transport.- (13) Synaptic localization of tau.- (14) Role of tau in synapse.- (15) Tau in nucleus and nucleic acids.- (16) Tau and the translational stress response.- 3) Tauopathies; pathology, drivers, and marker.- (17) Tau pathology with aging.- (18) Clinical symptom and pathology of FTD including FTDP-17.- (19) Chronic Traumatic Encephalopathy.- (20) Myotonic dystrophies.- (21) Tau PET.- (22) Tau PET/connectome/fMRI.- (23) Stress.- (24) Diabetes.- (25) Relationship between ApoE and tau.- (26) Relationship between Ab and tau.- 4) Tau aggregation, and therapy.- (27) Tau Oligomer.- (28) Tau droplet formation.- (29) Stress granule.- (30) Tau secretion.- (31) Tau seeding.- (32) Prion-like Tau propagation.- (33) Experimental models for tauopathies.- (34) Dementia therapy targeting tau.- (35) Tau aggregation inhibitor.