Kazunori Sango, MD, PhD, Associate Director & Project LeaderDiabetic Neuropathy Project, Department of Sensory and Motor SystemsTokyo Metropolitan Institute of Medical Science, Tokyo, JapanJunji Yamauchi, PhD, Associate Professor & Group LeaderDepartment of Pharmacology, National Research Institute for Child Health and Development, Tokyo, JapanToru Ogata, MD, PhD, DirectorDepartment of Rehabilitation for the Movement Functions, National Rehabilitation Center for Persons with Disabilities, Center for Sport Science and Health Promotion, Tokorozawa, JapanKeiichiro Susuki, MD, PhD, Assistant ProfessorDepartment of Neuroscience, Cell Biology, and PhysiologyBoonshoft School of Medicine, Wright State University, Dayton, Ohio, USA

• Part 1. Myelination in neural development and regeneration.- 1. Cellular signal-regulated Schwann cell myelination and remyelination.- 2.Regulatory mechanism of peripheral nerve myelination by glutamate-induced signaling.- 3.Cytoskeletal signal-regulated oligodendrocyte myelination and remyelination.- 4.Activity-dependent myelination.- 5.Heterogeneity of oligodendrocytes and their precursor cells.- Part 2. Specialized structures along the myelinated nerve fibers.- 6.Functional domains in myelinated axons.- 7.Physiology of myelinated nerve conduction and pathophysiology of demyelination.- 8.Under the ECM dome: the physiological role of the perinodal extracellular matrix as an ion diffusion barrier.- 9.Oligodendrocyte physiology modulating axonal excitability and nerve conduction.- 10.Mitochondrial dynamics in physiology and pathology of myelinated axons.- 11.The role of sulfatides in axon-glia interactions.- 12.Structures and molecular composition of Schmidt-Lanterman incisures.- Part 3. Myelin pathology in the central nervous system.- 13.Pelizaeus-Merzbacher disease: molecular and cellular pathologies and associated phenotypes.- 14.Multiple sclerosis.- 15.Visualization of myelin for the diagnosis and treatment monitoring of multiple sclerosis.- 16.Roads to formation of normal myelin structure and pathological myelin structure.- 17.Therapeutic strategies for oligodendrocyte-mediated remyelination.- 18.Brain tumors of glial cell origin.- Part 4. Myelin pathology in the peripheral nervous system.- 19.Schwann cell and the pathogenesis of Charcot-Marie-Tooth disease.- 20.Guillain- Barré Syndrome.- 21.Chronic inflammatory demyelinating polyneuropathy.- 22.Schwann cells as crucial players in diabetic neuropathy.- 23.Drug-induced demyelinating neuropathies.- 24.Transthyretin amyloid neuropathy: the Schwann cell hypothesis.

Kazunori Sango, MD, PhD, Associate Director & Project LeaderDiabetic Neuropathy Project, Department of Sensory and Motor SystemsTokyo Metropolitan Institute of Medical Science, Tokyo, JapanJunji Yamauchi, PhD, Associate Professor & Group LeaderDepartment of Pharmacology, National Research Institute for Child Health and Development, Tokyo, JapanToru Ogata, MD, PhD, DirectorDepartment of Rehabilitation for the Movement Functions, National Rehabilitation Center for Persons with Disabilities, Center for Sport Science and Health Promotion, Tokorozawa, JapanKeiichiro Susuki, MD, PhD, Assistant ProfessorDepartment of Neuroscience, Cell Biology, and PhysiologyBoonshoft School of Medicine, Wright State University, Dayton, Ohio, USA

• Part 1. Myelination in neural development and regeneration.- 1. Cellular signal-regulated Schwann cell myelination and remyelination.- 2.Regulatory mechanism of peripheral nerve myelination by glutamate-induced signaling.- 3.Cytoskeletal signal-regulated oligodendrocyte myelination and remyelination.- 4.Activity-dependent myelination.- 5.Heterogeneity of oligodendrocytes and their precursor cells.- Part 2. Specialized structures along the myelinated nerve fibers.- 6.Functional domains in myelinated axons.- 7.Physiology of myelinated nerve conduction and pathophysiology of demyelination.- 8.Under the ECM dome: the physiological role of the perinodal extracellular matrix as an ion diffusion barrier.- 9.Oligodendrocyte physiology modulating axonal excitability and nerve conduction.- 10.Mitochondrial dynamics in physiology and pathology of myelinated axons.- 11.The role of sulfatides in axon-glia interactions.- 12.Structures and molecular composition of Schmidt-Lanterman incisures.- Part 3. Myelin pathology in the central nervous system.- 13.Pelizaeus-Merzbacher disease: molecular and cellular pathologies and associated phenotypes.- 14.Multiple sclerosis.- 15.Visualization of myelin for the diagnosis and treatment monitoring of multiple sclerosis.- 16.Roads to formation of normal myelin structure and pathological myelin structure.- 17.Therapeutic strategies for oligodendrocyte-mediated remyelination.- 18.Brain tumors of glial cell origin.- Part 4. Myelin pathology in the peripheral nervous system.- 19.Schwann cell and the pathogenesis of Charcot-Marie-Tooth disease.- 20.Guillain- Barré Syndrome.- 21.Chronic inflammatory demyelinating polyneuropathy.- 22.Schwann cells as crucial players in diabetic neuropathy.- 23.Drug-induced demyelinating neuropathies.- 24.Transthyretin amyloid neuropathy: the Schwann cell hypothesis.