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In the next millennium, it is anticipated that human factors issues will take centre stage in initiatives targeted at enhancing economic competitiveness and productivity. This development is already discernible in nascent knowledge and digital based industries and economies, which are expected to emerge in force in the near future and continue to dominate thereafter. These developments will establish irreversibly the emerging global economy. The theme of the APCHI 2000 conference is: "Towards a seamless integration of collaborative human computer systems" to reflect the already discernible shift in focus of human computer interaction (HCI). whilst the theme of the ASEAN Ergonomics 2000 conference is: "From user centeredness to people centeredness" to reflect the imminent shift in focus that is required of human factors.

The papers in these proceedings provide a good contrast of human factors contributions to both old and new economies that make up ASEAN and APEC. They highlight the diverse roles human factors can play in advancing the quality of life in developed, developing and third world nations. They also serve as a guide to human factors practitioners in old economies on what to expect as their economies develop.

The editors invited selected authors who had participated in or observed developments in biochemistry and molecular biology, particularly in the second half of this century, to record their personal recollections of the times and circumstances in which they worked. Having been given free reign, both content and style of the contruibutions reflect the flavour of the personality of the author.

The book reflects the explosive development of biochemistry and molecular biology and related sciences that had led to the almost unique situation of these fields coming of age at a time when their founding fathers, or their scientific children, were alive and well.

The contributions in this volume encompass a wide variety of experiences in many different countries and in very different fields of biochemistry.

This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

The International Committee on Large Dams (ICOLD) held its 26th International Congress in Vienna, Austria (1-7 July 2018). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

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This all-new edition of How To Do Everything: iCloud fully covers iCloud’s versatile features and offers step-by-step directions on how to use each one, including Shared Photo Streams, the iWork for iCloud apps, and iCloud Keychain. You’ll learn how to set up iCloud, transfer and sync app-specific data, documents, files, photos, music, and other content among your computers and iOS mobile devices.

Use iCloud with your Mac, iPhone, iPad, iPad mini, and iPod touch Migrate from Apple MobileMe to iCloudLearn new iCloud features, including Shared Photo Streams, iWork for iCloud online apps, iCloud Keychain, and much moreManage your digital music library and iTunes purchases with iCloudUse the Premium iTunes Match serviceStore and manage your digital photos with My Photo StreamShare your digital images with others using iCloud’s Shared Photo StreamsSync files and documents among computers and iOS devices Manage and sync your Safari bookmarks, reading list, and passwords using iCloud and iCloud KeychainWork with iWork for iCloudLearn about other cloud-based servicesSync and share apps, app-related data, and eBooks among iOS mobile devices and your computer(s) Back up your iPhone and iPad with iCloudStream Apple TV content to your HD TVLocate a Lost Mac, iPhone, iPad or iPod touch with iCloud’s Find My… featureManage your iCloud email accountTroubleshoot iCloud-related problems

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

In this volume, members of the International Translational Research Network on Orofacial Neurological Disorders and invited experts provide authoritative overviews of new aspects of motor function and sensation relating to neurological disorders in orofacial regions. Orofacial movements constitute fundamental motor patterns with essential roles in consummatory behavior, self-care, defensive and attack behaviors, vocalization and, in higher mammals, verbal as well as non-verbal communication. Clinically, dysfunction in orofacial movement is evident in numerous dental, cranio-maxillo-facial and neuropsychiatric disorders, including dysphagia, Huntington's disease, Parkinson's disease and schizophrenia.

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases.

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction.

Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual's lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease.

This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age.

This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances.

Integrates current research on the actions of addictive substances in neurological disease Includes functional foods, such as caffeine beverages, that have habituating effects on the brain Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances

The record of man's early evolution, though still fragmentary, is more complete on the African continent than anywhere else in the world. The ecological context of this evolution, however, has been studied intensively only in recent years. This pioneering volume draws together eminent specialists from many fields--physical anthropologists, zoologists, geologists, paleontologists, and prehistorians--who summarize here the results of their diverse research on Pleistocene environments and the cultural and biological evolution of man in Africa.This volume was sponsored by the Wenner-Gren Foundation for Anthropological Research Inc., which met at Burg Wartenstein, Austria. The editors have field experience in Africa, especially eastern and equatorial Africa. This experience is coupled with their awareness of the need to integrate results of numerous field studies bearing on the biological-behavioral evolution of higher primates with other field studies on the paleoecology and the mammalian ecology of sub-Saharan Africa.The book includes contributions on Pleistocene stratigraphy and climatic changes throughout the African continent; on the origin and evolution of the earliest man-like creatures in Africa; on the dating, distribution, and adaptation of Pleistocene hunter-gatherer peoples; and on the ecology, biology, and social behavior of African primate and human populations. The chapters reflect vividly the state of current knowledge at the time and indicate paths for future research. Over 100 maps and figures, detailed bibliographies, and a comprehensive index contribute to the importance of the volume for basic reference use.

Diagnostic Molecular Biology, Second Edition provides an up-to-date comprehensive overview of the latest advances in molecular diagnostics and the fundamental molecular aspects in this area. The book delves into the essential principles behind the transmission and expression of genetic information, including nucleic acids, proteins, and chromosomes, specifically their genome structure, life cycle, and evolution. The latest methods and instrumentation in the field are examined with detailed procedures and explanations provided for each technique. A range of techniques are also investigated, such as those used in sequencing analysis, genome and transcriptome analysis, and nucleic acid amplitification techniques. This book covers the collection, isolation, and purification of DNA, RNA, and protein from different sources. Additionally, discussion on the applications of next-generation sequencing (NGS) and the role of NGS in the future of precision medicine is included. The book also examines the use of molecular diagnostics for chromosomal disorders, inherited diseases, and infectious diseases. Moreover, this new edition features recent advances in the detection of respiratory virus infections in humans, including that of SARS-CoV2. Diagnostic Molecular Biology, Second Edition, is an ideal reference for researchers, lab technicians, and students in medical laboratory science, molecular biology, microbiology, virology, and related fields.

Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

The adaptation of desirable agricultural plants to infertile and problem soils is an increasingly important strategy for improving food supplies in many parts of the world. The plant breeding approach complements, and in some cases may replace agronomic practices such as the use of fertilizers and soil amendments to provide solutions which are economically and environmentally sustainable. The Symposium at which the papers in this volume were presented drew together workers in plant breeding, plant nutrition, physiology, biochemistry and molecular biology to discuss research on gene systems which affect the mineral nutrition of plants. Papers describe successes in plant breeding for problem soils as well as advances in understanding of mechanisms at the whole plant and cellular levels. Papers in the "molecular" area point the way to the contribution which the new biology will make to this field in the future. The reviews and research papers are grouped under five topics: better plants for acid soils; salinity tolerance; efficiency of uptake and use of macronutrients; efficiency for iron and micronutrients; and tolerance of heavy metals and boron.

Excavation, Support and Monitoring is the fourth volume of the five-volume set Rock Mechanics and Engineering and contains twenty-three chapters from key experts in the following fields- Excavation Methods;- Support Technology;- Monitoring Technology;- Integrated Engineering Monitoring and Analysis.The five-volume set “Comprehensive Rock Engineering”, which was published in 1993, has had an important influence on the development of rock mechanics and rock engineering. Significant and extensive advances and achievements in these fields over the last 20 years now justify the publishing of a comparable, new compilation. Rock Mechanics and Engineering represents a highly prestigious, multi-volume work edited by Professor Xia-Ting Feng, with the editorial advice of Professor John A. Hudson. This new compilation offers an extremely wide-ranging and comprehensive overview of the state-of-the-art in rock mechanics and rock engineering and is composed of peer-reviewed, dedicated contributions by all the key experts worldwide.Key features of this set are that it provides a systematic, global summary of new developments in rock mechanics and rock engineering practices as well as looking ahead to future developments in the fields. Contributors are world-renowned experts in the fields of rock mechanics and rock engineering, though younger, talented researchers have also been included. The individual volumes cover an extremely wide array of topics grouped under five overarching themes: Principles (Vol. 1), Laboratory and Field Testing (Vol. 2), Analysis, Modelling and Design (Vol. 3), Excavation, Support and Monitoring (Vol. 4) and Surface and Underground Projects (Vol. 5). This multi-volume work sets a new standard for rock mechanics and engineering compendia and will be the go-to resource for all engineering professionals and academics involved in rock mechanics and engineering for years to come.

Nanoelectronic Device Applications Handbook gives a comprehensive snapshot of the state of the art in nanodevices for nanoelectronics applications. Combining breadth and depth, the book includes 68 chapters on topics that range from nano-scaled complementary metal–oxide–semiconductor (CMOS) devices through recent developments in nano capacitors and AlGaAs/GaAs devices. The contributors are world-renowned experts from academia and industry from around the globe.The handbook explores current research into potentially disruptive technologies for a post-CMOS world. These include:Nanoscale advances in current MOSFET/CMOS technologyNano capacitors for applications such as electronics packaging and humidity sensorsSingle electron transistors and other electron tunneling devicesQuantum cellular automata and nanomagnetic logicMemristors as switching devices and for memoryGraphene preparation, properties, and devicesCarbon nanotubes (CNTs), both single CNT and random networkOther CNT applications such as terahertz, sensors, interconnects, and capacitorsNano system architectures for reliabilityNanowire device fabrication and applicationsNanowire transistorsNanodevices for spintronicsThe book closes with a call for a new generation of simulation tools to handle nanoscale mechanisms in realistic nanodevice geometries. This timely handbook offers a wealth of insights into the application of nanoelectronics. It is an invaluable reference and source of ideas for anyone working in the rapidly expanding field of nanoelectronics.

This volume, originally published in 1975, grew out of Resources for the Future’s involvement as a consultant to the Marine Ecosystem Analysis programme management within the National Oceanic and Atmospheric Agency. Here, researchers look at the state of the art in aquatic ecological modelling in a resource management context. Although the aim of the research in this volume is specific, the models used can be applied in broader contexts and provide conceptual frameworks for regional residuals-environmental quality management and other ecological modelling. This title is suitable for students interested in Environmental Studies.

This volume, originally published in 1975, grew out of Resources for the Future’s involvement as a consultant to the Marine Ecosystem Analysis programme management within the National Oceanic and Atmospheric Agency. Here, researchers look at the state of the art in aquatic ecological modelling in a resource management context. Although the aim of the research in this volume is specific, the models used can be applied in broader contexts and provide conceptual frameworks for regional residuals-environmental quality management and other ecological modelling. This title is suitable for students interested in Environmental Studies.

The Handbook of Software for Engineers and Scientists is a single-volume, ready reference for the practicing engineer and scientist in industry, government, and academia as well as the novice computer user. It provides the most up-to-date information in a variety of areas such as common platforms and operating systems, applications programs, networking, and many other problem-solving tools necessary to effectively use computers on a daily basis.Specific platforms and environments thoroughly discussed include MS-DOS®, Microsoft® Windows™, the Macintosh® and its various systems, UNIX™, DEC VAX™, IBM® mainframes, OS/2®, Windows™ NT, and NeXTSTEP™. Word processing, desktop publishing, spreadsheets, databases, integrated packages, computer presentation systems, groupware, and a number of useful utilities are also covered. Several extensive sections in the book are devoted to mathematical and statistical software. Information is provided on circuits and control simulation programs, finite element tools, and solid modeling tools. Additional coverage is included on data communications and networking.Many appendices at the end of the book provide useful supplemental information, such as ASCII codes, RS-232 parallel port and pinout information, and ANSI escape sequences.This valuable resource handbook brings together a wide variety of topics and offers a wealth of information at the reader's fingertips.

This collection features five peer-reviewed reviews on optimising photosynthesis in crops.The first chapter reviews current understanding of the biochemistry, regulation and limitation of the C3 photosynthesis cycle in crops. It provides detailed discussions on CO2 assimilation in C3 photosynthesis, as well as the carboxylation, reduction and regeneration phases of the C3 cycle.The second chapter considers the recent emergence of using phenotyping techniques to analyse crop functionality and photosynthesis. It reviews the relationship between photosynthesis, crop growth and stress response and explores phenotyping photosynthesis in varying environments.The third chapter discusses the process of modifying mesophyll conductance to optimise photosynthesis in crops. The chapter considers recent research efforts to manipulate the structure and composition of cells walls, membranes and liquid phases to achieve this.The fourth chapter explores improving photosynthesis in rice and details the need to optimise photosynthetic efficiency as a means of boosting yield ceilings in rice production.The final chapter reviews some of the key factors determining photosynthetic performance and explores the options for improving the photosynthetic capacity and efficiency of wheat by selecting for a range of important traits.

Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.