Akhileshwar Kumar Srivastava – författare

Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural productsderived from invertebrates that can be used as part of cancer treatment.

Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients.This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedicalfield interested in understanding more about natural products with anticancer potential.

Discusses the application of natural products in place of conventional drugs to minimize the side effects in cancer treatment Explains the relation between evolutionary mechanisms and climate change for production of secondary metabolites

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development.

Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.

Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans

Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery systems in cancer treatment. Several nanotechnological methods are presented to enhance drug solubility, sustainability, bioavailability, and gastrointestinal permeability of these phytochemicals. Current understanding of the relevant information presented on therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers who want to work in the areas of drug development targeting phytochemicals for cancer therapy.

Explains the significance of phytochemicals in cancer therapy, along with their pharmacologic actionElucidates the importance of various phytochemicals in cancer therapyExplains the emerging need of drug-delivery system for plant metabolitesDeciphers the various drug-delivery systems for phytomedicines involved in cancer treatmentsDescribes the crucial role of nanotechnology in the development of drug-delivery systems for anticancer phytochemicalsExplores the challenges associated with developing drug-delivery systems for phytochemicals to cure cancer

Plant-Based Drug Discovery: Unveiling Molecular Targets for Metabolic Conditions provides an in-depth examination of the molecular mechanisms of phytochemicals and their potential in treating metabolic diseases. This comprehensive guide begins with an introduction to the prevalence and impact of metabolic disorders, emphasizing the significant role of phytochemicals in their management. The book delves into scientific concepts and research findings, offering valuable insights for researchers and healthcare professionals in the fields of molecular biology, biochemistry, pharmacology, and biotechnology. Chapters cover various crucial topics such as oxidative stress, epigenetic mechanisms, and mitophagy.In addition, they explore the targeting of molecular chaperones and the molecular targets of plant nutraceuticals for treating obesity, cardiovascular disease, and type 2 diabetes. The book also addresses technological advances, including AI and nanotechnology, highlighting opportunities and challenges in improving the use of plant molecules for metabolic disorder treatments. It serves as an essential resource for those engaged in drug discovery and related areas.Considers the therapeutic application of phytochemicals for the treatment of metabolic diseases, including cardiovascular disease, obesity, and type 2 diabetesExplores phytochemicals at the molecular level, covering signaling pathways of oxidative stress, mitophagy, inflammasomes, molecular chaperones, receptors, and how these mechanisms can be used to treat diseasesDiscusses the use of artificial intelligence and high-throughput omics technologies in plant-based drug discovery

Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.Explores the impact of exosomes across a range of diseases, considering their potential for regenerative medicine, targeted drug delivery, and personalized therapeuticsFeatures techniques for isolation, characterization, and functional assessment of EVs, including ultracentrifugation, size exclusion chromatography, electron microscopy, nanoparticle tracking analysis, and functional assaysAddresses the engineering of EVs and exosomes and the integration of AI, machine learning, and nanotechnologyIncludes future prospects for the field, alongside predicted breakthroughs, challenges, and ethical considerations

Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios. As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.Explores fundamental principles and methodologies in plant metabolite analysisOffers practical insights into the application of plant metabolite profiling technologies, with case studies illustrating real-world examples of plant metabolomics utilization for pharmaceuticals, cosmetics, nutraceuticals, and other industriesServes as an interdisciplinary resource for researchers and practitioners across a variety of areasExamines regulatory considerations relevant to the development and commercialization of plant-based therapeutics and productsHighlights the potential of metabolic engineering strategies to address global challenges in agriculture, healthcare, and sustainable bioproduction

This book explains the translational aspects of ethnomedicinal plants of different geographical regions including India by explaining the medicinal properties against several diseases, genomic evolution in changing environments, metabolic profiling for biomarker discovery, the role of non-coding RNA in the synthesis of secondary metabolites, genome-wide transcriptome profiling, application of pluripotent stem cells for drug discovery, the importance of high-throughput omics, and genome-editing techniques. In addition, some of the chapters have been designed to describe the role of artificial intelligence, plant database, and network-based drug discovery to explore the medicinal importance of compounds as well as challenges and opportunities in drug discovery from ethnomedicinal plants. The book serves as a great source of information for the students, researchers/scientists of diverse fields such as pharmacognosy, plant physiologists, biotechnologists, and pharmaceutical scientists etc., working in the areas of phytotherapy from ethnomedicinal plants.

This contributed volume brings out a comprehensive collection of changes from cellular to molecular levels in medicinal plants under extreme environments. The focus of this book is to address the molecular changes in medicinal plants under different abiotic stresses. Medicinal plants are regarded as rich resources of components that can be used for drug development in the pharmaceutical industry. A few medicinal plants are considered vital sources of nutrients and solicited for their therapeutic properties. Therefore, it is essential to understand medicinal plants' interaction under abiotic stresses as compounds obtained from these plants play an important role in human health. This book is of interest to students, teachers, researchers, scientists, medicinal plant experts, and policymakers. Also, the book provides study material for undergraduate and graduate students of botany, environmental sciences, medicinal and aromatic plants, biochemistry, and biotechnology. National and international scientists working in the area of medicinal plants, drug development, and policymakers will also find this a useful read