Athel Cornish-Bowden – författare

Mathematics is essential to the study and understanding of biochemistry yet most undergraduates do not have a grasp of maths. This book sets out all the mathematics needed for an undergraduate course in biochemistry, assuming a minimum of prior knowledge. Emphasis is placed on topics necessary for biochemists and all the examples are relevant to biochemistry. Each chapter contains illustrative boxes and worked examples and also a problem section (the answers are given in the back of the book). The book starts by covering the basic concepts of mathematics such as manipulating fractions, functions, and plotting graphs and then explains exponents and logarithms in depth. The next two chapters cover all the ordinary differentiation and integration required by the biochemist. Partial differentiation is explained in a later chapter. Chapter 6 is about solving equations (linear, simultaneous, quadratic, and higher-order) and the final chapter covers the basic ideas of statistics. Basic Mathematics for Biochemists will therefore be invaluable to all biochemistry undergraduates and will also be useful to more experienced biochemists needing to refresh their maths.

THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over the landmark discoveries of the 1950s and 1960s relating to inhibition of enzymes at branch-points by the end products of metabolic pathways, and the interpretation of allosteric effects and cooperativity. Even those who have become convinced that the classical ideas provide only the starting point for understanding metabolic control have been by no means unanimous in their assess­ ment of the direction in which one should advance. In this book we have tried to include all of the current points of view, including the view that the classical theories tell us all that we need to know. We have not seen it as our role as editors to paper over the cracks that exist and to pretend that we can speak to the world with one voice.

Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex­ pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta­ bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio­ technologists can only ignore these topics at their peril.

The study of multienzyme systems has advanced considerably during the 1990s. The cell is more complicated than classical biochemistry presents it; it contains more structure, and the behaviour of any system of enzymes is more elaborate than can be explained in simple terms. Nevertheless, classical enzymology and metabolism remain central to any modification of the metabolic behaviour of organisms, as attempted by modern biotechnology and drug development techniques. In this work the authors draw attention to the drawbacks, problems, and opportunities associated with this field. The areas covered include problems with current practice, the imposition of human objectives on organisms, understanding health and disease, computer modelling, the increasingly complex picture of cell structure, control and regulation of metabolism, and the general contribution metabolic control is making to biochemistry on a broader canvas.

Research now shows us that long-term activation of the stress cycle can have a hazardous, even lethal, effect on the body, increasing the risk of obesity, heart disease, depression, cancer, and other illnesses. This new edition of an award-winning book presents cutting-edge research on the effects of stress.Edited by one of the world’s authorities in stress management, occupational psychology, and occupational medicine, Handbook of Stress Medicine and Health, Second Edition offers a completely revised and updated look at the different types of stress, including their characteristics, symptoms, duration, and treatment approaches. The text proposes a generic theory on stress and health and explores the relationship of stress to a variety of health outcomes, including heart disease, cancer, mental health, burnout, and complications of the endocrine and immune systems. It addresses the link between stress and personality, and discusses the impact of social support on various health conditions. The final chapters deal with stress and its consequences, such as the emotional processing of traumatic events, dealing with stress in families and in chronic disease, and coping with stress in the workplace. With contributions from the foremost leaders in the field, this authoritative book evaluates a wide range of psychosocial factors that contribute to many of today’s major illnesses. It also proposes strategies for prevention and management, which will hopefully encourage future research into the reduction of stress.

THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over the landmark discoveries of the 1950s and 1960s relating to inhibition of enzymes at branch-points by the end products of metabolic pathways, and the interpretation of allosteric effects and cooperativity. Even those who have become convinced that the classical ideas provide only the starting point for understanding metabolic control have been by no means unanimous in their assess­ ment of the direction in which one should advance. In this book we have tried to include all of the current points of view, including the view that the classical theories tell us all that we need to know. We have not seen it as our role as editors to paper over the cracks that exist and to pretend that we can speak to the world with one voice.

Now in its fourth edition, this textbook is one of the few titles worldwide to cover enzyme kinetics in its entire scope and the only one to include its implications for bioinformatics and systems biology. Multi-enzyme complexes and cooperativity are therefore treated in more detail than in any other textbook on the market. The respected and well known author is one of the most experienced researchers into the topic and writes with outstanding style and didactic clarity. As with the previous editions, he presents here steady-state kinetics and fast reactions, supplementing each chapter with problems and solutions. For the first time, this edition features a companion website providing all figures in colour www.wiley-vch.de/home/fundenzykinet