Biplab Debnath – författare

This book provides a comprehensive review of the emerging role of extrachromosomal DNA (ecDNA) in cancer, highlighting its significance in tumor progression, oncogene amplification, drug resistance, and clinical applications. Extrachromosomal DNA in Cancer: Mechanisms, Biomarkers, and Therapeutic Implications explores the structural and functional characteristics of ecDNA, emphasizing its role in shaping the genetic and epigenetic landscapes of cancer cells. The book discusses the impact of ecDNA on tumor heterogeneity, metastasis, and immune evasion, providing insights into how ecDNA contributes to cancer evolution and therapeutic resistance. The text also examines cutting-edge imaging techniques, computational approaches, and non-invasive diagnostic applications of ecDNA, highlighting its potential as a biomarker in precision oncology. Additionally, it presents the novel therapeutic strategies targeting ecDNA, addressing challenges and opportunities in integrating these insights into cancer treatment.FeaturesExplores the structural formation and oncogenic role of ecDNA in tumor development and progressionDiscusses the influence of ecDNA on gene expression, epigenetics, and immune modulation in cancerExamines the role of ecDNA in drug resistance, metastasis, and disease recurrenceHighlights advanced imaging, computational tools, and non-invasive diagnostic applications of ecDNAReviews emerging therapeutic strategies targeting ecDNA for improved cancer treatment and personalized medicine This book is intended for researchers and students of cancer biology, molecular biology, and biotechnology.

This book provides a comprehensive understanding of the transformative potential of stem cell therapies for improving skin health and treating debilitating dermatological disorders. Stem Cell Therapy in Dermatological Disorders delves into the emerging field of stem cell therapy as a revolutionary approach to treating various dermatological conditions. This book provides a comprehensive overview of the science behind stem cell technology, focusing on its applications in skin regeneration, wound healing, and the management of chronic skin diseases. It examines the cellular and molecular mechanisms that make stem cells uniquely suited for dermatological use, exploring their ability to promote tissue repair, modulate inflammation, and restore the skin’s structural integrity. This book aims to bridge the gap between experimental research and clinical application, presenting up-to-date findings on the different types of stem cells used in dermatology, including mesenchymal stem cells, induced pluripotent stem cells, and embryonic stem cells. It highlights the role of stem cells in addressing disorders such as atopic dermatitis, psoriasis, vitiligo, and chronic non-healing wounds. Readers will find in-depth discussions on current therapeutic techniques, the challenges of translating preclinical studies to human trials, and the ethical considerations associated with stem cell therapies. In addition to discussing the state-of-the-art in stem cell-based treatments, the book also casts an eye on the future, identifying gaps in existing knowledge and potential areas for innovation. The authors provide insights into novel delivery systems, genetic engineering advancements, and combinatory approaches that may enhance the efficacy and safety of stem cell therapies in dermatology. This volume serves as an essential resource for dermatologists, researchers, and clinicians seeking to understand the transformative potential of stem cell therapies in improving skin health and treating debilitating dermatological disorders. Readers will find the book: Explores the latest breakthroughs in stem cell therapy for skin disorders;Bridges the gap between basic science and clinical applications;Discusses mesenchymal stem cells (MSCs), iPSCs, and exosome-based therapies.Audience Dermatologists, dermatopathologists, plastic surgeons, medical aestheticians, researchers, clinicians, and biotechnology and pharmaceutical professionals involved in regenerative medicine and aesthetic dermatology.

Cancer cells survive and thrive by radically reshaping the way they use energy, nutrients, and metabolic pathways. This book offers a clear and comprehensive exploration of this rapidly evolving field, revealing how tumors rewire core biochemical processes to sustain proliferation, evade cell death, and adapt to the pressures of the tumor microenvironment. From foundational concepts to cutting‑edge discoveries, the book provides an essential entry point for understanding the metabolic logic that underlies cancer progression. Central to this volume is an in‑depth examination of glutamine metabolism. Alongside this focus, the book extends broadly across the metabolic landscape, covering glycolysis, lipid synthesis and utilization, redox regulation, mitochondrial dynamics, and metabolic communication between cancer cells and their surrounding stromal and immune partners. Each chapter distills mechanistic insight while emphasizing translational relevance, bridging basic science with the latest therapeutic strategies and clinical applications. Written by leading researchers and clinicians, this book serves as a valuable resource for scientists, oncologists, and drug developers seeking to understand and target the metabolic vulnerabilities of cancer. Whether exploring metabolic reprogramming in cancer stem cells, evaluating biomarkers of metabolic states, or assessing emerging therapies and clinical trial data, readers will gain an integrated perspective on how metabolism shapes tumor behavior and influences treatment outcomes. This is an indispensable guide for anyone committed to advancing cancer research, improving patient care, and translating metabolic insights into meaningful therapeutic advances.