Board on Chemical Sciences and Technology – författare

People spend the vast majority of their time inside their homes and other indoor environments where they are exposed to a wide range of chemicals from building materials, furnishings, occupants, cooking, consumer products, and other sources. Despite research to date, very little is known about how exposures to indoor chemicals across complex chemical phases and pathways affect human health. The COVID-19 pandemic has only increased public awareness of indoor environments and shed light on the many outstanding questions about how best to manage chemicals indoors. This report identifies gaps in current research and understanding of indoor chemistry and new approaches that can be applied to measure, manage, and limit chemical exposures. Why Indoor Chemistry Matters calls for further research about the chemical transformations that can occur indoors, pathways and timing of indoor chemical exposure, and the cumulative and long-term impacts of exposure on human health. Research priorities should consider factors that contribute to measurable environmental health disparities that affect vulnerable populations, such as the age, location, and condition of buildings that can alter exposures to indoor chemicals.

In 2002, the U.S. Food and Drug Administration (FDA) launched the Pharmaceutical Quality for the 21st Century Initiative to encourage adoption of innovative technologies that would lead to an agile, flexible pharmaceutical manufacturing sector. The goal was to encourage a transition to manufacturing processes and approaches that could produce high-quality drugs reliably without extensive regulatory oversight. Much progress has been made toward that goal as the industry has developed and advanced new technologies, but more progress is required as recent natural disasters and the coronavirus pandemic have revealed vulnerabilities in supply chains and highlighted the need to modernize pharmaceutical manufacturing further.

At the request of the FDA Center for Drug Evaluation and Research (CDER), Innovations in Pharmaceutical Manufacturing on the Horizon identifies emerging technologies - such as product technologies, manufacturing processes, control and testing strategies, and platform technologies - that have the potential to advance pharmaceutical quality and modernize pharmaceutical manufacturing for products regulated by CDER. This report describes many innovations to modernize the manufacture of drug substances and drug products, to advance new control approaches, and to develop integrated, flexible, and distributed manufacturing networks within 5-10 years.

At the request of the National Science Foundation and the U.S. Departmentof Energy, the National Research Council conducted an in-depth benchmarking analysis to gauge the current standing of the U.S. chemistry field in the world. The Future of U.S. Chemistry Research: Benchmarks and Challenges highlights the main findings of the benchmarking exercise.

This in-depth benchmarking analysis is based on measures including numbers of published papers, citations, trends in degrees conferred, patent productivity, and awards. The book concludes that the United States is presently, and is expected to remain, among the world''s leaders in all subareas of chemical engineering research. However, U.S. leadership in some classical and emerging subareas will be strongly challenged.

This critical analysis will be of interest to practicing chemical engineers, professors and students in the discipline, economists, policy makers, major research university administrators, and executives in industries dependent upon innovations in chemistry.

Protecting buildings and their occupants from biological and chemical attacks to ensure continuous building operations is seen as an urgent need in the Department of Defense, given recent technological advances and the changing threats. Toward this end, the Department of Defense established the Immune Building Program to develop protective systems to deter biological and chemical attacks on military facilities and minimize the impacts of attacks should they occur. At the request of the Defense Threat Reduction Agency, the National Research Council convened a committee to provide guiding principles for protecting buildings from airborne biological or chemical threat agents and outline the variables and options to consider in designing building protection systems. This report addresses such components of building protection as building design and planning strategies; heating, ventilating, and air-conditioning systems; filtration; threat detection and identification technologies; and operational responses. It recommends that building protection systems be designed to accommodate changing building conditions, new technologies, and emerging threats. Although the report''s focus is on protection of military facilities, the guiding principles it offers are applicable to protection of public facilities as well.

Biological warfare agent (BWA) detectors are designed to provide alerts to military personnel of the presence of dangerous biological agents. Detecting such agents promptly makes it possible to minimize contamination and personnel exposure and initiate early treatment. It is also important, though, that detectors not raise an alarm when the situation does not warrant it.The question considered in this book is whether Agent-Containing Particles per Liter of Air (ACPLA) is an appropriate unit of measure for use in the evaluation of aerosol detectors and whether a better, alternative measure can be developed.The book finds that ACPLA alone cannot determine whether a health threat exists. In order to be useful and comparable across all biological agents and detection systems, measurements must ultimately be related to health hazard.A Framework for Assessing the Health Hazard Posed by Bioaerosols outlines the possibility of a more complex, but more useful measurement framework that makes it possible to evaluate relative hazard by including agent identity and activity, particle size, and infectious dose.

Mechanical engineering is critical to the design, manufacture, and operation of small and large mechanical systems throughout the U.S. economy. This book highlights the main findings of a benchmarking exercise to rate the standing of U.S. mechanical engineering basic research relative to other regions or countries. The book includes key factors that influence U.S. performance in mechanical engineering research, and near- and longer-term projections of research leadership.

U.S. leadership in mechanical engineering basic research overall will continue to be strong. Contributions of U.S. mechanical engineers to journal articles will increase, but so will the contributions from other growing economies such as China and India. At the same time, the supply of U.S. mechanical engineers is in jeopardy, because of declines in the number of U.S. citizens obtaining advanced degrees and uncertain prospects for continuing to attract foreign students. U.S. funding of mechanical engineering basic research and infrastructure will remain level, with strong leadership in emerging areas.

However, testing biological standoff detection systems is difficult because open-air field tests with BWAs are not permitted under international conventions and because the wide variety of environments in which detectors might be used may affect their performance. This book explores the question of how to determine whether or not a biological standoff detection system fulfills its mission reliably if we cannot conduct open-air field tests with live BWAs.

This book presents an in-depth analysis of the investment in catalysis basic research by the U.S. Department of Energy (DOE) Office of Basic Energy Sciences (BES) Catalysis Science Program. Catalysis is essential to our ability to control chemical reactions, including those involved in energy transformations. Catalysis is therefore integral to current and future energy solutions, such as the environmentally benign use of hydrocarbons and new energy sources (such as biomass and solar energy) and new efficient energy systems (such as fuel cells). Catalysis for Energy concludes that BES has done well with its investment in catalysis basic research. Its investment has led to a greater understanding of the fundamental catalytic processes that underlie energy applications, and it has contributed to meeting long-term national energy goals by focusing research on catalytic processes that reduce energy consumption or use alternative energy sources. In some areas the impact of the research has been dramatic, while in others, important advances in catalysis science are yet to be made.

A strong chemical workforce in the United States will be essential to the ability to address many issues of societal concern in the future, including demand for renewable energy, more advanced materials, and more sophisticated pharmaceuticals. High school chemistry teachers have a critical role to play in engaging and supporting the chemical workforce of the future, but they must be sufficiently knowledgeable and skilled to produce the levels of scientific literacy that students need to succeed.To identify key leverage points for improving high school chemistry education, the National Academies'' Chemical Sciences Roundtable held a public workshop, summarized in this volume, that brought together representatives from government, industry, academia, scientific societies, and foundations involved in outreach programs for high school chemistry teachers. Presentations at the workshop, which was held in August 2008, addressed the current status of high school chemistry education; provided examples of public and private outreach programs for high school chemistry teachers; and explored ways to evaluate the success of these outreach programs.

Laboratory facilities are complex, technically sophisticated, and mechanically intensive structures that are expensive to build and to maintain. Hundreds of decisions must be made before and during new construction or renovation that will determine how successfully the facility will function when completed and how successfully it can be maintained once put into service.

This book provides guidance on effective approaches for building laboratory facilities in the chemical and biochemical sciences. It contains both basic and laboratory-specific information addressed to the user community—the scientists and administrators who contract with design and construction experts. The book will also be important to the design and construction communities—the architects, laboratory designers, and engineers who will design the facility and the construction personnel who will build it—to help them communicate with the scientific community for whom they build laboratory facilities.

However, testing biological standoff detection systems is difficult because open-air field tests with BWAs are not permitted under international conventions and because the wide variety of environments in which detectors might be used may affect their performance. This book explores the question of how to determine whether or not a biological standoff detection system fulfills its mission reliably if we cannot conduct open-air field tests with live BWAs.

Prudent Practices in the Laboratory—the book that has served for decades as the standard for chemical laboratory safety practice—now features updates and new topics. This revised edition has an expanded chapter on chemical management and delves into new areas, such as nanotechnology, laboratory security, and emergency planning.

Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices in the Laboratory provides guidance on planning procedures for the handling, storage, and disposal of chemicals. The book offers prudent practices designed to promote safety and includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more.

Prudent Practices in the Laboratory will continue to serve as the leading source of chemical safety guidelines for people working with laboratory chemicals: research chemists, technicians, safety officers, educators, and students.

Following the attacks of September 11, 2001 and the anthrax letters, the ability to detect biological threats as quickly as possible became a top priority. In 2003 the Department of Homeland Security (DHS) introduced the BioWatch program—a federal monitoring system intended to speed detection of specific biological agents that could be released in aerosolized form during a biological attack. The present volume evaluates the costs and merits of both the current BioWatch program and the plans for a new generation of BioWatch devices. BioWatch and Public Health Surveillance also examines infectious disease surveillance through hospitals and public health agencies in the United States, and considers whether BioWatch and traditional infectious disease surveillance are redundant or complementary.

A strong chemical workforce in the United States will be essential to the ability to address many issues of societal concern in the future, including demand for renewable energy, more advanced materials, and more sophisticated pharmaceuticals. High school chemistry teachers have a critical role to play in engaging and supporting the chemical workforce of the future, but they must be sufficiently knowledgeable and skilled to produce the levels of scientific literacy that students need to succeed.To identify key leverage points for improving high school chemistry education, the National Academies'' Chemical Sciences Roundtable held a public workshop, summarized in this volume, that brought together representatives from government, industry, academia, scientific societies, and foundations involved in outreach programs for high school chemistry teachers. Presentations at the workshop, which was held in August 2008, addressed the current status of high school chemistry education; provided examples of public and private outreach programs for high school chemistry teachers; and explored ways to evaluate the success of these outreach programs.

Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior—concepts familiar to physicists and chemists—are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior.Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment.This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions—and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.

There is growing concern about the possible use of toxic industrial chemicals or other hazardous chemicals by those seeking to perpetrate acts of terrorism. The U.S. Chemical Security Engagement Program (CSP), funded by the U.S. Department of State and run by Sandia National Laboratories, seeks to develop and facilitate cooperative international activities that promote best practices in chemical security and safe management of toxic chemicals, including:

The Department of State called on the National Academies to assist in the CSP''s efforts to promote chemical safety and security in developing countries.

Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior—concepts familiar to physicists and chemists—are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior.Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment.This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions—and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.

There is growing concern about the possible use of toxic industrial chemicals or other hazardous chemicals by those seeking to perpetrate acts of terrorism. The U.S. Chemical Security Engagement Program (CSP), funded by the U.S. Department of State and run by Sandia National Laboratories, seeks to develop and facilitate cooperative international activities that promote best practices in chemical security and safe management of toxic chemicals, including:

The Department of State called on the National Academies to assist in the CSP''s efforts to promote chemical safety and security in developing countries.

Combustion has provided society with most of its energy needs for millenia, from igniting the fires of cave dwellers to propelling the rockets that traveled to the Moon. Even in the face of climate change and the increasing availability of alternative energy sources, fossil fuels will continue to be used for many decades. However, they will likely become more expensive, and pressure to minimize undesired combustion by-products (pollutants) will likely increase. The trends in the continued use of fossil fuels and likely use of alternative combustion fuels call for more rapid development of improved combustion systems. In January 2009, the Multi-Agency Coordinating Committee on Combustion Research (MACCCR) requested that the National Research Council (NRC) conduct a study of the structure and use of a cyberinfrastructure (CI) for combustion research. The charge to the authoring committee of Transforming Combustion Research through Cyberinfrastructure was to: identify opportunities to improve combustion research through computational infrastructure (CI) and the potential benefits to applications; identify necessary CI elements and evaluate the accessibility, sustainability, and economic models for various approaches; identify CI that is needed for education in combustion science and engineering; identify human, cultural, institutional, and policy challenges and how other fields are addressing them. Transforming Combustion Research through Cyberinfrastructure also estimates the resources needed to provide stable, long-term CI for research in combustion and recommends a plan for enhanced exploitation of CI for combustion research.